Effect of Brown Algae Cystoseira trinodis Methanolic Extract on Renal Tissue

Gazor, Rouhollah; Pasdaran, Ardalan; Almasi, Shabnam; Ghasemi, Saeed

doi:10.15171/ps.2016.09

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…Significant results were observed in Groups B, I, J, K, and L. The I and J groups were administered 500 mg and 250 mg of ethyl acetate extracts of M. sinensis , respectively, while the K and L groups received 500 mg and 250 mg of ethanol extracts, respectively. Previously, n-hexane-derived extracts from A. villosus have been found to have significant hepatoprotective effects ( Gazor et al, 2017 ). This study explored the phytochemical composition, anti-hyperglycemic activity, and effects of A. villosus and extracts on the kidney and liver.…”

Section: Discussionmentioning

confidence: 99%

“…Serum creatinine was measured using a commercial kit (Cromatest creatinine kit) following the Jaffe method ( Küme et al, 2018 ) by the Spectrophotometer (Ryto 9200 semi-auto analyzer at Health Garden Diagnostic Centre) with 510 nm wavelength. From the same serum source, Alkaline phosphatase was measured using a commercial kit (Cromatest Alkaline Phosphatase kit) according to DGKC method ( Gazor et al, 2017 ) by Spectrophotometer (Ryto 9200 semi-auto analyser at Health Garden Diagnostic Centre) with 405 nm wavelength.…”

Section: Methodsmentioning

confidence: 99%

“…Using these approaches, the existing phytochemicals in these plants have been optimized, and therapeutic properties to treat diabetes have been enhanced. Computer-aided drug designing (CADD) analysis can hasten the drug development process by screening large compounds to predict their toxicity and select them as lead compounds ( Gazor et al, 2017 , Grover et al, 2003a , Küme et al, 2018 ). For identification of possible active conformation, binding affinity strain discipline associated with the binding mechanism has been performed by Quantum mechanics ( Socrates, 2004 ) and Molecular docking to detect binding affinity and interaction between protein and ligand molecules ( Grant-Peters et al, 2022 , Saha et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Nur Kabidul Azam,

Biswas,

Mohaimenul Islam Tareq

et al. 2024

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Nur Kabidul Azam,

Biswas,

Mohaimenul Islam Tareq

et al. 2024

Saudi Pharmaceutical Journal

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“…Cystoseira trinodis, Padina boryana, and Turbinaria triquetra are 3 brown seaweeds that are used in food and folk medicine in many cultures. [8][9][10] The species have been studied for their bioactive compounds and bioactivities. Phlorotannin have been isolated from C. trinodis.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial Activity, and Molecular Docking of the Main Phytoconstituents from Three Rarely Investigated Marine Macroalgae

Osman,

Nafie,

Kang

et al. 2024

Natural Product Communications

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Objective: This study aimed to investigate the phytochemical and mineral compositions, antimicrobial activities, and molecular docking of 3 abundant and understudied seaweeds ( Cystoseira trinodis, Padina boryana, and Turbinaria triquetra). Methods: Extraction was performed using absolute ethanol, and chemical and mineral compositions were determined using the standard methods of the Association of Official Analytical Chemists. Total phenolics and flavonoids were assessed using the Folin-Ciocalteu and aluminum chloride methods, respectively. Chemical composition was screened using gas chromatography-mass spectrometry (GC-MS), and antimicrobial activity was evaluated using a disc diffusion assay. In addition, molecular docking analysis of the main compounds was performed. Results: The samples had high ash, carbohydrate, and fiber contents. The results showed high amount of Na, K, Mg, Ca, and Fe, with the highest values for Ca. Trace elements such as Cu, Mn, and Zn were found in low amounts in the studied species. The content of total phenolics ranged from 15.54 ± 0.1 to 39.5 ± 0.2 mg gallic acid equivalent/g. For flavonoid, it ranged from 3.4 ± 0.3 to 1.5 ± 0.2 mg rutin/g. GC-MS revealed 9 major compounds, mainly fatty acids, which have been reported to have antimicrobial activity. The antimicrobial results indicated a higher impact of the extracts against bacteria ( Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Proteus vulgaris) than against fungi ( Candida albicans and Aspergillus fumigatus), and a stronger dose-dependent effect against gram-positive ( B. subtilis and S. aureus) bacteria than against gram-negative bacteria ( E. coli and P. vulgaris). Molecular docking identified 1,2-benzenedicarboxylic acid mono(2-ethylhexyl) ester as the highest binding compound for penicillin-binding protein 6, suggesting its potential antimicrobial activity. Conclusion: These findings suggest that these seaweed species could serve as promising sources of functional foods with antimicrobial properties, with potential applications in the nutraceutical and pharmaceutical fields.

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“…When the literature studies are examined, Acantholimon austroiranicum, Acantholimon bracteatum (Girard) Boiss., Acantholimon gilliati, Acantholimon longiscapum, Acantholimon serotinum, Acantholimon scorpius, and Acantholimon chlorostegium plants were tested for antimicrobial, antitumor, insecticide, cytotoxicity, liver protective, and antioxidant activity. Studies have shown that Acantholimon species have therapeutic properties [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Methanol Extracts of Some Acantholimon Boiss (Plumbaginaceae) Species

Bülbül

Bekmezci

Bayat

et al. 2023

Journal of Scientific Reports-A

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In this study, antimicrobial, antifungal, and antibiofilm properties and antioxidant capacities were examined on 15 bacteria and 2 fungus species. As a result of antimicrobial studies performed with the Agar Well Diffusion method, it was noted that the plants formed a zone diameter of approximately 12-18 cm, and the minimum concentrations were determined with the MIC and MBC test systems. Acantholimon species examined for their antibiofilm properties showed a biofilm reduction tendency of 10-50% in almost all bacteria at concentrations of 8 mg/ml - 16 mg/ml. MCF-7 cell line IC50 values were calculated as 0.143 mg/ml for A.kotschyi, 0.63 mg/ml for A.libanoticum, 0.123 mg/ml for A. armenum var. balansae and 0.107 mg/ml for A. acerosum subsp. brachystachyum (Boiss.). When the IC50 values on HUVEC and MCF-7 cell lines were examined, it was determined that the tested Acantholimon species showed cytotoxic effects on the MCF-7 cell lines but did not show cytotoxic effects at the same concentrations on the HUVEC cell line.

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Effect of Brown Algae Cystoseira trinodis Methanolic Extract on Renal Tissue

Cited by 4 publications

References 20 publications

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Identification of antidiabetic inhibitors from Allophylus villosus and Mycetia sinensis by targeting α-glucosidase and PPAR-γ: In-vitro, in-vivo, and computational evidence

Chemical Composition, Antimicrobial Activity, and Molecular Docking of the Main Phytoconstituents from Three Rarely Investigated Marine Macroalgae

Antibacterial, Antifungal, Antibiofilm, Antioxidant, and Anticancer Properties of Methanol Extracts of Some Acantholimon Boiss (Plumbaginaceae) Species

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