Effect of cadmium on thyroid function in sheep

Badiei, Khalil; Nikghadam, Pegah; Mostaghni, K.

doi:10.1007/s00580-008-0785-4

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…This may be due to thrombocytopenia and thrombocytosis after chronic lead intoxication (Sudakova et al, 1983;Mugahi et al, 2003;Abdulkareem, 2010); while the insignificant increase in the white blood cell may be due to lead induced inflammation (Yagminas et al, 1990, Alwaleedi, 2015.Significant increase in ALT and AST which are biomarkers for liver toxicity was observed in this study (P<0.05), might be due to increased cell membrane permeability, increased cellular basal metabolic rate or cell membrane damage of hepatocytes caused by lead acetate. These results agree with previous studies reported an elevation in AST and ALT levels after treatment with lead due to acute hepatitis, jaundice, and liver cirrhosis in mice, human and rat (Mehta et al, 2002;Patil et al, 2007;Shalan et al, 2005, Alwaleedi, 2015, also in sheep (Badiei et al, 2009). The significant decrease in albumin at the reparatory phase E3 J. Med.…”

Section: Discussionsupporting

confidence: 92%

Untitled

2016

EJMR

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Lead contamination through wound could either be environmental and or systemic sources that impair wound healing in animals. The haematological, biochemical changes including thewound healing effects of topical lead poisoning were therefore investigated using ten adult West African dwarf (WAD) goats, randomly divided into two groups of five animals each. The first group served as the control and the second group was treated with lead chloride solution. Wound contraction was compared between the two groups, haematology and serum biochemistry were analysed at each stage of the healing process. The results revealed a delay in wound contraction in the lead treated group. Erythrocyte sedimentation rate, haemoglobin concentration, packed cell volume, albumin, neutrophil count in the lead treated group decreased significantly (P<0.05).Heart rate and temperature increased significantly (P<0.05, P<0.01) in the treated group. This study concluded that epidermal lead exposure impaired wound healing.

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Section: Discussionsupporting

confidence: 92%

Untitled

2016

EJMR

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“…Similarly, Meeker et al [ 17 ] demonstrated an inverse association between urinary concentration of CPF metabolites, 3,5,6-trichloro-2-pyridinol and T 4 level and a positive association with TSH. In the same vein, hypothyroidism has been associated with Pb [ 45 , 46 ] poisoning. Perhaps the reason why the coadministration of CPF and Pb did not result in significant alteration in thyroid hormone concentrations may be due to the very low doses of the two chemicals used.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats

Ambali

Orieji

Abubakar

et al. 2011

Journal of Thyroid Research

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The present study evaluated the ameliorative effect of vitamin C on alteration in thyroid hormones induced by low-dose subchronic coadministration of chlorpyrifos (CPF) and lead (Pb). Forty Wistar rats were divided into 4 groups of 10 animals each. Groups I and II were administered soya oil (2 mL/kg) and vitamin C (100 mg/kg), respectively. Group III was coadministered CPF (4.25 mg/kg ~1/20th LD50) and Pb (250 mg/kg ~1/20th LD50), respectively. Group IV was pretreated with vitamin C (100 mg/kg) and then coadministered with CPF (4.25 mg/kg) and Pb (250 mg/kg), 30 min later. The regimens were administered by gavage for a period of 9 weeks. The marginal decrease in serum triiodothyronine and thyroxine and the significant increase in the concentrations of thyroid stimulating hormone and malonaldehyde in the group coadministered with CPF and Pb were ameliorated by vitamin C partly due to its antioxidant properties.

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“…The observed hypogonadism may be a consequence of hypothyroidism where it is well known that hypothyroidism is associated with a decrease in male sex hormones, abnormal spermatogenesis, and retardation of Sertoli cell differentiation (Mohamed and Gawad, 2017). T3 The observed thyroid dysfunction may be related to structural damage of thyroid follicular cells due to accumulation of Pb in the thyroid gland (Baoliei et al, 2009). The observed increase in serum TSH level is likely a response to decreases serum T4 and T3 level.…”

Section: Effect Of Apg On In Ammation Response In Testis and Thyroid Gland Of Rats Treated With Lead Acetatementioning

confidence: 97%

Apigenin Ameliorates Lead Acetate induced Hyperlipidemia, Hypothyroidism and Hypogonadism in Male Rats

Algefare

Sedky

Alfwuaires

et al. 2021

Preprint

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Lead (Pb) is an environmental pollutant and has detrimental effects on human health. Apigenin (APG) is a flavonoid that have antioxidant, anti-inflammatory, antiallergic, and cardioprotective effects and is presented as treatment of some diseases. The aim of the present study was to evaluate the probable protective effect of APG against Pb-induced toxicity in rats. Adult male rats were given either Pb (as lead acetate; 20 mg/kg) alone or in combination with APG (20 mg/kg) daily for 4 weeks by intraperitoneally injection (i.p). At the end of the experimental period, Pb accumulation, lipid profile, thyroid, and testicular function alterations were assessed. In addition, histopathological changes in the testis were assessed.Results revealed that Pb treatment significantly increased Pb concentrations in blood, thyroid gland, and in testis of rats. Further, the blood levels of hormones related to thyroid gland and testis were altered in Pb-treated rats. In parallel, low sperm count and sperm motility, increased sperm abnormalities, and marked pathological changes in testis were observed. On the contrary, the treatment with both Pb and APG recorded amelioration of the deleterious effects of Pb, involving attenuation of changes in lipid profile, thyroidal and testicular hormonal levels, sperm parameters and pathological changes in Pb treated rat’s testis. In conclusion, it appears that dietary APG can ameliorate lead acetate induced hyperlipidemia, hypothyroidism and hypogonadism in male rats.

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Effect of cadmium on thyroid function in sheep

Cited by 13 publications

References 19 publications

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Untitled

Ameliorative Effect of Vitamin C on Alterations in Thyroid Hormones Concentrations Induced by Subchronic Coadministration of Chlorpyrifos and Lead in Wistar Rats

Apigenin Ameliorates Lead Acetate induced Hyperlipidemia, Hypothyroidism and Hypogonadism in Male Rats

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