Effect of Cell-Penetrating Arginine Peptide on Interaction of Photosensitizer Chlorin e6 Incorporated into Phospholipid Nanoparticles with Tumor Cells

Kostryukova, L.V.; Korotkevich, Ekaterina; Morozevich, G. E.; Колесанова, Е. Ф.; Melnikova, M. V.; Filatova, Yu. V.; Torkhovskaya, T. I.; Prozorovskii, V. N.; Tikhonova, E G; Ipatova, O. M.

doi:10.1007/s10517-019-04524-x

Cited by 7 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And one of the PCNR uptake pathways is mostly macropinocytosis-dependent in A375 cells ( 167 ). Heptapeptide R7, a novel peptide, was synthesized to promote internalization of chlorin e6(a photosensitizer) into HepG2 cells by activation of endocytosis and/or macropinocytosis in comparison with initial NPs without peptide R7 ( 168 ). SN21, a peptide based on stromal-derived factor 1α, can induce macropinocytosis and deliver functional siRNA and proteins such as antibodies and Cre recombinases ( 128 ).…”

Section: Anticancer Therapies Targeting Macropinocytosis In Cancersmentioning

confidence: 99%

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

et al. 2021

View full text Add to dashboard Cite

Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells. On the one hand, cells expressing RAS genes (such as K-RAS, H-RAS) under the stress of nutrient deficiency can spontaneously produce constitutive macropinocytosis to promote the growth of cancer cells by internalization of extracellular nutrients (like proteins), receptors, and extracellular vesicles(EVs). On the other hand, abnormal expression of RAS genes and drug treatment (such as MOMIPP) can induce a novel cell death associated with hyperactivated macropinocytosis: methuosis. Based on the dual effect, there is immense potential for designing anticancer therapies that target macropinocytosis in cancer cells. In view of the fact that there has been little review of the dual effect of macropinocytosis in cancer cells, herein, we systematically review the general process of macropinocytosis, its specific manifestation in cancer cells, and its application in cancer treatment, including anticancer drug delivery and destruction of macropinocytosis. This review aims to serve as a reference for studying macropinocytosis in cancers and designing macropinocytosis-targeting anticancer drugs in the future.

show abstract

Section: Anticancer Therapies Targeting Macropinocytosis In Cancersmentioning

confidence: 99%

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In this study, Ce6 was encapsulated in phospholipid nanoparticles and then heptaarginine peptide was incorporated into the nanoparticles, which caused higher internalization of Ce6 in HepG2 cells, in comparison to nanoparticles alone. 80 P 160 is another peptide that selectively binds to breast cancer cells, and for that reason, it has been explored in active targeting. Kim et al developed an active targeting-based Ce6 nanoformulation using p 18-4, an analogue of p 160.…”

Section: Ce6mentioning

confidence: 99%

“…utilized heptaarginine peptide (linear chain of 7 arginine residues) for the active targeting-based Ce6 delivery. In this study, Ce6 was encapsulated in phospholipid nanoparticles and then heptaarginine peptide was incorporated into the nanoparticles, which caused higher internalization of Ce6 in HepG2 cells, in comparison to nanoparticles alone . P 160 is another peptide that selectively binds to breast cancer cells, and for that reason, it has been explored in active targeting.…”

Section: Ce6 Nanoformulations For Monotherapymentioning

confidence: 99%

Chlorin e6: A Promising Photosensitizer in Photo-Based Cancer Nanomedicine

Hak

Ali

Sankaranarayanan

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Conventional cancer treatment modalities are often associated with major therapeutic limitations and severe side effects. Photodynamic therapy is a localized noninvasive mode of treatment that has given a different direction to cancer research due to its effectivity against a wide range of cancers and minimal side effects. A photosensitizer is the key component of photodynamic therapy (PDT) that generates cytotoxic reactive oxygen species to eradicate cancer cells. As the therapeutic effectivity of PDT greatly depends upon the photosensitizer, great efforts have been made to search for an ideal photosensitizer. Chlorin e6 is a FDA approved second generation photosensitizer that meets the desired clinical properties for PDT. It is known for its high reactive oxygen species (ROS) generation ability and anticancer potency against many types of cancer. Hydrophobicity is a major drawback of Ce6 that leads to its poor biodistribution and rapid clearance from the circulatory system. To overcome this drawback, researchers have designed and fabricated several types of nanosystems, which can enhance Ce6 solubility and thereby enhance its bioavailability. These nanosystems also improve tumor accumulation of Ce6 by selectively targeting the cancer cells through passive and active targeting. In addition, Ce6 has been employed in many combination therapies like chemo-photodynamic therapy, photoimmunotherapy, and combined photodynamic–photothermal therapy. A combination therapy is more curative than a single therapy due to the synergistic effects of individual therapies. Ce6-based nanosystems for combination therapies have shown excellent results in various studies and provide a promising platform for cancer treatment.

show abstract

Therapeutic Potential of CPPs

Langel

2023

CPP, Cell-Penetrating Peptides

View full text Add to dashboard Cite

Effect of Cell-Penetrating Arginine Peptide on Interaction of Photosensitizer Chlorin e6 Incorporated into Phospholipid Nanoparticles with Tumor Cells

Cited by 7 publications

References 14 publications

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

Chlorin e6: A Promising Photosensitizer in Photo-Based Cancer Nanomedicine

Therapeutic Potential of CPPs

Contact Info

Product

Resources

About