Effect of Bronchoalveolar Lavage With Sodium Bicarbonate on Lower Respiratory Tract Pathogens

Abdalla, Dina Abouelkheir; Badrawy, Mohammad El; Elela, Mohammad Abou; El-Khier, Noha Tharwat Abou; Abdelgawad, Taha Taha; Moawad, Amro; Yousef, Aida M.

doi:10.1016/j.chest.2016.02.093

Cited by 4 publications

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“…It has been found that the changing acidic pH in pulmonary tuberculosis (TB) lesion may affect growth of TB bacilli. Previous studies have found that the effect of adjuvant inhalation of sodium bicarbonate (SB) 8.4% in smear-positive pulmonary TB to standard anti-TB drugs accelerates smear conversion, culture conversion, and clinical and radiological improvement [53,54]. Patients with renal tubular acidosis syndromes or diarrhoea are given chronic bicarbonate replacement therapy.…”

Section: Probable Effects Of Sodium Bicarbonate To Circumvent Covid-1mentioning

confidence: 99%

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2020

FARMACIA

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SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. SARS-Cov-2 entrance into the host cells is reliant on acidic pH. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbonate as an alternative lysosomotropic agent based on the reported literature owing to its anti-flu properties and widespread use during 1918 Spanish flu pandemic. The suggestions put forward in the current review article based on the careful use of sodium bicarbonate could probably help to restrain SARS-CoV-2 infection. Rezumat COVID-19 a generat o criză de sănătate publică globală cu consecințe uriașe până în prezent, în principal din cauza lipsei agenților terapeutici specifici. Pătrunderea SARS-Cov-2 în celulele gazdă depinde de pH-ul acid. Astfel, în situația clinică actuală este nevoie de terapii adjuvante care ar putea contracara pH-ul acid, pentru a limita penetrarea virusului la nivel celular. Prin urmare, studiul de față explorează posibilitatea utilizării bicarbonatului de sodiu ca agent lizozomotrop alternativ, pe baza datelor referitoare la gripa spaniolă din 1918. Sugestiile prezentate în actualul articol, privind utilizarea bicarbonatului de sodiu, ar putea ajuta contribui la limitarea infecțiilor cu SARS-CoV-2.

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Section: Probable Effects Of Sodium Bicarbonate To Circumvent Covid-1mentioning

confidence: 99%