Effect of Butyric Acid Supplementation on Serum and Renal Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

Kumar, Anbarasu; Chougala, Mallikarjun; Nandini, C.; Salimath, Paramahans V.

doi:10.1111/j.1745-4514.2009.00284.x

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…In vivo data indicate that orally administered sodium butyrate (SB) promotes the growth performance of weaning pigs [15], improves the intestinal health of humans [16], and delays the onset of diabetes in rats [17]. SB supplementation has a similar effect to wheat bran and guar gum on antioxidant property in diabetic rats [18]. Other studies have shown that diets supplemented with single SCFA or SCFA mixture may have a similar role to sugar-beet fiber in lowering the plasma cholesterol of rats [19] and alleviating rat colitis [20].…”

Section: Introductionmentioning

confidence: 99%

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

et al. 2014

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In this study, we evaluated the effect of replacing dietary fiber with sodium butyrate on reproductive performance and antioxidant defense in a high fat diet during pregnancy by using a rat model. Eighty virgin female Sprague Dawley rats were fed one of four diets—(1) control diet (C group), (2) high fat + high fiber diet (HF group), (3) high-fat +5% sodium butyrate diet (SB group), and (4) HF diet + α-cyano-4-hydroxy cinnamic acid (CHC group)—intraperitoneally on days 8, 10, 12, 14, and 16 of gestation. SB and dietary fiber had similar effects on improving fetal number and reducing the abortion rate; however, the anti-oxidant capacity of maternal serum, placenta, and fetus was superior in the HF group than in the SB group. In comparison, CHC injection decreased reproductive performance and antioxidant defense. Both dietary fiber (DF) and SB supplementation had a major but different effect on the expression of anti-oxidant related genes and nutrient transporters genes. In summary, our data indicate that SB and DF showed similar effect on reproductive performance, but SB cannot completely replace the DF towards with respect to redox regulation in high-fat diet; and SB might influence offspring metabolism and health differently to DF.

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Section: Introductionmentioning

confidence: 99%

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

et al. 2014

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“…The role of fermentation product of dietary fibres in the form of short chain fatty acids such as acetate, propionate and butyrate is also to be considered in the amelioration of diabetic status 39 . Some earlier studies already showed beneficial effects of butyric acid during diabetes 40 .…”

Section: Discussionmentioning

confidence: 93%

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2015

IJPSR

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This study investigated the antidiabetic activity of the aqueous extract of the leaves of Ageratum conyzoides. Streptozotocin induced hyperglycemia male adult albino rats were used to study the antidiabetic effect of Ageratum conyzoides aqueous extract (at doses of 100, 200 and 300 mg/kg respectively). The diabetic rats were housed in metabolic cages, for the whole period of the experiment. Body weight was evaluated at the beginning of the experiment and on days 7, 14, and 21 afterward. Water intake, food intake and urine excretion volume were also estimated. At the end of the experiment the rats were sacrificed and serum insulin concentration, total serum proteins and hepatic glycogen content were estimated. Lipid profile (total cholesterol (TC), High density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides (TG)) were also assessed. The results showed significant effect of stimulating body weight growth at the doses of 200, 300 mg/kg. The effect of the extract on the food, water intake and water excretion showed a significant decrease in the 200 and 300 mg/kg extract treated groups. In treated rats, both doses (200 and 300 mg/kg) induced a significant reduction in serum glucose and the Area Under the glucose Curve, with concomitant increases in serum insulin and protein levels. Furthermore, A. conyzoides treatment improve lipid profile by increase HDL and reducing triglycerides and LDL at 200 mg/kg. The present study clearly indicates that Ageratum conyzoidesaqueous extract leaves exhibited significant antidiabetic activity and supports its uses in traditional medicine.

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“…The most abundant compounds in GFM were PA (30.00%), methyl linoleate (34.10%), and LA (34.66%), accounting for about 98.76% of the GFM. Table shows 4 biologically active molecules (PA, HA, methyl linoleate, and LA), which may have varying antioxidant or alcohol metabolic activities (Beeharry and others ; Kumar and others ; Kwon and others ). The consequences of ethanol metabolism may result in the formation of harmful components, such as highly reactive oxygen‐containing molecules (ROS) that can damage liver tissues (Koop ).…”

Section: Resultsmentioning

confidence: 99%

Ginsenoside‐Free Molecules from Steam‐Dried Ginseng Berry Promote Ethanol Metabolism: An Alternative Choice for an Alcohol Hangover

Lee

Kim

Lee

et al. 2014

Journal of Food Science

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Ethanol metabolism produces harmful compounds that contribute to liver damage and cause an alcohol hangover. The intermediate metabolite acetaldehyde is responsible for alcohol hangover and CYP2E1-induced reactive oxygen species damage liver tissues. In this study, we examined whether ginsenoside-free molecules (GFMs) from steam-dried ginseng berries promote ethanol metabolism and scavenge free radicals by stimulating primary enzymes (alcohol dehydrogenase, aldehyde dehydrogenase, CYP2E1, and catalase) and antioxidant effects using in vitro and in vivo models. The results revealed that GFM effectively scavenged 2,2-diphenyl-1-picrylhydrazyl hydrate radicals and hydroxyl radicals. Notably, GFM significantly enhanced the expression of primary enzymes within 2 h in HepG2 cells. GFM clearly removed the consumed ethanol and significantly reduced the level of acetaldehyde as well as enhancement of primary gene expression in BALB/c mice. Moreover, GFM successfully protected HepG2 cells from ethanol attack. Of the major components identified in GFM, it was believed that linoleic acid was the most active ingredient. Based on these findings, we conclude that GFM holds promise for use as a new candidate for ethanol metabolism and as an antihangover agent.

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Effect of Butyric Acid Supplementation on Serum and Renal Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

Cited by 18 publications

References 41 publications

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

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Ginsenoside‐Free Molecules from Steam‐Dried Ginseng Berry Promote Ethanol Metabolism: An Alternative Choice for an Alcohol Hangover

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