Effect of calcium hydroxide alone or in combination with ibuprofen and ciprofloxacin on postoperative pain and periapical prostaglandin E2 level: A randomized clinical study

Karataş, Ertuğrul; Uluköylü, Esra; Albayrak, Mevlüt; Bayır, Yasin

doi:10.1016/j.prostaglandins.2020.106525

Cited by 3 publications

(7 citation statements)

References 29 publications

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“…Microbial invasion stimulates the host's inflammatory response, leading to oedema, vasodilatation, accumulation of immune cells and release of inflammatory mediators (Awawdeh et al, 2002; Bamini et al, 2020; Arslan et al, 2020; Karataş et al, 2020). Over the years, various biomarkers have been suggested to indicate the pathological condition of pulp tissues (Hirsch et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues

et al. 2023

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Aim: To comparatively analyse the levels of culturable bacteria, endotoxins (LPS), tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and substance P in teeth with symptomatic irreversible pulpitis (SIP) and vital normal pulp (VNP) tissues.Methodology: Thirty-two patients were included (20 teeth with SIP and 12 teeth with VNP tissues) in this cross-sectional study. Samples were collected from the full length of the root canals (microbial analysis) and periapical tissues (2 mm beyond the apex for immunological analysis), using sterile absorbent paper points. The levels of culturable bacteria (culture method), endotoxins (LAL Pyrogent 5000), TNF-α, IL-1β and substance P (ELISA) were assessed. The Mann-Whitney test was used for comparisons between the levels of CFU/mL, LPS, TNF-α, IL-1β and substance P in the SIP and VNP groups. The statistical analysis was performed with the significance level set at 5%. Results:Culturable bacteria were recovered from all teeth with SIP. On the other hand, no positive cultures were observed in the VNP tissues group (p > .05). The levels of LPS were approximately four times higher in teeth with SIP than in teeth with VNP tissues (p < .05). Higher levels of TNF-α and substance P were detected in teeth with SIP (p < .05). On the other hand, no difference in the levels of IL-1β was detected between the two groups (p > .05). Conclusion:Teeth with symptomatic irreversible pulpitis present higher levels of culturable bacteria, endotoxins, TNF-α and substance P than those with vital normal pulp tissues. On the other hand, the levels of IL-1β were similar in teeth from both groups suggesting reduced implications of this inflammatory mediator in the early stages of infection.

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Section: Discussionmentioning

confidence: 99%

Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues

et al. 2023

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“…Regarding intracanal medication protocols, the addition of ciprofloxacin or chlorhexidine to calcium hydroxide was shown to be highly effective in lowering PGE2 levels 88,89 . In addition, there are some reports that, in rat pulps and pulpal cells, treatment with mineral trioxide aggregate (MTA) enhance the expression of PGE2 transporters and receptors in odontoblasts, endothelial cells, and nerve fibers, while also inducing the upregulation of COX-2 and PGE2 and activation of NFkB 90,91 .…”

Section: Cox Changes In Pulpal and Periapical Diseasementioning

confidence: 99%

The importance of cyclooxigenase in dentistry

Barrera,

Cepeda,

Parras

2024

Braz.j. of oral sci.

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Aim: Cyclooxygenase enzymes (COX) catalyze the conversion of arachidonic acid to prostaglandins and thromboxanes during pain and inflammation conditions. These enzymes have also been linked to several other conditions and diseases, and hence, in dentistry, it is crucial to identify the processes that increase the levels of these mediators. This paper aims to describe the significance of COX in dental practice through a narrative review. Methods: Articles relating to COX upregulation published in English and Spanish over the last 51 years in databases such as EBSCO, Google Scholar, Science Direct, PubMed, and Web of Science; were analyzed. Results: A total of 115 articles demonstrating the relationship between COX upregulation and multiple conditions and diseases of importance in prosthodontics, periodontics, oral pathology, orthodontics, and endodontics were included. Conclusions: COX upregulation is related to inflammatory and malignant diseases in oral tissues, such as periodontitis, pulpitis, and oral cancer, nevertheless, its expression is advantageous in other fields of study such as orthodontics. Additionally, is well documented that dental materials provoke an undesired increase in COX expression, which could be a significant factor that directly affects pulpal health.

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“…root canal system [1,2]. The periapical lesion represents the localized immune-inflammatory response due to the increase in the number and progression of microorganisms from the contaminated root canals toward the apical and periapical tissues resulting in bone and tooth resorption [3,4]. The periapical inflammatory reaction is composed of a mixed inflammatory infiltrate, characterized by the presence of neutrophils, T and B lymphocytes, plasmocytes, and macrophages, with a higher cellular prevalence depending on the stage of the disease [5,6].…”

Section: Highlights Findingsmentioning

confidence: 99%

“…of endodontic treatment [2,6]. Still, in experimental models of periodontal disease and periapical lesions, the presence of bacteria stimulates the local inflammatory response and the intense production of proteases that degrade the extracellular environment and facilitate the process of bone resorption [3,4]. Currently, calcium hydroxide has been considered the intracanal medication of choice because it has properties such as a) microbial control, b) dissolution of organic debris, c) antiinflammatory power, and d) inhibition of inflammatory resorptions [1][2][3].…”

Section: Highlights Findingsmentioning

confidence: 99%

“…In this regard, a large number of studies have been focused on the development of basic and clinical concepts that guide the endodontic treatment of teeth without pulpal vitality [3]. Pulp necrosis represents the death of the pulp, meaning the cessation of its metabolic processes, with consequent loss of its structure as well as its natural defenses.…”

Section: Introductionmentioning

confidence: 99%

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Periapical repair action and antimicrobial activity through calcium hydroxide-based dressings: a comprehensive review

Campanhola,

Constancio,

Fernandes

et al. 2023

MedNEXT

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Introduction: Endodontic therapy aims at shaping, cleaning, and disinfecting the root canal, being performed by removing all pulp tissue or necrotic remains and microorganisms present in the root canal system. Among the substances proposed as a delay dressing in the endodontic treatment of teeth with chronic periapical reaction, calcium hydroxide stands out. Objective: It was to demonstrate, through a comprehensive review, the main properties of calcium hydroxide, as well as its antibacterial action mechanisms. Methods: After literary search criteria, the selected studies were explored for the construction of the present study, following the PRISMA review rules. The review protocol was based on literary search criteria in major databases such as PubMed, Medline, Bireme, EBSCO, Scielo, and Web of Science. Results and Conclusion: A total of 65 articles were found. Initially, duplication of articles was excluded, resulting in 35 articles. A total of 20 articles were evaluated and 12 were included and developed in this review study. Calcium hydroxide is the most commonly used medication to fight disease-causing bacteria, but when used alone, it may not be able to eliminate these microorganisms. The association of other medications incorporated into calcium hydroxide contributes to positive results with the elimination of more resistant bacteria. Intracanal medications based on calcium hydroxide allow a positive effect on microbial reduction, decreasing the levels of pro-inflammatory cytokines and metalloproteinases.

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Effect of calcium hydroxide alone or in combination with ibuprofen and ciprofloxacin on postoperative pain and periapical prostaglandin E2 level: A randomized clinical study

Cited by 3 publications

References 29 publications

Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues

Quantitative analysis of culturable bacteria, levels of endotoxins, inflammatory mediators and substance P in teeth with symptomatic irreversible pulpitis and in teeth with vital normal pulp tissues

The importance of cyclooxigenase in dentistry

Periapical repair action and antimicrobial activity through calcium hydroxide-based dressings: a comprehensive review

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