Abstract:CaS/DMSO has been the subject of work in our group because it dissociates spontaneously in proton rich environments to produce Ca2+ ions and H2S. Extracellular Ca2+ concentrations in the neighbourhood of 500nM can induce apoptosis. Smaller concentrations of H2S can also induce apoptosis. We present here our efforts to establish the effect of CaS clusters in the cytoskeleton and focal adhesion points of human skin adherent benign and melanoma cells. We hypothesize that if the CaS nanoclusters can induce program… Show more
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