Effect of caffeine on rat offspring from treated dams

Aeschbacher, H.U.; Milon, H.; Foot, A. S.; Würzner, H.P.

doi:10.1016/0378-4274(80)90087-9

Cited by 27 publications

(15 citation statements)

References 10 publications

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“…However, although caffeine caused weight modifications, only more detailed studies can conclude if the alterations were of metabolic origin (Barker, 2000;Silveira, 2004), or due to congenital metabolic alterations exclusively in the offspring. The findings of weight difference between the groups, corroborate other studies available in the literature (Soyka, 1979;Aeschbacher et al, 1980;Evereklioglu et al, 2003).…”

Section: Discussionsupporting

confidence: 90%

Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine

Silva

Alexandre

Nascimento

et al. 2009

Braz. J. Pharm. Sci.

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The influence of caffeine, administered to rats, on the somatic and sensory-motor development of the offspring was investigated. Female Wistar rats were divided into a control group and a treated group and received drinking water and a 0.1% solution of caffeine orally, respectively. The offspring, also divided into a control group and a treated group, received daily monitoring until the 20 th day of life to verify alterations in somatic neural development. The offspring of the treated group had reduced weight on the day of birth and on the 1 st , 5 th , 15 th and 20 th days of life; shorter snout-anus length (evaluation done daily); shorter snout-tail length on the day of birth and on the 1 st , 5 th and 10 th days of life, and signs of retardation of somatic and sensory-motor maturation. These results allowed the conclusion that administration of caffeine to rats affects somatic and sensory-motor development of offspring.Uniterms: Caffeine/effects. Postnatal development. Central nervous system/stimulants. Estudou-se a influência da cafeína, administrada a ratos, no desenvolvimento somático e sensorial-motor da prole. Ratos Wistar fêmeas foram divididos em grupo controle e grupo tratado e receberam água e solução de cafeína a 0,1%, respectivamente. A prole, também dividida em grupo controle e grupo tratado, foi monitorada diariamente até o 20º. dia de vida para se observar as alterações no desenvolvimento somático neural. O grupo tratado apresentou peso reduzido no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida; comprimento focinho-ânus mais curto (avaliação efetuada diariamente); comprimento focinho-cauda mais curto no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida e sinais de retardamento da maturação somática e sensorial-motora. Esses resultados permitem que se conclua que a administração da cafeína a ratos afeta o desenvolvimento somático e sensorial-motor da prole.Unitermos: Cafeína/efeitos. Desenvolvimento pós-natal. Sistema Nervoso Central/estimulantes.

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Section: Discussionsupporting

confidence: 90%

Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine

Silva

Alexandre

Nascimento

et al. 2009

Braz. J. Pharm. Sci.

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“…In view of the fact that dam's milk contains only about 2% of the caffeine received by the nursing mothers [2], the greater effect on the femur than on the mandible suggests that this dosage of caffeine ingested during the critical period of endochondral bone formation may have profound and lasting effects, which are currently unknown. The softer femur, as shown by the microhardness that in the caffeine group, could have certain implications with respect to bone fracture, a problem among the elderly in our society.…”

Section: Discussionmentioning

confidence: 99%

Effects of caffeine intake during gestation and lactation on bones of young growing rats

1990

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The objective of this study was to evaluate the extended effect of caffeine intake received during gestation and lactation on the mandible and femur of rats. Timed-pregnant dams were divided into two groups. Dams of group 1 were fed a 20% protein diet throughout the experimental period from day 9 of gestation. Dams of group 2 were also fed a 20% protein diet, supplemented with caffeine (lmg/100 g of body weight). Upon delivery, 8 pups were assigned to each dam, and the dams were continued on their respective diets. At weaning (day 22 postnatally), only male rats were selected. Pups of both groups were fed a 20% protein diet without caffeine. At day 56 postnatally the rats were killed. Mandibles and femurs were removed and the following parameters analyzed: weight, physical dimension, volume, and Knoop microhardness. Caffeine intake during gestation and lactation resulted in an impairment of femur growth and development and to a lesser extent mandibular growth and development. The early effects of caffeine in the maternal diet were lasting, as noted by the lack of recovery of the offspring even after changing to a caffeine-free diet for an extended time after weaning.

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“…The caffeine-supplemented group re ceived caffeine in utero since caffeine and its metabolites freely pass into the embryo and attain concentration slightly below those of maternal plasma [23], Suckling pups received caffeine solely through the dam's milk [24] which is estimated to be about 2% of that received by their nursing mothers [1], but only up to around day 15. Then, from this time until weaning at day 22, pups begin to nibble the maternal diet (which contained caffeine) so they received caffeine from two sources.…”

Section: Discussionmentioning

confidence: 99%

Chronic Caffeine Intake by Rat Dams during Gestation and Lactation Affects Various Parts of the Neonatal Brain

Nakamoto¹,

Hartman²,

Miller³

et al. 1986

Neonatology

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Timed-pregnant rats were randomly divided into 2 groups on day 13 of gestation. Group 1 received a 20% protein diet. Group 2 was pair-fed to group 1 with a 20% protein diet containing caffeine (1 mg/l00 g body weight). At parturition, the dams of each group were continued on their respective diets until day 22 postpartum. At the time of weaning (day 22), only male rats were continued in the study. At this time, rats from both groups were fed the control diet containing 20% protein. On day 57 and 58, rats were killed, the brains divided into six areas, and DNA, RNA and protein contents were measured. In certain areas of the brain, weight, cholesterol, DNA, RNA and protein contents were different even long after returning to the caffeine-free control diet. The present study demonstrates that even if a relatively small amount of caffeine is taken during gestation and lactation, a time during which the growth rate is greater than in any other period of life, certain areas of the brain may be affected. These findings suggest that future central nervous system impairment may be expressed later in life in these offspring.

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Effect of caffeine on rat offspring from treated dams

Cited by 27 publications

References 10 publications

Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine

Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine

Effects of caffeine intake during gestation and lactation on bones of young growing rats

Chronic Caffeine Intake by Rat Dams during Gestation and Lactation Affects Various Parts of the Neonatal Brain

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