Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study

Stewardson, Andrew J.; Marimuthu, Kalisvar; Sengupta, Shamik; Allignol, Arthur; El‐Bouseary, Maisra M.; Carvalho, Maria J.; Hassan, Brekhna; Delgado-Ramírez, Mónica A; Arora, Anita; Bagga, Ruchika; Owusu-Ofori, Alex; Ovosi, Joseph Ogirima; Aliyu, Shamsudin; Saad, Hala; Kanj, Souha S.; Khanal, Basudha; Bhattarai, Balkrishna; Saha, Samir K.; Uddin, Jamal; Barman, Purabi; Sharma, Latika; El-Banna, Tarek; Zahra, Rabaab; Saleemi, Mansab Ali; Kaur, Arshdeep; Iregbu, Kenneth; Uwaezuoke, Nkolika Sc; Hanna, Pierre Abi; Feghali, Rita; Corrêa, Ana Lúcia; Múnera, María Isabel; Le, Thi Anh Thu; Tran, Thi Thanh Nga; Phukan, Chimanjita; Valderrama-Beltrán, Sandra; Álvarez-Moreno, Carlos; Walsh, Timothy R.; Harbarth, Stéphan Juergen

doi:10.1016/s1473-3099(18)30792-8

Cited by 152 publications

(120 citation statements)

References 45 publications

(45 reference statements)

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…26 Recently, a multinational prospective cohort study was performed that evaluated the effect of carbapenem resistance on outcomes of bloodstream infections due to Enterobacteriaceae in low-and middle-income countries. 27 This study reports a crude mortality rate of 35% (43/123 patients) for patients with carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infections, similar to other reported rates ranging from 26 to 44%. 28 In addition, the authors found that CRE bloodstream infection was associated with an increased length of hospital stay (3.7 days, 95% CI: 0.3-6.9) and increased probability of in-hospital mortality (hazard ratio: 1.75; 95% CI: 1.04-2.94) compared with carbapenem-sensitive infections.…”

Section: Antibiotic Resistance In Low-and Middle-income Countriessupporting

confidence: 82%

Difficult-to-Treat Antibiotic-Resistant Gram-Negative Pathogens in the Intensive Care Unit: Epidemiology, Outcomes, and Treatment

Strich

Kadri

2019

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Antibiotic resistance among gram-negative pathogens is a world-wide problem that poses a constant threat to patients in the intensive care unit and a therapeutic challenge for the intensivist. Furthermore, the substantial economic burden and increased mortality associated with infections due to highly resistant gram-negative pathogens exacerbate these challenges. Understanding the mechanisms, epidemiology, and risk factors for these infections is paramount to the successful control of outbreaks and for guiding therapy which often entails use of antibiotics with suboptimal efficacy and/or toxicity profiles. In this review we will discuss the global epidemiology, burden, risk factors, and treatment of highly resistant gram-negative infections as they apply to the intensive care population.

show abstract

Section: Antibiotic Resistance In Low-and Middle-income Countriessupporting

confidence: 82%

Difficult-to-Treat Antibiotic-Resistant Gram-Negative Pathogens in the Intensive Care Unit: Epidemiology, Outcomes, and Treatment

Strich

Kadri

2019

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…Increased hospital stay and mortality was shown to be associated with CRE infection in a recent published study. 32 In hospitals that were screened both 2017 and 2018, the increase in CRE prevalence was considerable. This indicates that improvement in IPC measures is urgent, otherwise we may not have seen the peak of this hospital epidemic.…”

Section: Main Findingsmentioning

confidence: 99%

High prevalence of colonisation with carbapenem-resistant Enterobacteriaceae among patients admitted to Vietnamese hospitals: Risk factors and burden of disease

Tran

Larsson

Olson

et al. 2019

Journal of Infection

View full text Add to dashboard Cite

show abstract

“…However, since their discovery, carbapenemases (e.g., NDM, KPC, and OXA) have emerged as key drivers of carbapenem resistance across various Gram-negative bacterial species [2,3]. Lack of effective treatment and the consequent high mortality [4] has increased emphasis on the prevention of MDRGN transmission. Prevention toolkits and guidelines have been drawn up by various organizations to harness the principles of infection control and prevention to break the chain of transmission and control the spread of MDRGN [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms

Chia

Sengupta

Kukreja

et al. 2020

Antimicrob Resist Infect Control

Self Cite

View full text Add to dashboard Cite

Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to the healthcare system worldwide. In recent years, increasing evidence supports the association between the healthcare environment and transmission of MDRGN to patients and healthcare workers. To better understand the role of the environment in transmission and acquisition of MDRGN, we conducted a utilitarian review based on literature published from 2014 until 2019.

show abstract

Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study

Abstract: 2019. Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in lowincome and middle-income countries (PANORAMA): a multinational prospective cohort study. Lancet Infectious Diseases 19 (6) , pp.

Cited by 152 publications

References 45 publications

Difficult-to-Treat Antibiotic-Resistant Gram-Negative Pathogens in the Intensive Care Unit: Epidemiology, Outcomes, and Treatment

Difficult-to-Treat Antibiotic-Resistant Gram-Negative Pathogens in the Intensive Care Unit: Epidemiology, Outcomes, and Treatment

High prevalence of colonisation with carbapenem-resistant Enterobacteriaceae among patients admitted to Vietnamese hospitals: Risk factors and burden of disease

The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms

Contact Info

Product

Resources

About