Effect of Celecoxib Administration on the Skin of 40-Week-Old Mice

Abstract

Various side effects associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in analgesia have been reported. Among the NSAIDs, celecoxib has fewer side effects and is often used in therapeutic applications. However, the effect of celecoxib on aged skin is unknown. In this study, we investigated the effects of celecoxib administration on the skin of aged mice. We analyzed a 40-week-old mouse model and a 10-week-old mice as the control group. The animals were orally administered celecoxib for four consecutive days and then killed and dissected the day after the last dose. In aged mice treated with celecoxib, the water content of the stratum corneum, which is one of the markers of dry skin, was lower than that in the control and young mice groups. In addition, serum hyaluronic acid, creatinine, and inflammatory cytokines in the collected blood samples of aged mice were elevated compared to those in other mice groups, suggesting the onset of acute renal injury. Therefore, it was considered that acute renal injury occurred from the administration of celecoxib to aged mice, whereas dry skin developed by the promotion of inflammatory cytokine secretion and release into the bloodstream in this group.

Royal Jelly, A Super Food, Protects Against Celecoxib-Induced Renal Toxicity in Adult Male Albino Rats

“…26 However, it has the same potential for adverse renal effects as traditional NSAIDs, 27 even in therapeutic doses, 28 especially in clinical situations associated with a renal impairment, such as sodium depletion, hypovolemia, cirrhosis, congestive heart failure, nephrotic syndrome, chronic kidney disease (CKD), 23 and old age. 29 Although there have been 2 cases of celecoxib-induced nephrotoxicity after 10 months of continuous usage, it has largely been also reported with short-term use, as fast as within 2 weeks. 30 Therefore, the same precautions in patients at risk for adverse renal effects probably apply to both the nonselective NSAIDs and COX-2 selective inhibitors.…”