“…Alone, caffeine at millimolar concentrations effects cell cycle traverse by prolonging cell transit through GI phase (Burk 1968, O'Neill979, Iliakis & Nusse 1983, induces mutations and chromosomal aberrations (Kihlman 1977), inhibits enzyme systems involved in DNA replication and repair (Tolmach Jones & Busse 1977, Solberg et al 1978, Nolan & Kidder 1979, Selby & Sancar 1990) and causes extensive chromatin condensation (Borodina et al 1979, Musk et af. Alone, caffeine at millimolar concentrations effects cell cycle traverse by prolonging cell transit through GI phase (Burk 1968, O'Neill979, Iliakis & Nusse 1983, induces mutations and chromosomal aberrations (Kihlman 1977), inhibits enzyme systems involved in DNA replication and repair (Tolmach Jones & Busse 1977, Solberg et al 1978, Nolan & Kidder 1979, Selby & Sancar 1990) and causes extensive chromatin condensation (Borodina et al 1979, Musk et af.…”