Effect of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on rat erythrocytes

Jayalakshmi, C. P.; Sharma, Jayashri Devi

doi:10.1016/s0013-9351(86)80185-2

Cited by 25 publications

(9 citation statements)

References 13 publications

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“…These antioxidants are two of the most common antioxidant compounds used in the European Union (EU) for food, cosmetic and pharmaceutical applications. However, long-term exposure to high doses of BHT could have negative effects on human health as well as on the environment [54]. Hazelnut and walnut lignins presented lower antioxidant power than ascorbic acid, while the DPPH and ABTS free radical scavenging activity were found quite similar to BHT, concluding that isolated lignins could be a promising bioactive compound to promote the replacement of BHT in several fields.…”

Section: Total Phenolic Content (Tpc) and Antioxidant Properties Of Lmentioning

confidence: 96%

Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities

2020

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The growing concern about the environmental impact and human health risk related to the excessive use of synthetic ingredients in cosmetics and topical formulations calls for the exploration of safe and sustainable natural alternatives. Lignin-rich lignocellulosic industrial wastes such as hazelnut and walnut shells were used as a lignin polymer source. Agro-derived lignins were evaluated as a potential natural active ingredient for health care products. Aside from the structural characteristics of isolated lignins, which were identified by GPC, Py-GC–MS, and 2D HSQC NMR techniques, functional properties such as antioxidant power and UV absorption ability were investigated. The SPF values found for creams containing 5% of hazelnut and walnut lignin content were 6.9 and 4.5, respectively. Additionally, both lignin types presented appropriate protection against UVA radiation, highly interesting property to block the full ultraviolet spectrum. The biological activity of isolated lignins assessed at different concentrations (0.01–1 mg/mL) and different times (24, 48, and 72 h) on murine fibroblast cell line 3T3 suggested their suitability for cosmetic applications.

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Section: Total Phenolic Content (Tpc) and Antioxidant Properties Of Lmentioning

confidence: 96%

Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities

2020

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“…Free radicals can also cause lipid peroxidation in foods that leads to their deterioration. Synthetic antioxidants, such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), are suspected of carcinogenicity and of hormonal perturbation [6, 7]. Therefore, the search for natural antioxidants has been greatly intensified in recent years.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial, Antioxidant Activities and Phytochemical Analysis of Canarium patentinervium Miq. from Malaysia

Rajagopal

Khoo

Wiart

2011

Biotechnology Research International

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Six different extracts of Canarium patentinervium Miq. (Burseraceae) leaves and barks were screened for their phytochemical composition, and antimicrobial and free radical scavenging activities. Among the different extracts tested, the ethanol extract of leaves showed significant antimicrobial and radical scavenging activities. The most susceptible micro-organisms were found to be Gram-positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus or MRSA) and Gram-negative bacteria (Pseudomonas aeruginosa). Phytochemical analysis of the extracts revealed that the antimicrobial and the radical scavenging activities are mainly due to the presence of tannins and flavonoids. The results obtained suggest that Canarium patentinervium Miq. could be exploited in the management of various infectious diseases.

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“…The potential toxicity of these synthetic antioxidant compounds, such as BHT and BHA [3,4], combined with the new movement towards organic foods, "slow food", and functional foods, have prompted manufacturers to use natural compounds in place of synthetic derivatives. However, even though this substitution is now technologically accessible, the economic aspect has prevented it from becoming a widespread practice.…”

Section: Introductionmentioning

confidence: 99%

Synergism on antioxidant activity between natural compounds optimized by response surface methodology

Capitani

Carvalho

Botelho

et al. 2009

Euro J Lipid Sci & Tech

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Despite the increase in the use of natural compounds in place of synthetic derivatives as antioxidants in food products, the extent of this substitution is limited by cost constraints. Thus, the objective of this study was to explore the synergism on the antioxidant activity of natural compounds, for further application in food products. Three hydrosoluble compounds (x 1 = caffeic acid, x 2 = carnosic acid, and x 3 = glutathione) and three liposoluble compounds (x 1 = quercetin, x 2 = rutin, and x 3 = genistein) were mixed according to a "centroid simplex design". The antioxidant activity of the mixtures was analyzed by the ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) methodologies, and activity was also evaluated in an oxidized mixed micelle prepared with linoleic acid (LAOX). Cubic polynomial models with predictive capacity were obtained when the mixtures were submitted to the LAOX methodology (ŷ = 0

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Effect of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on rat erythrocytes

Cited by 25 publications

References 13 publications

Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities

Lignins from Agroindustrial by-Products as Natural Ingredients for Cosmetics: Chemical Structure and In Vitro Sunscreen and Cytotoxic Activities

In Vitro Antimicrobial, Antioxidant Activities and Phytochemical Analysis of Canarium patentinervium Miq. from Malaysia

Synergism on antioxidant activity between natural compounds optimized by response surface methodology

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