Effect of camel milk on residual β-cell function in recent onset type 1 diabetes

Agrawal, R P; Saran, Sonal; Sharma, Poornima; Gupta, Ranjana; Kochar, Dhanpat Kumar; Sahani, M. S.

doi:10.1016/j.diabres.2007.01.012

Cited by 64 publications

(74 citation statements)

References 6 publications

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“…The potential hypoglycemic effect of camel milk observed in the current work was not out of expectation with respect to the highest insulin content obtained for camel milk as revealed from the data in Table 3. These findings is consistent with the observation of Agrawal et al (2002), Agrawal et al (2007) and Hamad et al (2011) for hypoglycemic effect of camel milk. It should be noted that, camel milk does not form coagulum in acidic environment of stomach, which may in turn provides a rapid pass of camel milk with its specific like protein/insulin through stomach and remains available for absorption in intestine (Hamad et al 2011).…”

Section: Discussionsupporting

confidence: 93%

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

2013

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The unique characters of camel’s milk make it used extensively in the field of medicine as anti-microbial, anti-diabetic and hepatoprotective agent. The lack of studies demonstrating the protective effect of camel’s milk against hepatotoxic compound was the main reason beyond the conduction of the current experiment which aimed to investigate the protective effects of camel’s milk against carbontetrachloride (CCl4) induced hepatotoxicity. Therefore, 24 rats were fed on standard diet and divided into four groups. Rats of the first group and second groups were injected i/p with paraffin oil and received either tap water (control 1) or camel’s milk (control 2), respectively. Rats of the third and fourth groups were injected i/p with CCl4 and received either tap water or camel’s milk, respectively. At the end of the experiment (5 weeks), blood and liver samples were collected for biochemical and histopathological analysis. The present findings revealed that, CCl4 elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the treatment of rats with camel milk. Histopathologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl4 treated group. The present study concluded that camel milk treatment may play a protective role against CCl4-induced liver damages in rats. These protective effects were in the form of improving of liver enzyme activities, blood biochemical parameters and histological picture of liver of intoxicated rats. In the future, examination of the liver protective effect of camel milk against CCl4 in dose dependant manner could be investigated.

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Section: Discussionsupporting

confidence: 93%

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

2013

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“…These were related to various factors, including the presence of high concentration of insulin/insulin like substances in camel milk, such as halfcystine (Agrawal et al, 2003;Beg, Bahr-Lindström, Zaidi, & Jörnvall, 1986). The effect of small size immunoglobulins of camel milk on bcell (Agrawal et al, 2007a(Agrawal et al, , 2007b and the lack of coagulation of camel milk in the human stomach (Agrawal et al, 2003) have also contributed to the hypoglycaemic effect.…”

Section: Hypoglycaemic Effectmentioning

confidence: 96%

Compositional, technological and nutritional aspects of dromedary camel milk

haj¹,

Kanhal²

2010

International Dairy Journal

342

154

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“…For many centuries, desert dwellers have used camels for transportation and as a source of food, but in addition, camel milk and urine have also been used as medicines to treat various ailments including cancer, chronic hepatitis, hepatitis C and peptic ulcers . Reports also claim that camel milk can cure severe food allergies in children unresponsive to more conventional treatments and aid in the management of diabetes and its complications . For example, in a dog model of alloxan‐induced diabetes, 3‐week consumption of camel milk resulted in a statistically significant decrease in blood glucose, total protein and cholesterol .…”

Section: Introductionmentioning

confidence: 99%

Through the eye of an electrospray needle: mass spectrometric identification of the major peptides and proteins in the milk of the one‐humped camel (Camelus dromedarius)

et al. 2013

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The milk of the one-humped camel (Camelus dromedarius) reportedly offers medicinal benefits, perhaps because of its unique bioactive components. Milk proteins were determined by (1) two-dimensional gel electrophoresis and peptide mass mapping and (2) liquid chromatography-tandem mass spectrometry (LC-MS/MS) following one-dimensional polyacrylamide gel electrophoresis. Over 200 proteins were identified: some known camel proteins including heavy-chain immunoglobulins and others exhibiting regions of exact homology with proteins from other species. Indigenous peptides were also identified following isolation and concentration by two strategies: (1) gel-eluted liquid fraction entrapment electrophoresis and (2) small-scale electrophoretic separation. Extracts were analyzed by LC-MS/MS and peptides identified by matching strategies, by de novo sequencing and by applying a sequence tag tool requiring similarity to the proposed sequence, but not an exact match. A plethora of protein cleavage products including some novel peptides were characterized. These studies demonstrate that camel milk is a rich source of peptides, some of which may serve as nutraceuticals.

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Effect of camel milk on residual β-cell function in recent onset type 1 diabetes

Cited by 64 publications

References 6 publications

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

Compositional, technological and nutritional aspects of dromedary camel milk

Through the eye of an electrospray needle: mass spectrometric identification of the major peptides and proteins in the milk of the one‐humped camel (Camelus dromedarius)

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