Effect of Buffer Species on the Complexation of Basic Drug Terfenadine with β-Cyclodextrin

Novel inclusion complex of ibuprofen tromethamine with cyclodextrins: Physico-chemical characterization

“…suggesting that the counter cation is positioned outside but opposite to one of the ␤-CyD cavity rims. This is in agreement with the data reported earlier for terfenadine/citric acid/␤-CyD, ketoconazole/tartaric acid/␤-CyD, econazole/malic acid/␣-CyD ternary systems [31][32][33], where the counter anion is located outside of the CyD cavity. However the downfield shift of (h) proton might indicate slight interaction of tromethamine with the hydrophilic, exterior edges of ␤-CyD.…”

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

“…Data for several structurally unrelated drugs were collected for which the input parameters for binding and physicochemistry are experimentally determined and available in the literature, bringing the total number of drugs studied to 92 (25 acids, 37 neutrals, 30 bases) 1–20. The hepatocyte binding data in rats (Sprague–Dawley) and humans were compiled from several sources and methods: viable suspended hepatocytes using oil centrifugation (using live cells), dialysis (using dead cells), and ultrafiltration (using dead cells) 8–13.…”

Perspectives in solubility measurement and interpretation

“…Solid state characterizations were not reported for the above HTS measurements. [29]. Dotted curve is best-fit of 23-h equilibration data; solid curve is best-fit of 68h data.…”

“…Dotted curve is best-fit of 23-h equilibration data; solid curve is best-fit of 68h data. As a visual guide, the dashed curve is the HH curve calculated for crystalline terfenadine, based on the analysis of the data from Al Omari et al (2007) [29], shown in the frame on the right. (b) Shake-flask thermodynamic measurements [29].…”