Effect of camel milk on glycaemic control and lipid profile of patients with type 2 diabetes: Randomised controlled clinical trial

Fallah, Zahra; Ejtahed, Hanieh‐Sadat; Mirmiran, Parvin; Niasari-Naslaji, Amir; Moosavi-Movahedi, Ali Akbar; Azizi, Fereidoun

doi:10.1016/j.idairyj.2019.104568

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…A total of 21 articles were then selected for full-text screening, out of which 7 articles were excluded due to insufficient data reporting of the outcome measures of interest. Fourteen articles [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ] were therefore included in the quantitative meta- and sub-group analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Intake dosage varied between 250 mL and 500 mL daily or twice a week. The type of CM intake as described in 14 studies: fresh [ 32 , 33 , 35 , 37 , 39 , 40 , 41 , 42 , 44 , 45 ], fermented [ 38 ] and pasteurized [ 36 , 43 ]. Studies were accomplished in India [ 32 , 33 , 35 ], Iran [ 36 , 37 , 38 , 41 ], Yemen [ 39 ], Sudan [ 40 ], Egypt [ 42 ], Saudi Arabia [ 43 ], Libya [ 44 ], and China [ 45 ], and were published between 2003 and 2021.…”

Section: Resultsmentioning

confidence: 99%

“…The type of CM intake as described in 14 studies: fresh [ 32 , 33 , 35 , 37 , 39 , 40 , 41 , 42 , 44 , 45 ], fermented [ 38 ] and pasteurized [ 36 , 43 ]. Studies were accomplished in India [ 32 , 33 , 35 ], Iran [ 36 , 37 , 38 , 41 ], Yemen [ 39 ], Sudan [ 40 ], Egypt [ 42 ], Saudi Arabia [ 43 ], Libya [ 44 ], and China [ 45 ], and were published between 2003 and 2021. In the current meta-analysis, the control group that received the usual care of diabetes was used as the comparators in all the included studies.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2022

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The effects of camel milk (CM) intake on glycemic control in patients with diabetes are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of CM intake on glucose homeostasis parameters in patients with both types of diabetes mellitus; T1DM and T2DM. We searched Google Scholar, PubMed/MEDLINE, EBSCO host, CINAHL, ScienceDirect, Cochrane, ProQuest Medical, Web of Science, and Scopus databases from inception until the end of November 2021. Relevant RCTs were identified, and the effect size was reported as mean difference (MD) and standard deviation (SD). Parameters of glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting serum insulin (FI), insulin resistance (expressed in terms of HOMA-IR), insulin dose (ID) received, serum insulin antibody (IA), and C-peptide (CP) were tested. Out of 4054 collected articles, 14 RCTs (total 663 subjects) were eligible for inclusion. The pooled results obtained using a random-effects model showed a statistically significant decrease in HbA1c levels (MD, −1.24, 95% confidence interval (CI): −2.00, −0.48, p < 0.001 heterogeneity (I2) = 94%) and ID received (MD, −16.72, 95% CI: −22.09, −11.35 p < 0.00001, I2 = 90%), with a clear tendency was shown, but non-significant, to decrease FBG (MD, −23.32, 95% CI: −47.33, 0.70, p = 0.06, I2 = 98%) in patients with diabetes who consumed CM in comparison to those on usual care. Conversely, the consumption of CM did not show significant reductions in the rest of the glucose homeostasis parameters. Subgroup analysis revealed that patients with T2DM were more beneficially affected by CM intake than those with T1DM in lowering FBG, while patients with T1DM were more beneficially affected by CM intake than those with T2DM in lowering HbA1c. Both fresh and treated (pasteurized/fermented) CM gave similar beneficial effects in lowering HbA1c. Lastly, a relatively superior effect for longer duration on shorter duration (>6 months, ≤6 months, respectively) of CM intake is found in lowering HbA1c. To conclude, long-term consumption of CM by patients with diabetes could be a useful adjuvant therapy alongside classical medications, especially in lowering the required insulin dose and HbA1c. Due to the high heterogeneity observed in the included studies, more controlled trials with a larger sample size are warranted to confirm our results and to control some confounders and interfering factors existing in the analyzed articles.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2022

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“…Camel is a domesticated animal, which is an important resource of food in many countries of the world including the Middle East. The health benefits of camel milk are associated with its antimicrobial (Abdel‐Hamid et al., 2016), dislipedemic (Mohammaddin et al., 2018), antidiabetic (Fallah et al., 2020), and anticancer (Abrhaley & Leta, 2018) properties, and its richness of minerals and vitamins (Swelum et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Detection of multimycotoxins in camel feed and milk samples and their comparison with the levels in cow milk

Zeidan

Hassan

Al‐Naimi

et al. 2021

Food Science & Nutrition

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Camel milk has been considered as an important source of nutrients and is commercialized in many countries of the world including the Middle East. This study aimed to investigate the presence of mycotoxins in camel feed and milk samples in comparison with the cow milk. Fumonisins (FUM), ochratoxin A (OTA), and zearalenone (ZEN) were detected in 14%, 39%, and 39% of the tested camel feed samples, respectively. Among the tested camel feed samples, 8.3% and 5.6% were co‐contaminated with OTA+FUM and FUM+ZEN, respectively. In the case of milk samples, 46.15% of camel and 63.63% of cow were found contaminated with aflatoxin M1 (AFM1). In total, 16.2% and 8.1% of the milk samples were simultaneously contaminated with two and three mycotoxins, respectively. Although the levels of individual mycotoxins in the camel feed and milk samples were within the European Union (EU) permissible limits, their co‐occurrence may pose severe risk to human and animal health due to possible additive and/or synergistic toxicities.

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“…Furthermore, camel milk has a signi cant in uence on insulin receptor function and glucose transfer in insulin-sensitive organs such as the liver and pancreas, both of which play key roles in the maintenance of blood glucose homeostasis (Al-Hashem et al 2009). On the contrary, (Fallah et al 2020) discovered that the hypoglycemic bene ts of camel milk on type 2 diabetes patients can only be sustained when combined with diabetic medicines. Furthermore, (Ejtahed et al 2015) discovered no change in glucose, lipids, or blood pressure parameters after consuming camel or cow's milk.…”

Section: Discussionmentioning

confidence: 99%

Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-induced C57BL/6J Diabetic Mice

Abdelazez

Alshehry‏

Algarni

et al. 2022

Preprint

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Diabetes is a serious disease that threatens human health worldwide. The study hypothesis is to investigate the novel trends that may aid in the prevention of diabetic complications. Camel milk was presented as a functional food, and Lactobacillus brevis (KLDS1.0727 and KLDS1.0373) strains were shown to synthesize postbiotic GABA as a potential food additive, which can therapeutically intervene against hyperglycemia and hyperlipidemia in streptozotocin-induced C57BL/6 mice. During a four-week timeframe, body weight and postprandial blood glucose levels were monitored. Post euthanasia, blood plasma was obtained to investigate hyperlipidemia, insulin concentrations, liver, and renal functions. The liver, pancreas, kidney, and spleen underwent histological examinations. The results demonstrated that KLDS1.0727 and KLDS1.0373 (LACS1, LACS2), and camel milk treatments all had a significant influence on hypoglycemic activity, as evidenced by reduced postprandial blood glucose levels. LACS1, LACS2, and camel milk therapy significantly reduced blood hypolipidemic, ALT, and AST levels. Camel milk is recommended for its therapeutic benefits in the treatment of hyperglycemia and hyperlipidemia in the management of diabetes and comorbidities as well as, GABA which is considered a potential food additive.

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Effect of camel milk on glycaemic control and lipid profile of patients with type 2 diabetes: Randomised controlled clinical trial

Cited by 12 publications

References 16 publications

Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of Camel Milk on Glucose Homeostasis in Patients with Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Detection of multimycotoxins in camel feed and milk samples and their comparison with the levels in cow milk

Postbiotic Gamma-Aminobutyric Acid and Camel Milk Intervention as Innovative Trends Against Hyperglycemia and Hyperlipidemia in Streptozotocin-induced C57BL/6J Diabetic Mice

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