Abstract:Dietary supplements that prevent bone loss at the hip and that can be applied safely in the elderly are likely to reduce hip fractures. A daily dietary supplement of 750 mg calcium or 15 microg 25OH vitamin D3 on bone loss at the hip and other sites, bone turnover and calcium-regulating hormones were studied over 4 yr in elderly volunteers using a randomized, double-blind, placebo-controlled trial. Bone mineral density (BMD) was measured by dual x-ray absorptiometry and bone structure by radiographs. Calcium b… Show more
“…In comparison with calcium, few clinical trials have focused on vitamin D and postmenopausal osteoporosis. Reductions in bone loss at the spine (23) and femoral neck (24,25) were reported, although benefits from additional vitamin D may be seen only at low calcium intakes (26). For fractures, overall incidence was significantly reduced with an annual injection of vitamin D in one study (27); another found no effect of daily vitamin D supplementation on the risk of hip fractures (28).…”
An adequate vitamin D intake is associated with a lower risk of osteoporotic hip fractures in postmenopausal women. Neither milk nor a high-calcium diet appears to reduce risk. Because women commonly consume less than the recommended intake of vitamin D, supplement use or dark fish consumption may be prudent.
“…In comparison with calcium, few clinical trials have focused on vitamin D and postmenopausal osteoporosis. Reductions in bone loss at the spine (23) and femoral neck (24,25) were reported, although benefits from additional vitamin D may be seen only at low calcium intakes (26). For fractures, overall incidence was significantly reduced with an annual injection of vitamin D in one study (27); another found no effect of daily vitamin D supplementation on the risk of hip fractures (28).…”
An adequate vitamin D intake is associated with a lower risk of osteoporotic hip fractures in postmenopausal women. Neither milk nor a high-calcium diet appears to reduce risk. Because women commonly consume less than the recommended intake of vitamin D, supplement use or dark fish consumption may be prudent.
“…Storm et al (7) showed that calcium supplementation (by either calcium carbonate or dietary means) prevented seasonal bone loss in elderly women living in North America. Moreover, Peacock et al (8) showed that a calcium supplement of 750 mg/day prevented loss of bone mineral density (BMD) as well as reduced femoral medullary expansion, secondary hyperparathyroidism, and high bone turnover.…”
The Chinese diet is low in calcium (less than 500 mg/day on average), and previous observational studies have suggested an association between a low calcium intake and risk of hip and vertebral fracture. In this study, we randomly assigned
“…An alternative approach may therefore be required. Presumably owing to its ability to bypass carbon-25 hydroxylation in the liver and its relative affinity for the circulating vitamin D binding protein (DBP), pharmacologic 25-hydroxyvitamin D3 (calcefidiol, 25D3) more rapidly and robustly raises serum 25D levels than parent D3 (12)(13)(14)(15)(16)(17)(18). 25D3 administration also suppresses PTH secretion while D3 does not (18).…”
25D3 increased total and free 25D levels more rapidly than D3, regardless of race/ethnicity. Free and total 25D were similarly associated with change in PTH.
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