Effect of bulk microstructure of commercially pure titanium on surface characteristics and fatigue properties after surface modification by sand blasting and acid-etching

Medvedev, Alexander E.; Ng, Hoi Pang; Lapovok, Rimma; Estrin, Yuri; Lowe, Terry C.; Anumalasetty, Venkata N.

doi:10.1016/j.jmbbm.2015.11.035

Cited by 61 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The micro-roughened topography formed by these techniques increases the surface area and promotes cell adhesion; however, this also affects the mechanical properties by creating cracks nucleation and compromises the proliferation of osteoblasts. 12,13 In recent years, TiO 2 nanotubes (TNT) prepared by the anodic oxidation technique have attracted much attention because these mimic the fundamental nanoscale structure of the bone and demonstrate superior biocompatibility and osseointegration abilities. 1,14 Several studies have shown that TNTmodified surfaces show improved cell adhesion and proliferation abilities, alkaline phosphatase (ALP) activity, and bone mineralization.…”

Section: Introductionmentioning

confidence: 99%

TiO2 Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition

Yang

Zhang

Chan

et al. 2020

IJN

View full text Add to dashboard Cite

Background: Patients with diabetes mellitus (DM) have a higher failure rate of dental implant treatments. However, whether titanium (Ti) implants with TiO 2 nanotubes (TNT) surface can retain their biocompatibility and osteogenetic ability under DM conditions has not been investigated; in addition, their behavior in DM conditions is not well characterized. Materials and Methods: Pure Ti discs were surface treated into the polishing (mechanically polished, MP), sandblasted and acid-etched (SLA), and TNT groups. Scanning electron microscopy was used to examine the surface morphology. The cell adhesion and proliferation ability on different modified Ti surfaces at various glucose concentrations (5.5, 11, 16.5, and 22 mM) was detected by the CCK-8 assay. The osteogenetic ability on different modified Ti surfaces under high-glucose conditions was evaluated by alkaline phosphatase (ALP), osteopontin (OPN) immunofluorescence, Western blot, and Alizarin Red staining in vitro. Detection of cell apoptosis and intracellular reactive oxygen species (ROS) was undertaken both before and after N-acetylcysteine (NAC) treatment to assess the oxidative stress associated with different modified Ti surfaces under high-glucose conditions. An in vivo study was conducted in DM rats with different modified Ti femoral implants. The osteogenetic ability of different modified Ti implants in DM rats was assessed using a micro-CT scan. Results: High-glucose conditions inhibited cell adhesion, proliferation, and osteogenetic ability of different modified Ti surfaces. High-glucose conditions induced higher apoptosis rate and intracellular ROS level on different modified Ti surfaces; these effects were alleviated by NAC. Compared with the SLA surface, the TNT surface alleviated the osteogenetic inhibition induced by high-glucose states by reversing the overproduction of ROS in vitro. In the in vivo experiment, micro-CT scan analysis further confirmed the best osteogenetic ability of TNT surface in rats with DM. Conclusion: TNT surface modification alleviates osteogenetic inhibition induced by DM. It may provide a more favorable Ti implant surface for patients with DM.

show abstract

Section: Introductionmentioning

confidence: 99%

TiO2 Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition

Yang

Zhang

Chan

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…In recent decades, implant-supported denture has become the primary restorative procedure for total and partial edentulism because of its good stability, realistic aesthetics, comfort, and the ability to avoid natural tooth preparations. Titanium (Ti) and its alloys have been widely used for implant materials owing to their desirable properties such as high mechanical strength, light weight, and excellent biocompatibility 1 . Primary stability, which is defined as the biometric stability immediately after implant insertion, has a major impact on the long-term success of dental implants.…”

Section: Introductionmentioning

confidence: 99%

Effects of aspirin-loaded graphene oxide coating of a titanium surface on proliferation and osteogenic differentiation of MC3T3-E1 cells

Ren

Pan

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Graphene oxide (GO) has attracted considerable attention for biomedical applications such as drug delivery because of its two-dimensional structure, which provides a large surface area on both sides of the nanosheet. Here, a new method for titanium (Ti) surface modification involving a GO coating and aspirin (A) loading (A/Ti-GO) was developed, and the bioactive effects on mouse osteoblastic MC3T3-E1 cells were preliminarily studied. The X-ray photoelectron spectrometry indicated new C-O-N, C-Si-O-C, and C-N=C bond formation upon GO coating. Remarkably, the torsion test results showed stable bonding between the GO coating and Ti under a torsional shear force found in clinical settings, in that, there was no tearing or falling off of GO coating from the sample surface. More importantly, through π-π stacking interactions, the release of aspirin loaded on the surface of Ti-GO could sustain for 3 days. Furthermore, the A/Ti-GO surface displayed a significantly higher proliferation rate and differentiation of MC3T3-E1 cells into osteoblasts, which was confirmed by a water-soluble tetrazolium salt-8 (WST-8) assay and alkaline phosphatase activity test. Consequently, Ti surface modification involving GO coating and aspirin loading might be a useful contribution to improve the success rate of Ti implants in patients, especially in bone conditions.

show abstract

“…Sandblasting uses a projectile of abrasive particles (such as aluminium oxide, titanium oxide, or HAP) under high pressure that collides with the target surface (Medvedev et al, ; Salou, Hoornaert, Louarn, & Layrolle, ; Schwarz, Sager, Kadelka, Ferrari, & Becker, ). Another common treatment for obtaining smooth sized features is acid‐etching (Herrero‐Climent et al, ; Medvedev et al, ; Saulacic, Erdosi, Bosshardt, Gruber, & Buser, ; Wennerberg, Svanborg, Berner, & Andersson, ). After performing dissolution of the original oxide layer, the selective dissolution of the substrate grains results in the acid etching process (El‐wassefy, Hammouda, Habib, El‐Awady, & Marzook, ).…”

Section: Osteobiologic Materialsmentioning

confidence: 99%

Advances in osteobiologic materials for bone substitutes

Hasan

Byambaa

Morshed

et al. 2018

J Tissue Eng Regen Med

105

View full text Add to dashboard Cite

A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts, and xenografts and thereby serve as implant materials as bone substitutes for bone repair or remodelling. The complex biology behind the nanostructure and microstructure of bones and their repair mechanisms, which involve various types of chemical and biomechanical signalling amongst different cells, has set strong requirements for biomaterials to be used in bone tissue engineering. This review presents an overview of various types of osteobiologic materials to facilitate the formation of the functional bone tissue and healing of the bone, covering metallic, ceramic, polymeric, and cell-based graft substitutes, as well as some biomolecular strategies including stem cells, extracellular matrices, growth factors, and gene therapies. Advantages and disadvantages of each type, particularly from the perspective of osteoinductive and osteoconductive capabilities, are discussed. Although the numerous challenges of bone regeneration in tissue engineering and regenerative medicine are yet to be entirely addressed, further advancements in osteobiologic materials will pave the way towards engineering fully functional bone replacement grafts.

show abstract

Effect of bulk microstructure of commercially pure titanium on surface characteristics and fatigue properties after surface modification by sand blasting and acid-etching

Cited by 61 publications

References 30 publications

<p>TiO<sub>2</sub> Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition</p>

<p>TiO<sub>2</sub> Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition</p>

Effects of aspirin-loaded graphene oxide coating of a titanium surface on proliferation and osteogenic differentiation of MC3T3-E1 cells

Advances in osteobiologic materials for bone substitutes

Contact Info

Product

Resources

About