Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids

Garg, Gaurav A; Sao, Prajct P; Khopkar, Uday S

doi:10.4103/0974-2077.79176

Cited by 30 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After thoroughly reading the full text, 56 articles that were inconsistent with the research results were excluded, and ultimately 26 articles were included. 3 , 13 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 The basic characteristics of the included studies are detailed in Table 1 . To obtain the latest pooled results, articles published since 1 January 2010 were merely included.…”

Section: Resultsmentioning

confidence: 99%

Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta‐analysis

Fu,

Duan,

Zhong

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

This meta‐analysis aims to evaluate and compare the effect of surgical excision followed by adjuvant radiotherapy and laser combined with steroids on keloids. Relevant studies reporting the recurrence rate or incidence of adverse events (AEs) were retrieved from the PubMed, Web of Science, Embase and Cochrane Library databases through August 2023. The quality of noncomparative single‐arm clinical trials was evaluated using the methodological index for nonrandomised studies (MINORS) Methodological items. This meta‐analysis was conducted utilizing Stata 12.0 statistical software. 26 studies involving 989 patients were included in the analysis. The recurrence rate in the laser combined with steroids therapy group (12.2%, 95% confidence interval [CI]: 5.9%–18.5%) was lower than that of the surgical excision combined with radiotherapy group (13.5%, 95% CI: 6.6%–22.2%). For the incidence of AEs, relatively low incidence of atrophy (0.0%, 95% CI: 0.0%–1.2%), telangiectasia (3.2%, 95% CI: 0.4%–7.6%), erythema (2.3%, 95% CI: 0.0%–10.6%), infection (0.2%, 95% CI: 0.0%–1.6%) and high hyperpigmentation rate (8.3%, 95% CI: 4.2%–13.4%) were obtained in the surgical excision combined with radiotherapy group. Compared with surgical resection followed by radiotherapy, the combination of laser and steroids for keloids showed a lower hyperpigmentation rate (6.5%), as well as a higher incidence of atrophy (22.7%), telangiectasia (6.4%), erythema (3.3%) and infection (3.3%). Only a hypopigmentation rate of 2.9% was obtained in patients treated with surgical excision plus radiotherapy. Current evidence revealed that surgical excision followed by adjuvant radiotherapy and laser combined with steroids therapy were effective and safe treatments for keloids, with relatively low recurrence rate and complication rate. Comparative studies are needed to further compare the effects of these two combination therapies on keloids.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta‐analysis

Fu,

Duan,

Zhong

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…Previous surveys reported recurrence of the condition via methods like surgical excision or laser therapy . 26 Although recent studies have mentioned combination therapies for keloids like CO2 laser ablation followed by steroid injection, 27 platelet-rich plasma injection with surgical excision, 28 or plasma therapy with radiation therapy, 23 there is no consensus in this regard, and sometimes these combination therapies have led to unsuccessful outcomes or adverse effects. Choosing an effective monotherapy method can be beneficial in this regard.…”

Section: Discussionmentioning

confidence: 99%

Keloid Treatment Using Plasma Exeresis: A Pilot Trial Study

et al. 2023

View full text Add to dashboard Cite

Introduction: Keloid scars and hypertrophic scars are more commonly seen after surgeries, suture placements, or other skin damages. Scars can be treated using a variety of methods, including topical compounds, surgery, and lasers. The aim of this study is to evaluate the effects of plasma exeresis on the treatment of keloid scars. Methods: This experimental study was conducted on patients with keloid scars, defined as a treatment-resistant subtype of scars with extension beyond the primary skin defect and cauliflower appearance, in different parts of the body. The patients were treated with 2-to-3-session plasma exeresis. Scars were examined based on the Vancouver scar scale (VSS) before and 5 months after the treatment. Results: A total number of 24 scars were enrolled in this study. The number of patients was 16. There was a decrease in the mean thickness of keloids from 2.20 to 0.54 (P=0.000). The mean pigmentation and pliability scores decreased from 1.54 and 2.16 to 0.375 and 0.541, respectively (P=0.001, 000). There was a significant reduction in the keloid scar vascularity score from 1.666 to 0.541 (P=0.000). There was a decrease from 0.708 to 0.00 (P=0.004) in the mean itchiness score. After the intervention, the mean pain score was 0.000, compared to 0.7500 before the intervention (P=0.003). There was a decrease in the total score from 8.958 to 2.000 (P=0.000). Conclusion: The plasma exeresis procedure is effective in destroying small keloid scars. Furthermore, results in less itching and pain, as well as no significant complications or recurrences.

show abstract

“…Garg et al evaluated the effect of CO 2 laser ablation followed by steroid injection. 14 Their study illustrated that CO 2 laser alone was not efficient enough while adding steroid injection as adjuvant therapy could significantly reduce recurrence rate. Hersant et al reported a pilot study using platelet-rich plasma injection as adjuvant therapy to surgical excision.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Keloids Using Plasma Skin Regeneration Combined with Radiation Therapy Under the Evaluation of Patient and Observer Scar Assessment Scale

Ting¹,

Chong²,

Xu³

et al. 2021

CCID

View full text Add to dashboard Cite

Keloids are caused by uncontrolled excessive proliferation of fibrous tissue. Multiple treatment strategies including steroid injection, surgical excision, laser therapy and radiation therapy have been reported. Few studies have evaluated the performance of plasma skin regeneration (PSR) in the treatment of keloid. This study aimed to evaluate the effectiveness of PSR combined with radiation therapy for keloids on different body parts. Patients and Methods: A total of 71 patients with 98 keloids were enrolled in this study. Keloids <4 mm thick underwent single-dose PSR, while keloids ≥4 mm thick were administered compound betamethasone injection beforehand. Radiation therapy was administered after 24 hours and again 7 days later after PSR. The outcome was evaluated using the patient and observer scar assessment scale at 12 months post-treatment. Results: Patient-reported average scores for all keloids significantly decreased from 35.05 ±9.94 to 21.84±7.04 (p < 0.05). Keloids on face and neck, chest, and back responded better than those on shoulders and limbs. The recurrence rate was observed to be 15.3% (15 out of 98). Adverse effects were mild. Conclusion: PSR combined with radiation therapy is an effective and safe strategy to treat keloids. Location could be a factor that affects curative effects.

show abstract

Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids

Cited by 30 publications

References 16 publications

Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta‐analysis

Comparison of surgical excision followed by adjuvant radiotherapy and laser combined with steroids for the treatment of keloids: A systematic review and meta‐analysis

Keloid Treatment Using Plasma Exeresis: A Pilot Trial Study

Treatment of Keloids Using Plasma Skin Regeneration Combined with Radiation Therapy Under the Evaluation of Patient and Observer Scar Assessment Scale

Contact Info

Product

Resources

About