Effect of Broccoli Sprouts on Cholesterol-lowering and Anti-obesity Effects in Rats Fed High Fat Diet

이재준,; 신형덕,; 이유미,; 김아라,; 이명렬,

doi:10.3746/jkfn.2009.38.3.309

Cited by 35 publications

(20 citation statements)

References 18 publications

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“…Broccoli sprout extract has shown hypocholesterolaemic effects and to reduce body-weight (BW) gain in Syrian hamsters ( 14 ) and in rats fed a HFD ( 15 ) , respectively. A phase 1 study has reported improved cholesterol metabolism and decreased oxidative stress markers, in healthy subjects who consumed broccoli sprouts for 1 week ( 16 ) .…”

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confidence: 99%

Protective effect of Tuscan black cabbage sprout extract against serum lipid increase and perturbations of liver antioxidant and detoxifying enzymes in rats fed a high-fat diet

et al. 2013

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A diet rich in fat is considered a primary risk factor for CVD, cancer and failures in metabolism and endocrine functions. Hyperlipidaemia generates oxidative stress and weakens antioxidant defences as well as metabolic detoxification systems. Brassicaceae are vegetables rich in glucosinolates and isothiocyanates, affecting enzymatic antioxidant as well as phase II enzymes and conceivably counteracting high-fat diet (HFD)-associated pathologies. The protective role of Tuscan black cabbage (a variety of kale) sprout extract (TBCSE) intake against HFD alterations was here studied. The effects on rat hepatic antioxidant as well as detoxifying enzymes, and serum lipid-and body weightlowering properties of TBCSE, were investigated. Feeding the animals with a HFD for 21 d increased body as well as liver weights, and induced hyperlipidaemia, as confirmed by a higher serum lipid profile v. control diet. Daily intragastric administration of TBCSE to HFD-fed rats lowered serum total cholesterol, TAG and NEFA. Body and liver weight gains were also reduced. Antioxidant (catalase, NAD(P)H:quinone reductase, oxidised glutathione reductase and superoxide dismutase) and phase II (glutathione S-transferase and uridine diphosphate glucuronosyl transferase) enzymes were down-regulated by the HFD, while the extract restored normal levels in most groups. Generation of toxic intermediates, and membrane fatty acid composition changes by the HFD, might account for the altered hepatic antioxidant and detoxifying enzyme functions. The recovering effects of TBCSE could be attributed to high flavonoid, phenolic and organosulphur compound content, which possess free-radical-scavenging properties, enhance the antioxidant status and stimulate lipid catabolism. TBCSE intake emerges to be an effective alimentary strategy to counteract the perturbations associated with a diet rich in fat.

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confidence: 99%

Protective effect of Tuscan black cabbage sprout extract against serum lipid increase and perturbations of liver antioxidant and detoxifying enzymes in rats fed a high-fat diet

et al. 2013

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“…Such treatment exerted a clear influence on lipid metabolism; HDL-cholesterol increased (29%) and serum TG concentrations dropped down (13%) (Okulicz et al 2010). Lee et al (2009) also confirmed a reduction in plasma total cholesterol, LDL-cholesterol, TG, and an increase in HDL-cholesterol in male Spraque-Dawley rats after a 4-week consumption of 400 mg/kg BW ethanolic extract from broccoli sprouts. Because all the above presented results were obtained after chronic SF treatment, the unexpected lack of changes in total cholesterol in the present trial (Table 1) seems to be due to a limited time of SF action.…”

Section: Discussionmentioning

confidence: 53%

“…However, the knowledge about SF influence on metabolism has been related only to its long-term action. SF has been shown to elicit a reduction of plasma total cholesterol, LDLcholesterol, triacylglycerols (TG), and an increase in HDL-cholesterol in numerous long-term clinical and animal studies (1-7 weeks treatments) (Murashima et al 2004;Lee et al 2009;RodriguezCantu et al 2011;Bahadoran et al 2012a). In our laboratory, long-running oral administration of SF (10 mg/kg BW, i.e.…”

Section: Introductionmentioning

confidence: 99%

Acute sulforaphane action exhibits hormonal and metabolic activities in the rat: in vivo and in vitro studies

Okulicz¹,

Hertig²

2016

CZECH J ANIM SCI

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So far, only the chronic effect of sulforaphane (SF) on metabolism was examined. This study sheds more light on SF potential ability of regulating lipid, carbohydrate, and hormonal metabolism during its acute action in in vivo and in vitro conditions. In the in vivo trial, rats were given once intragastrically 10 or 20 mg/kg of SF and were decapitated 4 h after the single intragastric treatment. The serum and the liver were collected to assay lipid, carbohydrate, and hormonal parameters. Additionally, we evaluated the acute direct in vitro action of SF (1.5 h) on basal and insulin-stimulated lipogenesis and basal and epinephrine-induced lipolysis in isolated primary rat adipocytes at 1µM, 10µM, and 100µM concentrations. The SF hormonal action was dose-dependent. In the in vivo trial, the higher dose evoked a significant insulin release (P ≤ 0.01) and showed a tendency to limit the secretion of leptin from adipocytes compared with the control animals. Surprisingly, two applied SF doses did not cause any changes in serum glucose level and liver glycogen content. Both SF doses reduced HDL-and increased LDL-cholesterol level (P ≤ 0.05), evoked a drop of liver triacylglycerol content (P ≤ 0.05) compared with the control rats. In the in vitro study, only 100µM SF evoked elevation of basal-and epinephrine-induced lipolysis and inhibition of basal-and insulin-induced lipogenesis in comparison with the control (P ≤ 0.001). SF adipocyte influence was independent of epinephrine and insulin action. Recapitulating, SF exhibited a tendency towards limiting lipid synthesis in adipocytes as well as in the liver, possibly via Nrf2 pathway. The disturbance in the LDL-to HDL-cholesterol ratio and dose-dependent increase in insulin concentration at normal glycaemia were connected probably with the SF capability to generate temporarily ROS in the pancreas and in the vascular endothelial cells in in vivo trials.

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“…It is highly nutritious and contains a wide range of health-promoting phytochemicals such as GSLs, vitamins, phenols, flavonoids, selenium, glutathione, and carotenoids (Sok et al, 2003;Wang et al, 2012;Bhandari and Kwak, 2015). Broccoli shows different beneficial health properties, such as anti-obesity and cholesterol-lowering effects (Lee et al, 2009), anti-inflammatory effects (Jang and Ha, 2012), anti-oxidative effects (Kim et al, 2001), and inhibition of the development of prostate (Joseph et al, 2004) and lung cancer (Spitz et al, 2000).…”

Section: Yearly Variation In Glucosinolate Content In Inflorescences mentioning

confidence: 99%

Yearly Variation in Glucosinolate Content in Inflorescences of Broccoli Breeding Lines

Jo,

Bhandari,

Kang

et al. 2018

HST

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This study aimed to evaluate yearly variation in individual glucosinolate (GSL) profiles and content in inflorescences of 42 broccoli genotypes (9 commercial cultivars, 16 F 1 hybrids, and 17 inbred lines) grown at the same location for two consecutive years (2014 and 2015). Broccoli heads were harvested at the marketable stage, and individual GSLs were analyzed using high performance liquid chromatography (HPLC). Eight GSLs, namely glucoiberin (IBE), progoitrin (PRO), epiprogoitrin (EPI), glucoraphanin (GRA), sinigrin (SIN), gluconapin (NAP), glucoerucin (ERU), and glucobrassicin (BRA) were identified in broccoli breeding lines grown in

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Effect of Broccoli Sprouts on Cholesterol-lowering and Anti-obesity Effects in Rats Fed High Fat Diet

Cited by 35 publications

References 18 publications

Protective effect of Tuscan black cabbage sprout extract against serum lipid increase and perturbations of liver antioxidant and detoxifying enzymes in rats fed a high-fat diet

Protective effect of Tuscan black cabbage sprout extract against serum lipid increase and perturbations of liver antioxidant and detoxifying enzymes in rats fed a high-fat diet

Acute sulforaphane action exhibits hormonal and metabolic activities in the rat: in vivo and in vitro studies

Yearly Variation in Glucosinolate Content in Inflorescences of Broccoli Breeding Lines

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