Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial

Narang, Gopal; Moore, Jonathan E.; Wymer, Kevin; Chang, Yu‐Hui; Lim, Elisabeth S.; Adeleye, Olufunmilola; Humphreys, Mitchell R.; Stern, Karen

doi:10.1097/ju.0000000000003139

Cited by 15 publications

(12 citation statements)

References 20 publications

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“…Narang et al (page 726) from Phoenix, Arizona, report a randomized, blinded, placebo-controlled trial to determine the safety and efficacy of a Food and Drug Administration–approved CBD oil as part of a multimodal approach including rescue opioids. 3 This well-performed trial demonstrated that the CBD oil was safe but ineffective in any of the end points studied and, importantly, did not mitigate opioid usage. Although only 90 patients were randomized, the use of CBD oil, at least in this dose and formulation, does not appear to have much benefit for patients with the aggravating but short-term discomfort from stents.…”

Section: Cannabidiol Oil For Pain Control After Ureteroscopymentioning

confidence: 87%

This Month in Adult Urology

Siemens

2023

Journal of Urology

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Section: Cannabidiol Oil For Pain Control After Ureteroscopymentioning

confidence: 87%

This Month in Adult Urology

Siemens

2023

Journal of Urology

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“…Dizziness was more common in the CBD group; other side effects included tiredness, constipation, drowsiness, and poor sleep. 142…”

Section: Clinical Studies Evaluating Cbd For Painmentioning

confidence: 99%

An Overview of Cannabidiol

Sideris,

Doan

2023

Anesthesia &Amp; Analgesia

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Cannabidiol (CBD) is one of the most interesting constituents of cannabis, garnering significant attention in the medical community in recent years due to its proven benefit for reducing refractory seizures in pediatric patients. Recent legislative changes in the United States have made CBD readily available to the general public, with up to 14% of adults in the United States having tried it in 2019. CBD is used to manage a myriad of symptoms, including anxiety, pain, and sleep disturbances, although rigorous evidence for these indications is lacking. A significant advantage of CBD over the other more well-known cannabinoid delta-9-tetrahydroncannabinol (THC) is that CBD does not produce a “high.” As patients increasingly self-report its use to manage their medical conditions, and as the opioid epidemic continues to drive the quest for alternative pain management approaches, the aims of this narrative review are to provide a broad overview of the discovery, pharmacology, and molecular targets of CBD, its purported and approved neurologic indications, evidence for its analgesic potential, regulatory implications for patients and providers, and future research needs.

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“…To the Editor: We read with interest the article “Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial.” 1 We commend the authors for a well-conducted clinical trial and acknowledge their effort in reporting a negative result with utmost diligence.…”

mentioning

confidence: 99%