Effect of Calcium Pantothenate and Para-Aminobenzoic Acid on the Gray Hair of Humans

Brandaleone, Harold; Main, Elizabeth; Steele, J. Murray

doi:10.3181/00379727-53-14179p

Cited by 11 publications

(4 citation statements)

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“…[68] Brandaleone et al, however, used 200 mg of PABA with 100 mg of calcium pantothenate (vitamin B5) and 50 g of brewer's yeast for 8 months to patients with gray hair without any success. [69] Pavithran et al reported PUVASOL to be effective in almost two-thirds of patients with premature graying. [70] Repigmentation of previously gray scalp hair has been reported following prolonged (around 3 years) use of latanoprost, a PGF 2 alpha eye drops.…”

Section: Management Managementmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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Premature graying is an important cause of low self-esteem, often interfering with socio-cultural adjustment. The onset and progression of graying or canities correlate very closely with chronological aging, and occur in varying degrees in all individuals eventually, regardless of gender or race. Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes. It needs to be differentiated from various genetic hypomelanotic hair disorders. Reduction in melanogenically active melanocytes in the hair bulb of gray anagen hair follicles with resultant pigment loss is central to the pathogenesis of graying. Defective melanosomal transfers to cortical keratinocytes and melanin incontinence due to melanocyte degeneration are also believed to contribute to this. The white color of canities is an optical effect; the reflection of incident light masks the intrinsic pale yellow color of hair keratin. Full range of color from normal to white can be seen both along individual hair and from hair to hair, and admixture of pigmented and white hair is believed to give the appearance of gray. Graying of hair is usually progressive and permanent, but there are occasional reports of spontaneous repigmentation of gray hair. Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, there is paucity of effective evidence-based treatment options. Reports of repigmentation of previously white hair following certain inflammatory processes and use of drugs have suggested the possibility of cytokine-induced recruitment of outer sheath melanocytes to the hair bulb and rekindled the hope for finding an effective drug for treatment of premature canities. In the end, camouflage techniques using hair colorants are outlined.

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Section: Management Managementmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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“…Significant recoloration was seen in two patients in the PABA+ cal. pantothenate + brewer's yeast arm 12 . Another study by Pasricha et al, where two adolescent girls were given 200 mg calcium pantothenate orally, which led to the conversion into black hairs 13 .…”

Section: Resultsmentioning

confidence: 99%

“…Regarding pharmacotherapy of PGH, although many agents, for example, p‐amino benzoic acid, 15 calcium pantothenate, 12,13 palmitoyl tetrapeptide‐20 lotion, 16 anti‐aging compounds, 2 and herbal agents 17 have been used, the grades of recommendation are low (Table 1). However due to low efficacy of the existing treatment modalities, hair colorants remain the mainstay of management.…”

Section: Discussionmentioning

confidence: 99%

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Mahendiratta

Sarma

Kaur

et al. 2020

Dermatologic Therapy

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Premature graying of hair (PGH) being a very common entity for which pharmacotherapy and reversibility are not properly addressed. Therefore, this systematic review was conducted to address these issues. For this relevant study were selected from various databases including PubMed, EMBASE, OVID, Web of science, Scopus, and Google Scholar till January 20, 2019. Studies which reported risk factors, co-morbid conditions associated with PGH, its pharmacotherapy and reversal were included in the study. Although many risk factors are reported in literature, smoking, vitamin deficiency (B12, folic acid, and B7), mineral deficiency (low serum calcium and serum ferritin) are found to be associated with PGH. Other important risk factors are family history of PGH, obesity, high B.P, lack of exercise, drugs, genetic syndromes, dyslipidemia, thyroid disorders, hyperuricemia, and alteration in liver function. PGH is found to be an important marker of CAD, more so in case of smoker. Among different pharmacotherapeutic management options, low grade recommendation (2A) is given to calcium pantothenate, PABA, calcium pantothenate + PABA combination. Anu-tailam is the only herbal agent evaluated in clinical research settings. Finally, treating the accompanying pathologies led to the reversal of the disease in many cases. K E Y W O R D S co-morbidities, premature graying of hair, reversal, risk factors, treatment 1 | INTRODUCTION Hair graying is a part of aging, which typically starts around 34.2 ± 9.6 years (whites) to 43.9 ± 10.3 years (in blacks). 1 Premature graying of hair (PGH) is said to occur if hair graying starts before the age of 20 (Caucasians) and 30 years in Africans. 1-4 For Indian people, a cut off range of 25 years is suggested. 1,5 DOPA oxidase positive follicular melanocytes are the primary site of pigment production. Hair color basically depends on the eumelanin Abbreviations: BMD, bone mineral density; BMI, body mass index; CAD, coronary artery disease; DBP, diastolic blood pressure; FBS, fasting blood sugar; OR, odds ratio; PABA, paraamino benzoic acid; PGH, premature graying of hair; RCT, randomized controlled trials; SBP, systolic blood pressure; TERT, telomerase reverse transcriptase. Saniya Mahendiratta and Phulen Sarma have contributed equally to this study and both are considered as first authors.

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“…[23] Calcium pantothenate has also been found to be effective in a study conducted by Pasricha [24] on the other hand, there are also contrasting studies in the literature mentioning no results with PABA and calcium pantothenate. [25] Pavithran found positive results of PUVASOL in premature graying of hair with complete repigmentation in 45% of the cases. [26] Bellandi et al observed reversal of gray hair in patients who were on latanoprost for a long duration of time.…”

Section: Investigationsmentioning

confidence: 99%

Premature graying of hair: A concise review

Singh

Madke

Bansod³

et al. 2021

CSDM

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Authors have attempted to provide a short concise and clinically relevant review on premature graying of hairs with the focus of updated pathogenesis, rational investigations, and treatment options. Premature graying of hairs is a fairly common clinical condition faced by dermatologists, however, very scarce therapeutic options are available for successful management of gray hairs. The role of antioxidants is not yet established firmly in the therapeutic armamentarium of premature graying of hairs. Authors have summarized the currently available therapeutic options for the treatment of premature graying of hairs.

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Effect of Calcium Pantothenate and Para-Aminobenzoic Acid on the Gray Hair of Humans

Cited by 11 publications

References 0 publications

Premature graying of hair

Premature graying of hair

Premature graying of hair: Risk factors, co‐morbid conditions, pharmacotherapy and reversal—A systematic review and meta‐analysis

Premature graying of hair: A concise review

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