Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice

Abstract

We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose. Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.

Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells

“…Hence, this model presents the characteristic pathology of rhinitis such as sneezing, nasal rubbing, congestion, and edema. It is believed that nasal symptoms are mediated not only by histamine but also by prostaglandins, leukotrienes and trypase from activated mast cells, eosinophils and basophils (Martynova et al, 2005;Shinmei et al, 2009). In the present study, KOB03 remarkably inhibited rhinitis symptoms including the clinical scores, the morphological changes of nasal mucosa, and the histamine release in OVA-sensitized mice.…”

Propolis: Is there a potential for the development of new drugs?

“…It is a global health problem, affecting social life, sleep, school and work performance, regardless of gender, age and ethnic background (Hellgren et al, 2010). Shinmei et al (2009) studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice, concluding that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose.…”

Effect of KOB03, a polyherbal medicine, on ovalbumin-induced allergic rhinitis in guinea pigs

“…Nasal symptoms of AR are mediated by histamine and inflammatory mediators such as prostaglandins, leukotrienes, trypase and proinflammatory cytokines secreted from activated mast cells, eosinophils and basophils [3,17]. Mast cell-derived mediators collectively induce acute-phase clinical symptoms by enhancing vascular leakage, bronchospasm and activation of nociceptive neurons linked to parasympathetic reflex [18].…”

“…It is characterized by a local influx of eosinophils with clinical symptoms including nasal rubbing, sneezing, rhinorrhea, lacrimation, nasal congestion and obstruction [1,2]. AR also triggers systemic inflammation and is associated with various co-morbid conditions such as asthma, nasal polyposis, rhinosinusitis, serous otitis media and sleep disorders [3]. The inflammatory response in the nasal mucosa includes mast cell-mediated allergic responses and a late phase reaction characterized by inflammatory recruitment of secondary effector cells such as eosinophils, basophils, and T cells expressing T-helper 2 (Th2) cytokines including interleukin (IL)-4 (a switch factor for IgE synthesis) and IL-5 (an eosinophil growth factor that promotes allergic inflammation) [4].…”