Effect of Carum carvi and Curcuma longa on hormonal and reproductive parameter of female rats.

Thakur, Shilpa; Bawara, Bhavana; Dubey, Aditi; Nandini, Durgesh; Chauhan, Nagendra Singh; Saraf, D. K.

doi:10.5138/ijpm.2009.0975.0185.05791

Cited by 30 publications

(18 citation statements)

References 12 publications

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“…Artemisia herba-alba, on the other hand, causes a significant decrease in the relative ovarian weights and embryo weights in rats in addition to reductions in percentage pregnancies and in the number of implantation sites and viable fetus number Qazan et al 2007, Priya et al 2014. Carum carvi and Trigonella foenum-graecum L. (Fabaceae) exert their antifertility effect by significant reduction of Leutinzing Hormone (LH) and Follicle Stimulating Hormone (FSH), blockage of estrus phase with increase in weights of ovaries, uterus and body (Thakur et al 2009;Agrahari & Singh 2014;Priya et al 2014). Accordingly, pregnant women or those who would like to conceive should be discouraged from the consumption of these herbs.…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

“…Significant antifertility in female rats for significant reductions in LH and FSH, blockage of estrus phase with increase in weights of ovaries, uterus and body (Thakur et al 2009;Priya et al 2014;Agrahari & Singh 2014). Caraway is considered among herbs commonly associated with galactogogue properties, but strongly contraindicated in pregnancy and breastfeeding due to its antispasmodic effects (Mannion & Mansell 2012).…”

Section: Introductionmentioning

confidence: 99%

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The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

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“…One of the free radicals is the Reactive Oxygen Species (ROS) group [10]. ROS can cause lipid peroxidation, a chain reaction that will produce MDA, inhibition of the free radical activity of ROS group by curcumin will inhibit also lipid peroxidation process and cause decreasing MDA production [22].…”

Section: Resultsmentioning

confidence: 99%

Malondialdehyde (MDA) Ovary and Estradiol Blood Serum Levels of Premenopause White Rat (Rattus norvegicus) after Turmeric Powder (Curcuma longa L.) Treatment

Suprihatin

Widyarti

Rifa’i

et al. 2019

J.Trop.Life.Science

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Premenopause is a physiological condition in a female individual that has entered the aging period, a condition usually characterized by elevated MDA levels and decreased estrogen levels. The objective of this study was to determine the level of ovarian MDA and estradiol serum levels of premenopausal white rat blood after oral turmeric powder treatment. The animals used were 30 female Wistar strains white rat, age 12 months with an average body weight 200-250 g. The animals were divided into 6 groups, namely the negative control group (P0) with 4 ml/day distilled water treatment; positive control group (P1), this group was treated with pure curcumin powder 6.75 mg/kg BW; treatment group 1 (P2), group was treated with turmeric powder 100 mg/kg BW; treatment group 2 (P3); treatment group 3 (P4); and treatment group 4 (P5), these group were treated with turmeric powder at 200 mg/kg BW; 400 mg/kg BW; and 800 mg/kg BW dose respectively. Oral Treatment was administered daily for 27 days. Blood collection was performed on days 0, 14, and 28. The ovarian collection was conducted on day 28. MDA ovarian level was measured using TBA method and blood serum estradiol level was measured using ELISA method. The results exhibited that the positive control group (P1) and the treatment group (P2-P5) showed significantly lower ovarian MDA levels compared with the negative control group (P0). The turmeric powder dose 200 mg/kg BW (P3) can increase estradiol levels by day 14 (3.32 ± 0.26 ρg/mL) and at day 28 (4.01 ± 0.26 ρg/mL).

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“…Thakur et al [16] reported that both aqueous and ethanolic extracts of rhizome of Curcuma longa showed a significant antifertility activity in female albino rats. Also the amount of estrogen in ethanolic extract treated animals was found to have increased significantly.…”

Section: Resultsmentioning

confidence: 99%

Bio-Remedial Effect of Curcuma Longa on Estrogen and Sub-Cellular Structures of Ovaries of Pesticide Exposed Mice

2017

WJPR

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Pesticides are some of the most frequently released toxic chemicals into the environment. Although the use of pesticides enhances crop productivity, human beings also pay a price for the benefits.Chlorpyrifos (an organophosphate) is a broad-spectrum insecticide against a variety of insects and mites in agriculture and allied sectors.After absorption through the guts and lungs, it rapidly distributes to all organs exerting damaging effects at cellular and sub-cellular levels.The present work is designed to study the bio-remedial effect of Curcuma longa (Turmeric) on estrogen and sub-cellular structure of ovary of Chlorpyrifos exposed Swiss albino mice. Chlorpyrifos administration at 6 mg/kg b.w./day for 8 weeks was followed by 8 weeks administration of alcoholic rhizome extract (5% Ethanol) of Curcuma longa at 50 mg/kg b.w./day. Estrogen level was increased in Chlorpyrifos administered group while it gradually decreased in Curcuma longa administered group. Degeneration of nucleus, nuclear membrane, mitochondria, endoplasmic reticulum and Golgi complex was observed in Chlorpyrifos administered group, while Curcuma longa restored mitochondria, nuclear membrane, nucleus, endoplasmic reticulum and Golgi complex effectively. Thus it is evident from the study that Curcuma longa plays an effective role against Chlorpyrifos induced toxicity on estrogen. It also maintains histology of ovary effectively. It restores cellular and sub-cellular toxicity of Chlorpyrifos exposed ovary effectively and restores normal function of ovary in female.

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Effect of Carum carvi and Curcuma longa on hormonal and reproductive parameter of female rats.

Cited by 30 publications

References 12 publications

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Malondialdehyde (MDA) Ovary and Estradiol Blood Serum Levels of Premenopause White Rat (Rattus norvegicus) after Turmeric Powder (Curcuma longa L.) Treatment

Bio-Remedial Effect of Curcuma Longa on Estrogen and Sub-Cellular Structures of Ovaries of Pesticide Exposed Mice

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