Effect of carbohydrate-feeding strategy on the production, physiochemical changes, anti-inflammation activities of polysaccharides of Poria cocos

Lu, Mei-Kuang; Chao, Chi-Hsein; Hsu, Yu-Chi

doi:10.1016/j.ijbiomac.2021.10.017

Cited by 10 publications

(2 citation statements)

References 32 publications

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“…Furthermore, ECG can exert anti-inflammatory, immunomodulatory, and anti-oxidant effects through multiple pathways ( Jayaraman et al, 2012 ; Jiang et al, 2014 ; Yang et al, 2018 ). Similar to ECG, Poria cocos can relieve cough as an expectorant by targeting nuclear factor-κB, mitogen-activated protein kinase, and TGFRII signaling pathway ( Hu et al, 2021b ; Gui et al, 2021 ; Lu et al, 2021 ), whereas Pinellia and Schisandra chinensis perform similar roles in pneumonia by participating in various regulatory pathways in animal models ( Su et al, 2016 ; Yang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Juhongtanke oral solution on alleviating the symptoms of community-acquired pneumonia: A multicenter, prospective, randomized controlled trial

Liang¹,

Hu²,

Luo³

et al. 2022

Front. Pharmacol.

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Introduction: The timely alleviation of symptoms is essential for managing community-acquired pneumonia (CAP). Juhongtanke oral solution is a traditional marketed Chinese patent medicine believed to ease CAP symptoms. The currently available evidence is based on a few retrospective studies of patients with various types of pneumonia, whereas robust randomized controlled trials (RCTs) that support this notion are lacking.Material and methods: In this multi-center, prospective RCT, patients were randomly allocated to receive routine treatment alone or a combination of Juhongtanke oral solution (20 mL q8h) for 5 days and maintained for an additional 3-day safety observation period. The primary outcome was Breathlessness, Cough, and Sputum Scale (BCSS) score evaluated on day 5. Secondary outcomes included the evaluation of cough and dyspnea items in the Visual Analogue Scale (VAS) from days 1–5, remission rate in BCSS and VAS during the treatment course, and the length of hospitalization and in-hospital mortality.Results: Of 272 patients assessed for eligibility, 240 were enrolled in the study (n =120 per group). The mean difference in BCSS evaluated on day 5 was a median 1 point [95%CI (1.00, 2.00)], significantly lower in the treatment group compared with the control group (p < 0.001). Similar results were observed in VAS on day 5, with statistics of a median 2 points [95%CI (1.40, 2.50)] in the cough item and a median 1 point [95%CI (0.50, 2.00)] in the dyspnea item, significantly lower in the treatment group compared with the control group (both p < 0.001). The treatment group had a favorable outcome in BCSS and VAS remission rate assessments compared with the control group, with 99.50% vs. 89.17% in BCSS (p = 0.01), 98.33% vs. 75% in the cough item of VAS (p < 0.001), and 88.33% vs. 62.50% in the dyspnea item of VAS (p < 0.001), respectively. No notable adverse effects were observed during the study. No differences were observed in the length of hospitalization between groups (with a median of 7 days for both groups, p = 0.871).Conclusion: Juhongtanke oral solution may be considered to alleviate the clinical symptoms of CAP.

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Section: Discussionmentioning

confidence: 99%

Effects of Juhongtanke oral solution on alleviating the symptoms of community-acquired pneumonia: A multicenter, prospective, randomized controlled trial

Liang¹,

Hu²,

Luo³

et al. 2022

Front. Pharmacol.

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show abstract

“…Poria cocos , recorded in the chinese pharmacopoeia as an herb, possesses diuretic, detumescent, and detoxifying properties. Previous reports [56][57][58][59] have suggested that triterpenes ,polysaccharides , and steroids are the main chemical components of poria cocos . The mechanism of diterpenesporicoic acid ZF and triterpenes (poricoic acid ZGand poricoic acid ZH ) extracted from poria cocos is to block the interaction among Smad anchor for receptor activation (SARA), TGF-β1, and Smad3 and selectively inhibit the phosphorylation of Smad3.…”

Section: Poria Cocosmentioning

confidence: 95%

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

gengzhen¹,

yaodan²,

chao³

et al. 2022

Preprint

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Chronic kidney disease has emerged as a global public health problem in recent years. Chronic kidney disease progression, characterized by the development of renal fibrosis, leads to end-stage kidney disease. Transforming growth factor β has been shown to play a key role in the mechanism of renal fibrosis. Several studies have shown that individual Chinese herbal extracts can inhibit transforming growth factor β activation and reduce extracellular matrix formation, thereby imparting an anti-renal fibrosis effect through multiple pathways and multiple targets. In the present manuscript, the research trends of single traditional Chinese medicines and extracts in preventing and treating renal fibrosis are summarized, which may be insightful for generating new ideas for preventing and delaying renal fibrosis.

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The function and application of edible fungal polysaccharides

Zhang,

Xu,

Xie

et al. 2024

Advances in Applied Microbiology

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Effect of carbohydrate-feeding strategy on the production, physiochemical changes, anti-inflammation activities of polysaccharides of Poria cocos

Cited by 10 publications

References 32 publications

Effects of Juhongtanke oral solution on alleviating the symptoms of community-acquired pneumonia: A multicenter, prospective, randomized controlled trial

Effects of Juhongtanke oral solution on alleviating the symptoms of community-acquired pneumonia: A multicenter, prospective, randomized controlled trial

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

The function and application of edible fungal polysaccharides

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