Effect of bread containing stable fish oil on plasma phospholipid fatty acids, triglycerides, HDL-cholesterol, and malondialdehyde in subjects with hyperlipidemia

Liu, Meilin; Wallin, Rolf; Saldeen, Tom

doi:10.1016/s0271-5317(01)00353-0

Cited by 36 publications

(27 citation statements)

References 15 publications

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“…This is in contrast to Haglund et al (1990), who reported a significant decrease in cholesterol and triacylglycerol concentrations to occur after 3 months in healthy subjects taking a large dose (14 g) of fish oil daily. In subjects with hyperlipidemia, Liu et al (2001) observed a significant increase in HDL cholesterol and decrease in triacylglycerols after 4 weeks but not 2 weeks, after intake of fish oil-enriched bread containing a small amount of fish oil.…”

Section: Discussionmentioning

confidence: 91%

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Effects of Scandinavian caviar paste enriched with a stable fish oil on plasma phospholipid fatty acids and lipid peroxidation

2003

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Objective: To study the possibility of increasing the very long-chain n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in humans by means of consumption of a common food product, Scandinavian caviar paste, suitable for strategic enrichment with a high concentration of these fatty acids, and to measure the potential inducement of lipid peroxidation. Design: A randomized double blind repeated measures experiment. Subjects and interventions: In total, 16 healthy, nonsmoking subjects (eight men and eight women, age 42712 y) were included in the study. Eight consumed 25 g ordinary caviar paste daily for 3 weeks, and eight the same amount of caviar paste enriched with a very stable fish oil (7%, wt/wt). Blood lipids, plasma phospholipid fatty acids and lipid peroxidation were measured. Results: a-Linoleic acid was significantly decreased after intake of both ordinary (À8%, Po0.05) and fish oil caviar (À10%, Po0.05), as was the sum of all n-6 fatty acids (À6%, Po0.05 and À8%, Po0.001, respectively). The fatty acids EPA and DHA, as well as the sum of all n-3 fatty acids, increased significantly in both caviar groups but more in the group given fish oil caviar paste (EPA: +51%, Po0.05 and +100%, Po0.001, respectively; DHA: +24%, Po0.01 and +29%, Po0.001, respectively; sum of n-3:+27%, Po0.05 and +40%, Po0.001, respectively). Lipid peroxidation, measured as the thiobarbituric acidFmalondialdehyde adduct, was increased by 26% (Po0.05) after intake of ordinary caviar paste, but was unchanged after intake of fish oil-enriched caviar paste. Conclusion: Scandinavian caviar paste is a spread naturally enriched with n-3 polyunsaturated fatty acids that can be included in the diet to achieve an increase in these fatty acids. However, changing to caviar paste enriched with stable fish oil will lead to a considerably greater increase in EPA and DHA.

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Section: Discussionmentioning

confidence: 91%

“…In two earlier investigations, we studied the effect of fish oil introduced into bread, a food consumed by most people in large amounts, on some risk factors for ischemic heart disease (Saldeen et al, 1998;Liu et al, 2001). In the present study, we have focused on another food suitable for enrichment, namely Scandinavian caviar paste.…”

Section: Introductionmentioning

confidence: 99%

Effects of Scandinavian caviar paste enriched with a stable fish oil on plasma phospholipid fatty acids and lipid peroxidation

2003

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“…A growing number of products fortified in this way are now available in Europe and are considered to be both bioavailable and have the capacity to increase population intakes of LC n-3 PUFA (Higgins et al 1999). An intervention study which gave fortified bread (providing 270 mg EPA and 195 mg DHA/d) to thirty-six volunteers with hyperlipidaemia found that plasma LC n-3 PUFA increased significantly after 4 weeks, while plasma levels of triacylglycerols decreased and HDL increased (Liu et al 2001). This suggests the value of fortified foods, particularly in populations where oil-rich fish intakes are low.…”

Section: Food Sourcesmentioning

confidence: 99%

The impact of long-chainn-3 polyunsaturated fatty acids on human health

et al. 2005

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A considerable literature has been published on the health benefits of fish, oil-rich fish and fish oils and their constituent long-chain (LC)n-3 PUFA. Evidence from epidemiological studies highlights the cardioprotective attributes of diets rich in fish, especially oil-rich fish. Data from intervention trials are consistent in suggesting that LCn-3 PUFA lower the risk of CVD, probably by the multiple mechanisms of lowering serum triacylglycerols, improving the LDL:HDL ratio, anti-arrhythmic effects on heart muscle, improved plaque stability, anti-thrombotic effects and reduced endothelial activation. Research indicates LCn-3 PUFA provision has an impact during development, and there is preliminary evidence that docosahexaenoic acid supplementation during pregnancy could optimise brain and retina development in the infant. LCn-3 PUFA are also postulated to ameliorate behavioural and mental health disturbances such as depression, schizophrenia, dementia and attention deficit hyperactivity disorder. However, despite some positive evidence in each of these areas, use of LCn-3 PUFA in these conditions remains at the experimental stage. In the case of immune function, there is little doubt that LCn-3 PUFA have a positive effect. Although intervention trials in rheumatoid arthritis show strong evidence of benefit, evidence for efficacy in other inflammatory conditions, including Crohn's disease, ulcerative colitis, psoriasis, lupus, multiple sclerosis, cystic fibrosis and asthma, is inconsistent or inadequate. More promising evidence in some conditions may come from studies which attempt to modify the fetal environment using LCn-3 PUFA supplementation during pregnancy.

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“…Estudo in vitro também demonstrou efeito positivo do ácido graxo ômega-3 sobre produção de interleucina-6 e fibroblastos no processo de recuperação do ligamento colateral medial 11 . Além desses, outros estudos têm demonstrado efeitos benéficos e potencial efeito terapêutico da suplementação com ácido graxo ôme-ga-3 sobre inúmeros processos-doença, como hiperlipidemia, doença hepática alcoólica e trauma cerebral, dentre outros [12][13][14] . Contudo, apesar do crescente interesse pelos benefícios da suplementação com ômega-3 e seu potencial efeito terapêutico, até o momento não há estudos descrevendo os efeitos da suplementação oral com ácido graxo ômega-3 sobre marcadores de estresse oxidativo e processo inflamatório em indivíduos submetidos à intervenção fisioterápica pós-reconstrução do LCA.…”

Section: Grupo Omega-3 (Go) Suplementado Diariamente Con 2 G De Omegunclassified

Suplementação Com Ômega-3 Pós-Reconstrução Do Ligamento Cruzado Anterior

Vidmar

Siqueira

Brito

et al. 2016

Rev Bras Med Esporte

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reSumoIntrodução: As lesões do ligamento cruzado anterior (LCA) contribuem para a formação de radicais livres de oxigênio que, em excesso, podem desencadear dano oxidativo na articulação do joelho. Objetivo: Avaliar os efeitos da suplementação oral com ômega-3 sobre marcadores de estresse oxidativo em indivíduos submetidos à reconstrução do LCA. Métodos: Este estudo é um ensaio clínico prospectivo, randomizado, controlado e simples cego, com amostra de 25 indivíduos submetidos à reconstrução do LCA, separados aleatoriamente em: grupo ômega-3 (GO), suplementado diariamente com 2 g de ômega-3 durante 15 dias pós-reconstrução do LCA e grupo controle (GC), não suplementado. Foi realizada coleta de sangue e de líquido sinovial imediatamente antes do procedimento cirúrgico e 15 dias pós-reconstrução do LCA. As análises bioquímicas avaliaram os níveis de produtos de lipoperoxidação (MDA); atividade da catalase; grupos sulfidrílicos totais e polifenóis e proteína C reativa (PCR). Resultados: Observou-se diminuição significativa nos níveis de MDA no GO em comparação ao GC (p < 0,05), da mesma forma que a atividade da enzima antioxidante catalase foi significativamente menor no GO quando comparado ao GC (p < 0,001). Também foram observados níveis significativamente elevados de grupos sulfidrílicos totais no plasma dos indivíduos suplementados quando comparados aos do GC (p < 0,001). Além disso, foram observados níveis significativamente maiores de polifenóis (p < 0,05) tanto no plasma quanto no líquido sinovial dos indivíduos que receberam ômega-3 no período pós-cirúrgico comparado ao pré-cirúrgico. Entretanto, não foi observado um efeito protetor da administração do ômega-3 sobre a função anti-inflamatória. Conclusão: Verificamos um efeito protetor do ômega-3 na modulação dos marcadores de estresse oxidativo em indivíduos submetidos à reconstrução do LCA.descritores: joelho; ligamento cruzado anterior; suplementos nutricionais; ácidos graxos ômega-3. ABSTRACT introduction: the injuries of the anterior cruciate ligament (acl) contribute to the formation of oxygen free radicals, which in excess can

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Effect of bread containing stable fish oil on plasma phospholipid fatty acids, triglycerides, HDL-cholesterol, and malondialdehyde in subjects with hyperlipidemia

Cited by 36 publications

References 15 publications

Effects of Scandinavian caviar paste enriched with a stable fish oil on plasma phospholipid fatty acids and lipid peroxidation

Effects of Scandinavian caviar paste enriched with a stable fish oil on plasma phospholipid fatty acids and lipid peroxidation

The impact of long-chainn-3 polyunsaturated fatty acids on human health

Suplementação Com Ômega-3 Pós-Reconstrução Do Ligamento Cruzado Anterior

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