Effect of carbonate substitution on physicochemical and biological properties of silver containing hydroxyapatites

Kolmas, Joanna; Piotrowska, Urszula; Kuras, Marzena; Kurek, Eliza

doi:10.1016/j.msec.2017.01.003

Cited by 29 publications

(14 citation statements)

References 35 publications

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“…Pseudomonas are iron-dependent bacteria that produce the water-soluble, yellow-green fluorescent dye, pyoverdine in iron-deficient conditions [ 53 ]. Pseudomonas are also often associated with acute opportunistic infections [ 54 , 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…The samples of each material were examined using the disc diffusion method. The analyzed powders were uniaxially pressed into pellets (φ = 13 mm) and next heated at 180 °C for 3–4 h in air according to our previous paper [ 56 ]. Microbial suspensions of 1.5 × 10 8 CFU/mL corresponding to 0.5 McFarland density obtained from an overnight culture of P. fluorescens developed on TSB were spread onto Petri dishes containing Mueller-Hinton II Agar.…”

Section: Methodsmentioning

confidence: 99%

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Modifications of Hydroxyapatite by Gallium and Silver Ions—Physicochemical Characterization, Cytotoxicity and Antibacterial Evaluation

Pajor

Pajchel

Zgadzaj

et al. 2020

IJMS

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Hydroxyapatite (HA) powders enriched with silver or gallium ions or both were synthesized by two different routes: standard precipitation and the solid-state method. The powders were characterized by using several methods: inductively coupled plasma optical emission spectrometry (ICP-OES), powder X-ray diffractometry (PXRD), transmission electron microscopy (TEM), infrared spectroscopy (FT-IR) and solid-state nuclear magnetic resonance spectroscopy (ssNMR). The effects of enrichment of the HAs in Ag+ or Ga3+ or both on in vitro cytotoxicity and microbiological activity were discussed. PXRD experiments showed that the samples obtained by the wet method consisted of single-phase nanocrystalline HA, while the samples prepared via the solid-state method are microcrystalline with a small amount of calcium oxide. The introduction of higher amounts of silver ions was found to be more effective than enriching HA with small amounts of Ag+. Gallium and silver ions were found not to affect the lattice parameters. Ga3+ affected the crystallinity of the samples as well as the content of structural hydroxyl groups. Among samples synthesized by the wet method, only one (5Ag-HAw) was cytotoxic, whereas all Ga-containing samples obtained by the dry method showed cytotoxicity. In the preliminary antimicrobial test all the materials containing “foreign” ions showed high antibacterial activity.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Modifications of Hydroxyapatite by Gallium and Silver Ions—Physicochemical Characterization, Cytotoxicity and Antibacterial Evaluation

Pajor

Pajchel

Zgadzaj

et al. 2020

IJMS

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“…The most frequently studied combinations concern the addition of silicate SiO 4 4− ions (to improve osteogenic properties) [91] and strontium (Sr 2+ ) ions (to reduce silver cytotoxicity and boost antibacterial properties) [92]. Recently, Aksakal et al [93] examined multiple HA substitutions with silver, zirconia and yttria, while Kolmas et al [94] indicated that co-substitution of Ag-HA with carbonate (CO 3…”

Section: Silver-substituted Hydroxyapatitementioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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“…For example, silicate ions (SiO 4 4− ) stimulate the proliferation of osteoblasts, thus improving the bioactivity of HA [8]. Silver ions have a strong bactericidal effect on most Gram(−) and Gram(+) strains, which can be used in the production of biomaterials with additional antibacterial properties [9].…”

Section: Introductionmentioning

confidence: 99%

Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance

et al. 2018

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Hydroxyapatites (HAs), as materials with a similar structure to bone minerals, play a key role in biomaterials engineering. They have been applied as bone substitute materials and as coatings for metallic implants, which facilitates their osseointegration. One of the beneficial characteristics of HA, when used to create biocompatible materials with improved physicochemical or biological properties, is its capacity for ionic substitution. The aim of the study was to present the current state of knowledge about HAs containing selenate ions IV or VI. The enrichment of HAs with selenium aims to create a material with advantageous effects on bone tissue metabolism, as well as having anticancer and antibacterial activity. The work is devoted to both methods of obtaining Se-HA and an evaluation of its chemical structure and physicochemical properties. In addition, the biological activity of such materials in vitro and in vivo is discussed.Pure, stoichiometric HA crystallizes in a monoclinic system, space group P2 1 /b [5]. However, it is worth mentioning that HA like this is rare and very difficult to obtain by synthesis.

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Effect of carbonate substitution on physicochemical and biological properties of silver containing hydroxyapatites

Cited by 29 publications

References 35 publications

Modifications of Hydroxyapatite by Gallium and Silver Ions—Physicochemical Characterization, Cytotoxicity and Antibacterial Evaluation

Modifications of Hydroxyapatite by Gallium and Silver Ions—Physicochemical Characterization, Cytotoxicity and Antibacterial Evaluation

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance

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