Abstract:A multicenter, double-blind, randomized study was conducted to assess the effect of caffeine on regadenoson stress myocardial perfusion imaging (MPI). Subjects with a high likelihood of coronary artery disease underwent a rest single-photon emission computed tomography MPI on day 1 (MPI-1) and a stress MPI with regadenoson on day 3 (MPI-2). Individuals with ≥1 segment with a reversible defect received double-blind caffeine tablets (200 or 400 mg) or placebo 90 min before a repeat regadenoson stress MPI (MPI-3)… Show more
“…64 Regadenoson-induced hyperemic myocardial blood flow measured by PET was not affected by caffeine ingestion, 65 but reversible defects on SPECT myocardial perfusion imaging were smaller with caffeine consumption. 66 Patients should abstain from caffeinated products for at least 12 hours, which allows for selection of any of the three vasodilator stressors.…”
Section: Caffeine and Coronary Vasodilatorsmentioning
“…64 Regadenoson-induced hyperemic myocardial blood flow measured by PET was not affected by caffeine ingestion, 65 but reversible defects on SPECT myocardial perfusion imaging were smaller with caffeine consumption. 66 Patients should abstain from caffeinated products for at least 12 hours, which allows for selection of any of the three vasodilator stressors.…”
Section: Caffeine and Coronary Vasodilatorsmentioning
“…Data regarding caffeine use and regadenoson stress testing are however limited. Tejani et al [18] conducted a multicenter, double-blind, randomized study to assess the effect of caffeine on regadenoson stress myocardial perfusion imaging (MPI). Subjects with a high likelihood of CAD underwent a rest SPECT MPI on day 1 (MPI-1) and a stress MPI with regadenoson on day 3 (MPI-2).…”
Section: Effect Of Caffeine On Spect Myocardial Perfusion During Regamentioning
“…Potential probability curves estimating the impact of caffeine ingestion on vasodilation perfusion SPECT imaging from three papers cited by the discussants. 11,13,14 The height of the curve is a reflection of the sample size with the peak corresponding to the mean probability estimate of the impact of caffeine on SPECT clinical imaging, and the width reflecting the confidence interval of the prediction. Each curve is cumulative from the previous such that the final curve includes probability estimates from that study plus the estimate of the impact of the two prior studies combined.…”
Section: Frequentist Vs Bayesian Statisticsmentioning
confidence: 99%
“…A hypothetical graphic of that approach is shown in Figure 1. 11,13,14 Bayesian analysis places the accumulated data in perspective with a final estimate of the impact of caffeine on MBF with a confidence interval of that estimate. This could be done with the studies cited in the arguments for the impact of caffeine ingestion prior to vasodilation stress.…”
Section: Frequentist Vs Bayesian Statisticsmentioning
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.