Effect of caffeine and adenosine receptor ligands on the expression of spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)

Germé, Katuschia; Faure, J; Koning, Estelle; Nehlig, Astrid

doi:10.1016/j.eplepsyres.2014.11.022

Cited by 17 publications

(18 citation statements)

References 44 publications

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“…In a rat model of genetic absence epilepsy, the number and duration of spike-and-wave discharges (SWDs) on intracranial EEG recordings were dose-dependently reduced after a single medium dose of caffeine, compared to the baseline. This study found no effect of a more chronic exposure to caffeine [52]. A more recent study also showed a decrease in SWD's after the administration of caffeine, linked to an increase of cytokine levels (IL-6 and NFkB) in the thalamus [53].…”

Section: Caffeine Exposure In Adult Rodentscontrasting

confidence: 57%

“…In animal studies, caffeine interacted with some ASMs, particularly topiramate. Single-high doses of caffeine seem more likely to trigger seizures than repeated low doses of caffeine, suggesting the development of tolerance to A1-and A2A-receptor blockade by caffeine [43,46,47,52,83,87,88].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies show conflicting results, which may have been produced by the use of different models pertaining to different epilepsy types [40,42,52,68,88], different ways of inducing seizures [39,58], different methods for caffeine administration, and different doses of caffeine or chemical proconvulsants [50-52, 68, 88]. Some sample sizes are small, limiting their reliability [38,39].…”

Section: Discussionmentioning

confidence: 99%

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The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

Bauer

Sander

2019

Curr Neurol Neurosci Rep

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Purpose of review: Caffeine is the most widely consumed central nervous stimulant. For people with epilepsy, it is often unclear whether drinking coffee carries a risk of triggering seizures. Recent findings: The relationship between caffeine, seizures, epilepsy and anti-seizure drugs is not fully understood. Clinical studies are scarce. In animal models, caffeine can increase seizure susceptibility but can also protect from seizures. Effects seem dose-dependent and, influenced but the duration of intake and the developmental stage at which caffeine exposure started. Caffeine lowers the efficacy of several anti-seizure medication, especially topiramate. Summary: It is unclear how these findings, mainly from animal studies can be translated to the clinical condition. At present, there is no evidence to advice people with epilepsy against the use or overuse of caffeine. Until clinical studies suggest otherwise, caffeine intake should be considered as a factor in achieving and maintaining seizure control in epilepsy.

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Section: Caffeine Exposure In Adult Rodentscontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

Bauer

Sander

2019

Curr Neurol Neurosci Rep

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“…We think that decreased cytokine concentrations might have prolonged the seizure latency. It was shown that acute exposure to adenosine and caffeine decreases the number of spikeand-wave discharges (SWDs) in genetically epileptic rats [23,24] . An interesting study, which evaluated the effects of caffeine on PTZ-induced generalized tonic-clonic seizures, reported that acute caffeine administration does not affect the latency to first clonic seizure, the latency to generalized tonic-clonic seizure and the duration of generalized tonic-clonic seizure [11] .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model

Dede¹,

Karadenizli²,

Özsoy

et al. 2017

Neuroimmunomodulation

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Objective: It has been suggested that the adenosinergic system and cytokines play a role in the pathogenesis of epilepsy. Although the role of the adenosinergic system in the modulation of seizure activity is well known, the mechanism of this modulation needs to be described in detail. We performed this study to determine the contribution of the proinflammatory cytokines to the generalized seizure activity during adenosine and caffeine treatment. Methods: We induced generalized tonic-clonic seizures with the administration of 60 mg/kg pentylenetetrazole (PTZ) in male Wistar Albino rats. Adenosine (500 mg/kg) or caffeine (5 mg/kg) was administered before PTZ injection. We monitored seizure activity and then determined the TNF-α, IL-1β, and IL-6 levels in the cortical and thalamic brain regions of rats by ELISA. Results: Adenosine pretreatment significantly extended seizure latency (p < 0.05), but did not affect seizure duration and entry time to stage 4 seizure. Caffeine pretreatment did not change seizure latency and seizure duration. PTZ treatment did not change brain cytokine levels significantly (p > 0.05) compared to the control group. Whereas adenosine pretreatment decreased brain TNF-α, IL-1β, and IL-6 levels significantly (p < 0.05), caffeine pretreatment reduced brain cytokine levels slightly but nonsignificantly (p > 0.05). Conclusion: Our results show that there is a clear relation between adenosinergic system and brain tissue cytokine levels. Our findings indicated that TNF-α, IL-1β, and IL-6 participate in the pathogenesis of generalized seizures, and the inhibition of TNF-α, IL-1β, and IL-6 with adenosinergic modulation may decrease seizure severity.

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“…Furthermore, the relationship between caffeine consumption and seizures has been studied throughout the years, in models of absence epilepsy and convulsive seizures, with different effects. [126][127][128] Importantly, studies have shown the potential of adenosine as a modulator of epilepsy and seizures, when it is locally delivered in the affected brain regions, using a synthetic polymer or osmotic minipumps. [129][130][131] At present, stem cell-based therapeutic options for epilepsy are being studied.…”

Section: Epilepsymentioning

confidence: 99%

Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

Mateus

Ribeiro

Alonso-Gomes

et al. 2019

Journal of Caffeine and Adenosine Research

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The processes of neural genesis, namely neurogenesis, astrogliogenesis, and oligodendrogenesis, that is, the formation of new neurons, astrocytes, and oligodendrocytes start with embryonic development. Of importance, it continues throughout adulthood, not only in the neurogenic niches where neural stem cells (NSCs) are present, but also from glial precursor cells in the brain parenchyma. Therefore, NSCs can be considered a potential therapeutic option in conditions of neural loss and tissue degeneration, as in neurodegenerative diseases. Specifically, stem cell therapy represents a personalized, localized, and probably fruitful alternative in patient care, and is the subject of ongoing research. Nevertheless, many mechanisms of this regenerative therapy remain elusive: if transplantation is required, not only is it necessary to successfully deliver these NSCs to the brain, but they also need to survive, proliferate, and replace the lost neural cells. In line with this, finding ways to manipulate the endogenous sources of NSCs is also very appealing. In particular, adenosine and caffeine (a nonselective antagonist of adenosine receptors), widely studied modulators of neuronal activity, have emerged as potential targets of neurogenesis and oligodendrogenesis. In this article, we review the present concepts on the role of adenosine in embryonic and postnatal neural cell genesis, together with its relevance in the context of brain regeneration.

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Effect of caffeine and adenosine receptor ligands on the expression of spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)

Cited by 17 publications

References 44 publications

The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model

Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

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