Effect of Calcitriol and Trifluoperazine on Glucose Stimulated B Cell Function in Healthy Humans

Žofková, I; Stolba, P

doi:10.1055/s-0029-1211008

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…Suboptimal vitamin D (< 30 ng mL )1 ) is highly prevalent in overweight and obese subjects ( ‡ 80%) as noted in this study (Table 3) as well as in others [20,31]. Although the existing interventional studies provide conflicting results [32][33][34][35], raising serum 25OHD has been reported to improve fasting blood glucose concentration and insulin sensitivity in subjects with impaired fasting glucose [36]. Thus, the correction of hypovitaminosis D in overweight and obese subjects could potentially improve glucose metabolism and reduce the incidence of type 2 diabetes.…”

Section: Discussionmentioning

confidence: 83%

Interaction of BMI with vitamin D and insulin sensitivity

Karnchanasorn

Lee

et al. 2011

European Journal of Clinical Investigation

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We observed stronger associations of serum 25OHD with insulin sensitivity in overweight than normal weight subjects, suggesting that overweight subjects with hypovitaminosis D may benefit more from vitamin D replacement than normal weight subjects. Furthermore, the optimal serum 25OHD concentration for insulin sensitivity is about 40 ng mL(-1). As more than 60% of the US population is overweight and hypovitaminosis D is highly prevalent in overweight subjects, hypovitaminosis D has a large population attributable risk for type 2 diabetes.

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Section: Discussionmentioning

confidence: 83%

Interaction of BMI with vitamin D and insulin sensitivity

Karnchanasorn

Lee

et al. 2011

European Journal of Clinical Investigation

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“…On the other hand, other studies did not find any effect of vitamin D supplementation [44,45,46]. Grimnes et al [47] could not find any effect of 6 months of 20,000 IU vitamin D 3 administrated orally twice a week to a healthy Caucasian cohort who had vitamin D levels lower than 40.3 ± 12.8 nmol/l on both insulin sensitivity and secretion.…”

Section: Link Between Vitamin D and Glucose Homeostasis - Evidence Frmentioning

confidence: 94%

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

et al. 2014

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In recent years there has been increasing interest in the non-skeletal effects of vitamin D. It has been suggested that vitamin D deficiency may influence the development of diabetes, cardiovascular dysfunction and autoimmune diseases. This review focuses on the current knowledge of the effects of vitamin D and its deficiency on cardiovascular function, glucose homeostasis and immune function, with a particular focus on children. Although, there is good evidence to show that there is an association between vitamin D deficiency and an abnormality of the above systems, there is little evidence to show that vitamin D supplementation leads to an improvement in function, especially in childhood.

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Section: Serum 25-oh-vitamin D [25(oh)d]mentioning

confidence: 99%

“…As to b-cell function, some studies have shown beneficial effects (6-9), whereas some have not (10)(11)(12)(13). Only two studies used a more sophisticated method for assessment (intravenous glucose tolerance test) (8,10). Regarding insulin sensitivity, a few studies have reported an improvement in insulin sensitivity (13,14), but several did not (8,12,(15)(16)(17)(18)(19).…”

Section: Serum 25-oh-vitamin D [25(oh)d]mentioning

confidence: 99%

No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial

et al. 2016

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OBJECTIVEThere has been conflicting evidence regarding the potential role of vitamin D in glucose homeostasis. This study was designed to investigate the effect of highdose vitamin D3 treatment on b-cell function, insulin sensitivity, and glucose tolerance in subjects with prediabetes or diet-treated type 2 diabetes. RESEARCH DESIGN AND METHODSSubjects (n = 44) were randomized to 30,000 IU vitamin D3 once weekly or placebo for 8 weeks. Hyperglycemic clamp assessed first-phase (0-12 min) and secondphase (12-120 min) insulin response, insulin sensitivity, and disposition index (DI). An oral glucose tolerance test assessed glucose tolerance and glycosylated hemoglobin assessed glycemic control. CONCLUSIONSThis study gives no support for any substantial effect of high-dose vitamin D treatment for 8 weeks in prediabetes or diet-treated type 2 diabetes on b-cell function, insulin sensitivity, or glycemic control.Evidence suggesting that vitamin D has an important role in glucose homeostasis has accumulated during the last three decades. A meta-analysis concluded that observational studies have demonstrated a relatively consistent association between low vitamin D serum levels and prevalence of type 2 diabetes or metabolic syndrome (1). Moreover, cohort studies have shown an inverse association between baseline

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Effect of Calcitriol and Trifluoperazine on Glucose Stimulated B Cell Function in Healthy Humans

Cited by 16 publications

References 11 publications

Interaction of BMI with vitamin D and insulin sensitivity

Interaction of BMI with vitamin D and insulin sensitivity

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial

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