Effect of cardiopulmonary bypass on gastrointestinal perfusion and function

Epidemiology of gastrointestinal bleeding in adult patients on extracorporeal life support

“…GI bleeding may be more frequent in ECLS patients as a result of multifactorial coagulopathy, generation of systemic inflammation, and nonpulsatile blood flow during VA ECLS, which can lead to reduced gastric perfusion and pH [2][3][4][5]. Future prospective studies would be helpful in confirming our findings.…”

Ogilvie syndrome: a rare but lethal intestinal complication of coronary revascularization

“…Besides, a pH decrease occurs during CABG, which is another possible reason for gastric complications such as ulcer formations and bleedings. A similar pH pattern is also observable for mucous intestinal tissue and intestinal villus (5). On the other hand, mesenteric ischemia is a catastrophic complication of CABG that can be caused by various conditions such as older age, intraaortic balloon pulsation implantations, perioperative hypotension, arrhythmia, metabolic acidosis, mesenteric atherosclerosis, thromboembolism during CPB and vasopressor medications (6).…”

Mechanical circulatory support with the ABIOMED BVS 5000: The Toronto General Hospital experience

“…It has been easier for nurses to manage and has required no added personnel for device management -unlike ECMO support, which requires an attending perfusionist. The device provides pulsatile flow, which has been documented to improve clinical outcome (7,8), myocardial blood flow (9) and splanchnic perfusion (10), to reduce systemic vascular resistance and to attenuate catecholamine response (11). In addition, the device functions independent of cardiac rhythm and can provide support during potentially fatal arrhythmias (12,13).…”