Effect of Calcium Extracted from Salt-fermented Anchovy Engraulis japonicus on Osteoporosis in Ovariectomized SD-Rats

Moon, Ji‐Young; Cho, Eun-Ji; Joo, Seong-Je; Park, Jonghoon; Yoon, Sungho; Kim, Man-Do; Kim, Youngman; Hyun, Sook-Kyung; Lim, Eun Seo; Kim, Tea Hoon; Son, Byung-Yil; Kwon, Hyun-Ju; Kim, Byung-Woo; Lee, Eun Woo

doi:10.5657/kfas.2015.0426

Korean Journal of Fisheries and Aquatic Sciences

2015

DOI: 10.5657/kfas.2015.0426

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Effect of Calcium Extracted from Salt-fermented Anchovy Engraulis japonicus on Osteoporosis in Ovariectomized SD-Rats

Ji‐Young Moon¹,

Eun-Ji Cho²,

Seong-Je Joo³

et al.

Abstract: This study examined the effect of calcium (AC) extracted from salt fermented anchovy Engraulis japonicus on osteoporosis in ovariectomized (OVX) SD female rats. After AC treatment for 8 weeks, the body weight of the OVX-AC group decreased, while the weight of the OVX group (control) increased 43.9%. The blood osteocalcin, calcium, and ALP levels were examined as physiological markers for osteoporosis. The concentrations of all markers were elevated in the OVX-AC group compared to the OVX group. Thus, anchovy c… Show more

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2024

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Effects of Gloiopeltis furcata Extract on Osteoclastogenesis and Osteoporosis in Ovariectomized Rats

Kang,

Park,

Jung

et al. 2024

JKFN

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Osteoporosis is an age-dependent metabolic bone disease characterized by reduced bone mass. Postmenopausal women with estrogen deficiency are at high risk of developing osteoporosis. This study examined the effects of Gloiopeltis furcata ethanol extract (GFE) on osteoclastogenesis in vitro and ovariectomy (OVX)-induced osteoporosis in vivo. GFE (10∼250 μg/mL) inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast proliferation and tartrate-resistant acid phosphatase (TRAP) activity. The RANKL-induced protein expression of nuclear factor of activated T cells c1 and TRAP, which are the key transcription factors for osteoclastogenesis, was also decreased by a treatment with GFE. On the other hand, female rats were assigned to five experimental groups: SHAM (sham-operated), OVX-CON (OVX), OVX-GFE20 (OVX＋GFE 20 mg/kg/d), OVX-GFE200 (OVX＋GFE 200 mg/kg/ d), and OVX-E2 (OVX＋estradiol 10 μg/kg/d). After six weeks, an analysis of various bone-related serum parameters showed that the levels of alkaline phosphatase, osteocalcin, TRAP, and RANKL decreased after the administration of GFE. 3D micro-CT analysis showed that the low bone density that developed in the OVX-CON group was reversed in the OVX-GFE20 and OVX-GFE200 groups. H&E and Safranin-O staining revealed less bone destruction in the OVX-GFE groups than in the other groups. Therefore, GFE may serve as a novel therapeutic agent for the treatment of osteoporosis.

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Effects of Gloiopeltis furcata Extract on Osteoclastogenesis and Osteoporosis in Ovariectomized Rats

Kang,

Park,

Jung

et al. 2024

JKFN

View full text Add to dashboard Cite

show abstract

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Effect of Calcium Extracted from Salt-fermented Anchovy Engraulis japonicus on Osteoporosis in Ovariectomized SD-Rats

Cited by 1 publication

References 13 publications

Effects of Gloiopeltis furcata Extract on Osteoclastogenesis and Osteoporosis in Ovariectomized Rats

Effects of Gloiopeltis furcata Extract on Osteoclastogenesis and Osteoporosis in Ovariectomized Rats

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