Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson’s disease

Siddique, Yasir Hasan; Naz, Falaq; Jyoti, Smita

doi:10.1556/018.69.2018.2.1

Cited by 23 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These PD flies displayed a progressive form of neurodegeneration characterized by loss of dopamine function, oxidative stress and impaired performance in the climbing assay. Reversal of the pathological changes occurred in a dose-dependent manner which confirmed the therapeutic potential of capsaicin through TRPV1 activation for PD treatment (Siddique et al, 2012(Siddique et al, , 2018.…”

Section: Trpv1supporting

confidence: 59%

Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson’s Disease: An Insight Into Role of Pharmacological Interventions

Vaidya

Sharma

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the symptoms of motor deficits and cognitive decline. There are a number of therapeutics available for the treatment of PD, but most of them suffer from serious side effects such as bradykinesia, dyskinesia and on-off effect. Therefore, despite the availability of these pharmacological agents, PD patients continue to have an inferior quality of life. This has warranted a need to look for alternate strategies and molecular targets. Recent evidence suggests the Transient Receptor Potential (TRP) channels could be a potential target for the management of motor and non-motor symptoms of PD. Though still in the preclinical stages, agents targeting these channels have shown immense potential in the attenuation of behavioral deficits and signaling pathways. In addition, these channels are known to be involved in the regulation of ionic homeostasis, which is disrupted in PD. Moreover, activation or inhibition of many of the TRP channels by calcium and oxidative stress has also raised the possibility of their paramount involvement in affecting the other molecular mechanisms associated with PD pathology. However, due to the paucity of information available and lack of specificity, none of these agents have gone into clinical trials for PD treatment. Considering their interaction with oxidative stress, apoptosis and excitotoxicity, TRP channels could be considered as a potential future target for the treatment of PD.

show abstract

Section: Trpv1supporting

confidence: 59%

Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson’s Disease: An Insight Into Role of Pharmacological Interventions

Vaidya

Sharma

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…In our study the PD flies showed the loss of memory as measured by performing aversive phototaxis assay. The natural plant products have been shown to improve the memory functions in various experimental models 48 – 50 . Based on the results obtained in our present study the possible mode of protection by kaempferol has been depicted in Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of kaempferol on the transgenic Drosophila model of Parkinson’s disease

Rahul

Naz

Jyoti

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

The present study was aimed to study the effect of kaempferol, on the transgenic Drosophila model of Parkinson's disease. Kaempferol was added in the diet at final concentration of 10, 20, 30 and 40 µM and the effect was studied on various cognitive and oxidative stress markers. The results of the study showed that kaempferol, delayed the loss of climbing ability as well as the activity of PD flies in a dose dependent manner compared to unexposed PD flies. A dose-dependent reduction in oxidative stress markers was also observed. Histopathological examination of fly brains using anti-tyrosine hydroxylase immunostaining has revealed a significant dose-dependent increase in the expression of tyrosine hydroxylase in PD flies exposed to kaempferol. Molecular docking results revealed that kaempferol binds to human alpha synuclein at specific sites that might results in the inhibition of alpha synuclein aggregation and prevents the formation of Lewy bodies.

show abstract

“…Lemons can protect from Alzheihmer's disease by decreasing the MAO activity (Oyeleye et al, 2021). Capsaicin can also reduce the MAO activity in the Parkinson's model of D. melanogaster (Siddique et al, 2018). MAO can be quantified following Mcewen (McEwen, 1965).…”

Section: Biochemical Assaysmentioning

confidence: 99%

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Mishra¹,

PANDA²,

Barik³

et al. 2023

Biocell

View full text Add to dashboard Cite

Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a delay in developmental time, defective growth, structural abnormality of many organs, including sensory organs, behavioral abnormalities, or death in the fetus stage. Numerous model organisms are employed to assess the effect of neurotoxicants. The current review summarizes several methods used to check the effect of neurotoxicant and their effect using the model organism Drosophila melanogaster.

show abstract

Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson’s disease

Cited by 23 publications

References 37 publications

Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson’s Disease: An Insight Into Role of Pharmacological Interventions

Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson’s Disease: An Insight Into Role of Pharmacological Interventions

Effect of kaempferol on the transgenic Drosophila model of Parkinson’s disease

Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds

Contact Info

Product

Resources

About