Effect of caffeine on the ventilatory response to inhaled carbon dioxide

Pianosi, Paul; Grondin, Danielle; Desmond, Katherine J.; Coates, Allan L.; Aranda, Jacob V.

doi:10.1016/0034-5687(94)90093-0

Cited by 19 publications

(16 citation statements)

References 15 publications

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“…If they do not alter the characteristics of the peripheral plant, these drugs should decrease P a CO 2 . Indeed, these predictions are consistent with experimental observations (Cummin et al 1990;Pianosi et al 1994).…”

Section: Quantitative Analysis Of Central Controller and Peripheral Psupporting

confidence: 89%

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Integrated characterization of the human chemoreflex system controlling ventilation, using an equilibrium diagram

et al. 2004

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The chemoreflex system controlling ventilation consists of two subsystems, i.e., the central controller (controlling element), and peripheral plant (controlled element). We developed an integral framework to quantitatively characterize individual ventilatory regulation by experimental determination of an equilibrium diagram using a modified metabolic hyperbola and the CO2 response curve. In 13 healthy males, the steady-state arterial CO2 pressure (P(a)CO2) and minute ventilation (V(E)) were measured. To characterize the central controller, we changed fraction of inspired CO2 (0, 3.5, 5 and 6% CO2 in 80% oxygen with nitrogen balance) and measured the P(a)CO2-V(E) relation. To characterize the peripheral plant, we altered V(E) by hyper- or hypoventilation using a visual feedback method, which made it possible to control both tidal volume and breathing frequency, and measured the VE-P(a)CO2 relation. The intersection between the two relationship lines gives the operating point. The relationship between P(a)CO2 and V(E) for the central controller was reasonably linear in each subject (r2 = 0.808-0.995). The peripheral plant approximated a modified metabolic hyperbolic curve (r = 0.962-0.996). The operating points of the system estimated from the two relationship lines were in good agreement with those measured under the closed-loop condition. The gain of the central controller was 1.9 (1.0) l min(-1) mmHg(-1) and that of the peripheral plant was 3.0 (0.5) mmHg l(-1) min(-1). The total loop gain, the product of the two gains, was 5.3 (2.5). We conclude that human ventilatory regulation by the respiratory chemoreflex system can be quantitatively characterized using an equilibrium diagram. This framework should be useful for understanding the mechanisms responsible for abnormal ventilation under various pathophysiological conditions.

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Section: Quantitative Analysis Of Central Controller and Peripheral Psupporting

confidence: 89%

“…Each FICO 2 trial ran for 15 min at approximately 10-15 min intervals. This duration is long enough to permit CO 2 to reach its new steady-state value at the central chemoreceptors (Honda et al 1983;Poon and Greene 1985;Pianosi et al 1994;Teppema et al 2000). During the interval periods, the subjects inspired room air.…”

Section: Methodsmentioning

confidence: 99%

Integrated characterization of the human chemoreflex system controlling ventilation, using an equilibrium diagram

et al. 2004

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“…In addition, Pianosi et al (1994) found that the slope of the line defined by the ratio VE/partial pressure of carbon dioxide (millimeters of mercury) was duplicated by caffeine in adult humans. Several recent studies (Wang et al, 2005;Vandam et al, 2008) have shown that adenosine decreases respiratory rhythmogenesis by activating A 1 and A 2 receptors at different brainstem nuclei; therefore, the answer to the first question may reside in the A 1 and A 2 receptor antagonism by caffeine, which would result in the observed increase in VE.…”

Section: Discussionmentioning

confidence: 99%

Chronic Caffeine Intake in Adult Rat Inhibits Carotid Body Sensitization Produced by Chronic Sustained Hypoxia but Maintains Intact Chemoreflex Output

et al. 2012

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Sustained hypoxia produces a carotid body (CB) sensitization, known as acclimatization, which leads to an increase in carotid sinus nerve (CSN) activity and ensuing hyperventilation greater than expected from the prevailing partial pressure of oxygen. Whether sustained hypoxia is physiological (high altitude) or pathological (lung disease), acclimatization has a homeostatic implication because it tends to minimize hypoxia. Caffeine, the most commonly ingested psychoactive drug and a nonselective adenosine receptor antagonist, alters CB function and ventilatory responses when administered acutely. Our aim was to investigate the effect of chronic caffeine intake on CB function and acclimatization using four groups of rats: normoxic, caffeine-treated normoxic, chronically hypoxic (12% O 2 , 15 days), and caffeine-treated chronically hypoxic rats. Caffeine was administered in drinking water (1 mg/ml). Caffeine ameliorated ventilatory responses to acute hypoxia in normoxic animals without altering the output of the CB (CSN neural activity). Caffeine-treated chronically hypoxic rats exhibited a decrease in the CSN response to acute hypoxia tests but maintained ventilation compared with chronically hypoxic animals. The findings related to CSN neural activity combined with the ventilatory responses indicate that caffeine alters central integration of the CB input to increase the gain of the chemoreflex and that caffeine abolishes CB acclimatization. The putative mechanisms involved in sensitization and its loss were investigated: expression of adenosine receptors in CB (A 2B ) was downregulated and that in petrosal ganglion (A 2A ) was up-regulated in caffeine-treated chronically hypoxic rats; both adenosine and dopamine release from CB chemoreceptor cells was increased in chronic hypoxia and in caffeine-treated chronic hypoxia groups.

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“…Additionally, as caffeine and rolipram increased hypercapnic ventilatory response [13,31], restoration of the central chemosensitivity may elevate the activity of the whole respiratory network and indirectly contribute to their ameliorative effect. However, we did not investigate the effects of both drugs on chemosensitivity.…”

Section: Apneustic Discharges Of the Phrenic Nerve Were Recovered By mentioning

confidence: 99%

Blockade of phosphodiesterase 4 reverses morphine-induced ventilatory disturbance without loss of analgesia

2015

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Effect of caffeine on the ventilatory response to inhaled carbon dioxide

Cited by 19 publications

References 15 publications

Integrated characterization of the human chemoreflex system controlling ventilation, using an equilibrium diagram

Integrated characterization of the human chemoreflex system controlling ventilation, using an equilibrium diagram

Chronic Caffeine Intake in Adult Rat Inhibits Carotid Body Sensitization Produced by Chronic Sustained Hypoxia but Maintains Intact Chemoreflex Output

Blockade of phosphodiesterase 4 reverses morphine-induced ventilatory disturbance without loss of analgesia

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