Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial

Stout, Jeffrey R.; Smith‐Ryan, Abbie E.; Fukuda, David H.; Kendall, Kristina L.; Moon, Jordan R.; Hoffman, Jay R.; Wilson, Jacob M.; Oliver, Jeffery; Mustad, Vikkie A.

doi:10.1016/j.exger.2013.08.007

Cited by 100 publications

(130 citation statements)

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“…The immediate treatment effects of PS combined with RET and the clinical outcomes within 16 wk (at the midpoint assessment or after the end of the treatment protocol) were reported by 16 RCTs (13, 18-22, 24, 25, 27, 29-34, 37); the various treatment protocols comprised 12-48 sessions within an overall 4-to 16-wk intervention period. Clinical outcomes at 24 wk, after the end of the treatment protocol, were reported by 6 RCTs (13,19,22,(24)(25)(26). None of the included RCTs reported outcomes for periods .6 mo.…”

Section: Ret Protocolmentioning

confidence: 99%

“…Björkman et al (29) trained their participants by instructing them to perform chair rise tasks with maximal effort as many times as they could. Thirteen RCTs involved the training of the whole body, defined as the upper and lower extremities and trunk (13, 18-22, 25, 27, 30-33, 37), whereas the other 4 involved the training of the lower extremities only (Table 1) (24,26,29,34).…”

Section: Ret Protocolmentioning

confidence: 99%

“…In 14 RCTs, participants in the control groups received a placebo supplement and maintained their habitual diet (13,18,20,21,(24)(25)(26)(27)(29)(30)(31)(32)(33)(34), whereas the control groups in the other 3 trials were given RET only and no placebo supplement (19,22,37).…”

Section: Ps Characteristicsmentioning

confidence: 99%

“…Six RCTs used a long intervention period of $24 wk, totaling 48-72 sessions (13,19,22,(24)(25)(26); 8 used a medium intervention period of $12 wk but ,24 wk, totaling 24-48 sessions (18,20,21,27,31,33,34,37); and 3 used a short intervention period of ,12 wk, totaling 12-56 sessions (29,30,32). Most of the included RCTs used a training intensity of 50-80% of participants' one repetition maximum (1-RM) (13, 18, 25-27, 30-34, 37).…”

Section: Ret Protocolmentioning

confidence: 99%

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Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis

Liao

Tsauo

et al. 2017

The American Journal of Clinical Nutrition

221

170

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Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a beneficial effect on muscle protein synthesis and can be augmented by protein supplementation (PS). However, whether body weight affects the augmentation of muscular and functional performance in response to PS in older people undergoing RET remains unclear. Objective: This study was conducted to identify the effects of PS on the body composition and physical function of older people undergoing RET. Design: We performed a comprehensive search of online databases to identify randomized controlled trials (RCTs) reporting the efficacy of PS for lean mass gain, strength gain, and physical mobility improvements in older people undergoing RET. Results: We included 17 RCTs; the overall mean 6 SD age and body mass index (BMI; in kg/m 2 ) in these RCTs were 73.4 6 8.1 y and 29.7 6 5.5, respectively. The participants had substantially greater lean mass and leg strength gains when PS and RET were used than with RET alone, with the standard mean differences (SMDs) being 0.58 (95% CI: 0.32, 0.84) and 0.69 (95% CI: 0.39, 0.98), respectively. The subgroup of studies with a mean BMI $30 exhibited substantially greater lean mass (SMD: 0.53; 95% CI: 0.19, 0.87) and leg strength (SMD: 0.88; 95% CI: 0.42, 1.34) gains in response to PS. The subgroup of studies with a mean BMI ,30 also exhibited relevant gains in response to PS. Conclusions: Compared with RET alone, PS combined with RET may have a stronger effect in preventing aging-related muscle mass attenuation and leg strength loss in older people, which was found in studies with a mean BMI $30 and in studies with a mean BMI ,30. Clinicians could use nutrition supplement and exercise strategies, especially PS plus RET, to effectively improve the physical activity and health status of all older patients.Am J Clin Nutr 2017;106:1078-91.

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Section: Ret Protocolmentioning

confidence: 99%

Section: Ret Protocolmentioning

confidence: 99%

Section: Ps Characteristicsmentioning

confidence: 99%

Section: Ret Protocolmentioning

confidence: 99%

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Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis

Liao

Tsauo

et al. 2017

The American Journal of Clinical Nutrition

221

170

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“…There is also evidence that optimal nutritional supplementation improves muscle quality. Several studies have demonstrated the beneficial effects of essential amino acid (EAA), 124 β-hydroxy-β-methylbutyric acid (HMB), 125 as well as vitamin D and leucine-enriched whey protein nutritional supplement 126 in muscle mass and physical performance. Optimal nutritional supplementation may also enhance the anabolic effect of resistance training.…”

Section: Management Of Sarcopenia To Improve Quality Of Lifementioning

confidence: 99%

Management of Sarcopenia to Improve Quality of Life in Geriatric Populations

Zhu²,

Chan³

et al. 2016

Clinical Medicine Insights: Geriatrics

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Sarcopenia, characterized by a progressive loss of skeletal muscle mass and strength that occurs with advancing age, has been associated with falls, fracture, disability, and mortality. Depending on the definitions used, the prevalence in 60-to 80-year old population is reported as 0.9%-35.9%, while the prevalence ranges from 7%-70.0% in people older than 80 years. Sarcopenia has been associated with lower quality of life. Well-designed exercise interventions, particularly resistance training as well as nutritional supplementation, have been proved to improve muscle strength and performance in geriatric populations. Resistance training may also enhance quality of life. However, there are limited data on the effects of nutritional supplementation as an intervention on quality of life among individuals with sarcopenia. This review briefly summarizes the relationship between sarcopenia and quality of life and presents the potential of interventions to improve muscle quality, physical performance, and quality of life. ACADEMIC EDITOR: atsushi sakuraba, editor in Chief PEER REVIEW: three peer reviewers contributed to the peer review report. Reviewers' reports totaled 497 words, excluding any confidential comments to the academic editor.FUNDING: authors disclose no external funding sources. COMPETING INTERESTS: Authors disclose no potential conflicts of interest.COPYRIGHT: © the authors, publisher and licensee libertas academica limited.this is an open-access article distributed under the terms of the Creative Commons CC-BY-nC 3.0 license. CORRESPONDENCE: rubyyu@cuhk.edu.hkPaper subject to independent expert single-blind peer review. all editorial decisions made by independent academic editor. Upon submission manuscript was subject to anti-plagiarism scanning. Prior to publication all authors have given signed confirmation of agreement to article publication and compliance with all applicable ethical and legal requirements, including the accuracy of author and contributor information, disclosure of competing interests and funding sources, compliance with ethical requirements relating to human and animal study participants, and compliance with any copyright requirements of third parties. this journal is a member of the Committee on Publication ethics (COPe).Provenance: the authors were invited to submit this paper.Published by libertas academica. learn more about this journal. SarcopeniaSarcopenia, defined as a geriatric syndrome characterized by a progressive loss of skeletal muscle mass and strength that occurs with advancing age, was first introduced by Rosenberg in 1989.1,2 The decline in muscle mass occurs after the age of 30 years.3,4 After the age of 50 years, muscle mass is reported to decline at an annual rate of approximately 0.2%; 5 after 70 years, the decline may accelerate to 0.6%-1% per year. [6][7][8] Over the past few decades, refining the definition of sarcopenia has led to significant variation in the meaning. Initially, the definition consists of the measurement of appendicular mass divided...

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Beta‐hydroxy‐beta‐methylbutyrate (HMB) and Sarcopenia

et al. 2021

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Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial

Abstract: CaHMB improved strength and MQ without RE. Further, RE is an effective intervention for improving all measures of body composition and functionality.

Cited by 100 publications

References 34 publications

Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis

Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis

Management of Sarcopenia to Improve Quality of Life in Geriatric Populations

Beta‐hydroxy‐beta‐methylbutyrate (HMB) and Sarcopenia

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