Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease

Wilkie, Rosalie; Bryan, M. H.

doi:10.1016/s0022-3476(87)80087-2

Cited by 135 publications

(72 citation statements)

References 13 publications

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“…Bronchodilator therapy is effective in infants born preterm and is associated with improvements in lung function. A favourable response to the treatment has been described in ventilated infants (Sosulski et al 1986;Wilkie and Bryan 1987). Inhalation treatment using nebulisers is frequently chosen to treat asthma and bronchopulmonary dysplasia of premature infants, foals and horses with chronic respiratory problems.…”

Section: Original Papermentioning

confidence: 99%

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med.

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Surfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation are thought to play an important role in the development of respiratory distress syndrome in premature calves. Nebulised steroid (fluticasone), bronchodilator (salbutamol) and diuretics (furosemide) can be used in combination alongside standard treatment procedures for premature calves, and might improve viability as observed in infants, foals and horses with pulmonary disorders. Twenty-five premature calves with respiratory distress syndrome were used in this study. Oxygen and supportive treatment were administered to all groups. The first group was used as a control group (Group 1). The nebulised drug combinations were as follows: Group 2: fluticasone + salbutamol, Group 3: salbutamol + furosemide, Group 4: fluticasone + furosemide and Group 5: fluticasone + salbutamol + furosemide. During the 72-h time period of the study, fluticasone (15 µg/kg/12 h), salbutamol (0.025 mg/kg/6 h) and furosemide (1 mg/kg/12h) were applied for 5 min. Arterial blood samples were collected from the auricular artery at 0 h and at 1, 24, 48 and 72 h for blood gas analysis. Significant (P < 0.05) increases in arterial partial oxygen, oxygen saturation and peripheral oxygen saturation and decreases in arterial partial carbon dioxide, lactate and respiration rate were observed in all the nebulised treatment groups, while a statistical difference was observed only for arterial partial carbon dioxide in control group. When comparing the treated groups with the control, it may be concluded that nebulised drugs are highly effective in the therapy of premature calves with respiratory distress syndrome, while the different nebulised groups exhibited similar efficacies.

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Section: Original Papermentioning

confidence: 99%

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med.

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“…Bronchodilator aerosols are commonly used for the treatment of bronchiolar constriction associated with chronic lung disease of the newborns [1][2][3][4][5][6][7][8][9]. The aerosols may be delivered by a metered dose inhaler (MDI) used in conjunction with a spacer device, a jet nebulizer, or an ultrasonic nebulizer.…”

mentioning

confidence: 99%

Delivery of salbutamol to nonventilated preterm infants by metered-dose inhaler, jet nebulizer, and ultrasonic nebulizer

Fok¹,

Lam²,

Ng³

et al. 1998

Eur Respir J

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To identify the most efficient device for the delivery of bronchodilator aerosol to nonventilated preterm infants with chronic lung disease, we compared the metered dose inhaler (MDI) used in conjunction with a non-valved spacer, an ultrasonic nebulizer with a small medication cup, and two jet nebulizers. The subjects were enrolled in two double-blind randomized crossover studies. In study A (n=10), each infant was given a nominal dose of 200 microg of salbutamol by a MDI (Ventolin) at 4 h intervals, and in random sequence via an Aerochamber (Neonatal Aerochamber) with its one-way valve removed, an ultrasonic nebulizer with a small cone-shaped medication cup (Siemens Electronics), and a jet nebulizer (Side-stream). Their functional residual capacity (FRC) and static respiratory system mechanics were measured before, and at 15, 30, 60, and 120 min after aerosol delivery. Study B (n=10) was carried out in an identical manner, but with a different jet nebulizer (Hudson). In both studies, administration of salbutamol aerosol via the MDI Aerochamber or ultrasonic nebulizer resulted in a significantly greater reduction in respiratory system resistance than via jet nebulizers. Furthermore, the use of MDI Aerochamber or ultrasonic nebulizer was associated with a greater degree of post-treatment tachycardia and improvement in FRC. The bronchodilating effect of salbutamol delivered via the ultrasonic nebulizer appeared to be slightly greater than that via the MDI-Aerochamber, receiving significance only in Study B. We conclude that both the metered-dose inhaler used with a nonvalved Aerochamber and the ultrasonic nebulizer with a small medication cup are both more efficient than the jet nebulizers in preterm infants.

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“…A fall in rate of breathing has been reported in pretenn babies ventilated for respiratory distress syndrome after receiving 20 pg of IB down the endotracheal tube (46). A reduction in pulmonary resistance and an increase in compliance have been observed in ventilatordependent premature infants with BPD after a single dose of nebulized IB (25 &kg) (47). Similarly, a reduction in airways resistance and an increase in forced expiratory flow rates have been observed after nebulized atropine in BPD infants after extubation (48).…”

Section: Respiratory Distress Syndrome and Bronchopulmonary Dysplasiamentioning

confidence: 86%

Anticholinergic antimuscarinic agents in the treatment of airways bronchoconstriction in children

Martinati¹,

Boner²

1996

Allergy

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Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease

Cited by 135 publications

References 13 publications

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Delivery of salbutamol to nonventilated preterm infants by metered-dose inhaler, jet nebulizer, and ultrasonic nebulizer

Anticholinergic antimuscarinic agents in the treatment of airways bronchoconstriction in children

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