1979
DOI: 10.1677/joe.0.0810143
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Effect of Carbenoxolone on the Concentrations of Aldosterone in Rat Plasma and Kidney

Abstract: The renal subcellular distribution of various subcutaneous doses (10\ m=-\ 10\ p=n-\ 10\ m=-\ 8mol) of [3H]aldosterone has been investigated in adrenalectomized rats pretreated with carbenoxolone.Carbenoxolone increased the concentration of plasma [3H]aldosterone, but the uptake of [3H]aldosterone into the kidney nuclear and cytosol fractions was decreased. Pretreatment ofrats with carbenoxolone at low doses of aldosterone (0\ m=. \ 4 \ m=x\10\m=-\10 and 1\ m=. \ 5\ m=x\10\m=-\10mol) decreased both the amount … Show more

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