Effect of CD133 polymorphisms on the risk of developing liver cirrhosis and hepatocellular carcinoma induced by viral hepatitis

Hassan, Marwa; Nasr, Sami Mohamed; Elzallat, Mohamed

doi:10.1016/j.virusres.2022.198714

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…In addition, NAC1 enhances the immune evasion mechanism of HBV by suppressing CD8 + T cells, which play a crucial role in the cytotoxic immune response [ 16 ]. This study offers a novel mechanistic perspective to comprehend the development of HBV-associated liver cirrhosis and liver cancer [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development

Chen,

Guo,

et al. 2024

Oncogenesis

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Our study aimed to elucidate the molecular mechanisms underlying NAC1 (nucleus accumbens associated 1) transcriptional regulation of LDHA and its role in HBV immune evasion, thus contributing to the development of cirrhosis and hepatocellular carcinoma (HCC). Utilizing public datasets, we performed differential gene expression and weighted gene co-expression network analysis (WGCNA) on HBV-induced cirrhosis/HCC data. We identified candidate genes by intersecting differentially expressed genes with co-expression modules. We validated these genes using the TCGA database, conducting survival analysis to pinpoint key genes affecting HBV-HCC prognosis. We also employed the TIMER database for immune cell infiltration data and analyzed correlations with identified key genes to uncover potential immune escape pathways. In vitro, we investigated the impact of NAC1 and LDHA on immune cell apoptosis and HBV immune evasion. In vivo, we confirmed these findings using an HBV-induced cirrhosis model. Bioinformatics analysis revealed 676 genes influenced by HBV infection, with 475 genes showing differential expression in HBV-HCC. NAC1 emerged as a key gene, potentially mediating HBV immune escape through LDHA transcriptional regulation. Experimental data demonstrated that NAC1 transcriptionally activates LDHA, promoting immune cell apoptosis and HBV immune evasion. Animal studies confirmed these findings, linking NAC1-mediated LDHA activation to cirrhosis and HCC development. NAC1, highly expressed in HBV-infected liver cells, likely drives HBV immune escape by activating LDHA expression, inhibiting CD8 + T cells, and promoting cirrhosis and HCC development.

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Section: Discussionmentioning

confidence: 99%

NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development

Chen,

Guo,

et al. 2024

Oncogenesis

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“…Hepatocellular carcinoma (HCC) is a disease that is both pathologically and clinically heterogeneous. It is caused by the disruption of several intracellular and extracellular signaling pathways [ 5 , 6 ]. The initial stages of HCC development entail the disruption of a set of interdependent mechanisms that control the cell cycle, cell growth, and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-122 mimic/microRNA-221 inhibitor combination as a novel therapeutic tool against hepatocellular carcinoma

Hassan

Elzallat

Aboushousha

et al. 2023

Non-coding RNA Research

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Innovative model of surface-enhanced Raman spectroscopy for exosomes identification: An approach for the diagnosis of hepatocellular carcinoma

Elkady

Hassan

Hagag

et al. 2023

Clinica Chimica Acta

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Effect of CD133 polymorphisms on the risk of developing liver cirrhosis and hepatocellular carcinoma induced by viral hepatitis

Cited by 4 publications

References 25 publications

NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development

NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development

MicroRNA-122 mimic/microRNA-221 inhibitor combination as a novel therapeutic tool against hepatocellular carcinoma

Innovative model of surface-enhanced Raman spectroscopy for exosomes identification: An approach for the diagnosis of hepatocellular carcinoma

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