Effect of bromide ions on genotoxicity of halogenated by-products from chlorination of humic acid in water

Nobukawa, Takako; Sanukida, Satoshi

doi:10.1016/s0043-1354(01)00157-9

Cited by 33 publications

(18 citation statements)

References 24 publications

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“…A mass of bromide-containing wastewater was produced after reaction, and ozonation these organic contaminants can produce bromate and other brominated pollutants [12,13] inant level of 10 g/L for bromate in finished water [14,15]. Brominated by-products are suspected to be more harmful to health than their chloride-containing analogues [16]. Therefore, it is necessary and significant to removal the DBPs (disinfection by-products) precursor bromide.…”

Section: Introductionmentioning

confidence: 99%

Bromide ion removal from contaminated water by calcined and uncalcined MgAl-CO3 layered double hydroxides

Wang

Wei

et al. 2008

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Bromide ion removal from contaminated water by calcined and uncalcined MgAl-CO3 layered double hydroxides

Wang

Wei

et al. 2008

Journal of Hazardous Materials

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“…Furthermore, a variety of both chlorinated and nonchlorinated organic products has been shown to be formed as a result of disinfection of water that contains humic material [1][2][3]62].…”

Section: Discussionmentioning

confidence: 99%

“…It is essentially an oxidative, halogenating, degradation process with simultaneous substitution, addition, elimination, rearrangement and hydrolytic reactions taking place, resulting in a large variety of end products, not all fully characterized [5,62]. This chain of reactions is highly dependent upon the level of chlorination, total organic carbon, and other physico-chemical parameters [5,53].…”

Section: Discussionmentioning

confidence: 99%

Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio

Gustavino

Buschini

Monfrinotti

et al. 2005

Mutation Research/Genetic Toxicology and Environmental Mutagene

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The use of chlorinated disinfectants during drinking-water production has been shown to generate halogenated compounds as a result of interactions of humic acids with chlorine. Such chlorinated by-products have been shown to induce genotoxic effects and consumption of chlorinated drinking-water has been correlated with increased risk for cancer induction in human populations. The aim of this work was to test the potential genotoxic effects on circulating erythrocytes of the fish Cyprinus carpio exposed in vivo to well-waters disinfected with sodium hypochlorite (NaClO), chlorine dioxide (ClO 2 ) or peracetic acid (CH 3 COO 2 H, PAA), in the absence or presence of standard humic acids (HA). The effects were measured by use of the micronucleus (MN) and the single-cell gel electrophoresis (Comet) assays at different sampling times after a 3-day exposure period. The exposure to chlorine disinfectants without the addition of HA produced a clear toxic effect. Significant cytogenetic damage (i.e. MN induction) was detected in fish populations exposed to both NaClO and ClO 2 with humic acids. In the Comet assay, a significant decrease of DNA migration was observed in erythrocytes of specimens after exposure to NaClO-disinfected water without HA. No effects were observed in any other experimental condition.

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“…However, several studies (Krasner 1993;Amy 1994;Richardson et al 2000;von Gunten 2003a) demonstrated that bromate and other organic by-products are generated during ozonation of natural water. Brominated byproducts are more harmful to human health and much stronger carcinogens and mutagens than their chlorinated analogues (LaLonde et al 1997;Nobukawa and Sanukida 2001). Hypochlorous acid (HOCl) and hypochlorite ions (OCl − ) typically oxidize bromide ions (Br − ) into hypobromous acid (HOBr) and hypobromite ions (OBr − ); both HOCl and HOBr are implicated in the production of trihalomethanes (THMs), including chloroform (CHCl 3 ) and bromoform (CHBr 3 ).…”

Section: Introductionmentioning

confidence: 99%

Disinfection by-product formation and mutagenic assay caused by preozonation of groundwater containing bromide

Huang

Chang

Shih

2008

Environ Monit Assess

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Brominated organic and inorganic by-products are generated during ozonation of groundwater containing high bromide concentrations. This study measured concentrations of bromate, bromoform, bromoacetic acids, bromoacetonitriles, bromoacetone, 2,4-dibromophenol and aldehyde generated by ozonation. The potential mutagenicity of ozonated waters was assessed using the Ames and Microtox tests. Test results for the 18 ozonated groundwater samples demonstrate that bromate formation is associated with high pH, bromide and alkalinity content, low levels of dissolved organic carbon (DOC) and ammonia, and low alkalinity. Brominated organic by-products were correlated with high bromide ion and natural organic matter content, and low ammonia concentrations. The Ames test results demonstrate that all extracts from ozonated water have mutagenic activity; however, the 18 raw groundwater samples had no mutagenicity. The Microtox test results also show that the ozonated water samples were highly toxic. Generally, both bromide and DOC content promoted the formation of ozonation by-products and mutagenicity. Controlling of bromide and DOC concentrations is an effective method of reducing potential by-product formation and eliminating mutagenicity problems associated with groundwater ozonation.

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Effect of bromide ions on genotoxicity of halogenated by-products from chlorination of humic acid in water

Cited by 33 publications

References 24 publications

Bromide ion removal from contaminated water by calcined and uncalcined MgAl-CO3 layered double hydroxides

Bromide ion removal from contaminated water by calcined and uncalcined MgAl-CO3 layered double hydroxides

Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio

Disinfection by-product formation and mutagenic assay caused by preozonation of groundwater containing bromide

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