Effect of Brimonidine on Retinal and Choroidal Neovascularization in a Mouse Model of Retinopathy of Prematurity and Laser-Treated Rats

Abstract

BRI treatment significantly attenuated vitreoretinal VEGF concentrations, retinal vascular leakage, and retinal and choroidal neovascularization in animal models of ROP and CNV. BRI may inhibit underlying event(s) of ischemia responsible for upregulation of vitreoretinal VEGF and thus reduce vascular leakage and retinal-choroidal neovascularization.

Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics

“…Clinical studies with brimonidine 0.33% gel report significant reductions in erythema on both clinician‐ and patient‐reported scales with maximal effect 3–6 hours after drug application . Brimonidine acts by selectively binding to α2‐adrenergic receptors present on smooth muscle in the peripheral vasculature, resulting in transient local vasoconstriction and other vascular effects (Table ). Other α2 receptor agonists have further demonstrated the ability to reduce neutrophil extravasation and inhibit PGE2 release …”

Topical brimonidine reduces IPL‐induced erythema without affecting efficacy: A randomized controlled trial in patients with facial telangiectasias

“…The brimonidine‐induced reduction of erythema and pain is presumably due to vasoconstriction combined with an anti‐inflammatory effect, possibly due to reduced release of mast cells . Existing literature furthermore show that brimonidine reduces the concentration of vascular endothelial growth factor and thus in perspective, application of brimonidine not only once after IPL but for a longer time period may potentially maintain telangiectasia reduction . In contrast to pharmacological studies, including one in vivo study in mice that showed a significant reduction in oedema after application of brimonidine, we only found a clinical trend in favor of brimonidine to reduce IPL‐induced oedema compared to air‐cooling alone .…”

17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model

“…OIR is characterized by two pathological phases: early vaso-obliteration and late retinal neovascularization [20,21]. At present, the study and treatment of OIR and ROP focus on the late phase and not on the early phase [22][23][24][25][26].…”