Effect of branched-chain amino acids on food intake and indicators of hunger and satiety- a narrative summary

Lueders, Brianna; Kanney, Bradley C.; Krone, Martina J.; Gannon, Nicholas P.; Vaughan, Roger A.

doi:10.1016/j.hnm.2022.200168

Cited by 8 publications

(3 citation statements)

References 101 publications

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“…The decrease in feed and drink intake showed a similar pattern and was the highest in G2 (control) whereas the lowest was in group given CMP. As suggested by Lueders et al (2022) branched-chain amino acids regulate hunger by protein leveraging effect. Thus, adequate intake of branched-chain amino acids leads to less appetite suppression as compared to the control group.…”

Section: Feed and Water Intake Of Ratsmentioning

confidence: 99%

Effect of camel milk and pistachio-based product on cancer-induced sarcopenia in Sprague Dawley rats

Zahid

Zahoor

Sameen

et al. 2023

Food Sci. Technol (Campinas)

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In the current study, we investigated the role of camel milk and pistachio in the muscle growth of rats with cancer-induced sarcopenia. Female Sprague Dawley rats weighing 180 – 200 grams were selected for a bioefficacy trial for 13 weeks and divided into four groups: G1 (negative control), G2 (positive control), G3 (normal diet + camel milk), and G4 (normal diet + camel milk and pistachio based product). Tumors were induced in rats by administering 50 mg/kg of 7,12-dimethylbenz(a)anthracene via gastrogavage followed by chemotherapy in G2, G3, and G4. Histopathological analysis, muscle strength analysis, muscle fiber histology and renal function tests were performed. The administration of camel milk and pistachio-based product (CMP) significantly (P<0.01) improved muscle strength in the treatment group. Muscle mass analysis of the extensor digitorum longus (EDL) and soleus muscle showed significant (P<0.01) improvement in the treatment group. Muscle fiber diameter also significantly (P<0.01) increased in the treatment group. Camel milk and pistachio-based product (CMP) have shown promising effects against cancer-induced sarcopenia in rat modelling by enhancing muscle function and strength.

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Section: Feed and Water Intake Of Ratsmentioning

confidence: 99%

Effect of camel milk and pistachio-based product on cancer-induced sarcopenia in Sprague Dawley rats

Zahid

Zahoor

Sameen

et al. 2023

Food Sci. Technol (Campinas)

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“…Furthermore, BCAAs are involved in the activation of mammalian target of rapamycin (mTORC1), which, among others, promotes neuronal plasticity. BCAAs activate mTORC1 pathway that regulates the feedback mechanism of food intake and leads to anorectic response (Lueders et al, 2022). In contrast, inhibition leads to autophagy.…”

Section: Bcaasmentioning

confidence: 99%

The SLC6A15–SLC6A20 Neutral Amino Acid Transporter Subfamily: Functions, Diseases, and Their Therapeutic Relevance

Kukułowicz,

Pietrzak-Lichwa,

Klimończyk

et al. 2023

Pharmacol Rev

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The neutral amino acid transporter subfamily that consists of six members; consecutively SLC6A15-SLC620, also called orphan transporters, represents membrane, sodium-dependent symporter proteins that belong to the family of solute carrier 6 (SLC6). Primarily, they mediate the transport of neutral amino acids from the extracellular milieu toward cell or storage vesicles utilizing an electric membrane potential as the driving force. Orphan transporters are widely distributed throughout the body, covering many systems; for instance, the central nervous, renal, or intestinal system, supplying cells into molecules utilized in biochemical, signaling, and building pathways afterward. They are responsible for intestinal absorption and renal reabsorption of amino acids. In the CNS, orphan transporters constitute a significant medium for the provision of neurotransmitter precursors. Diseases related with aforementioned transporters highlight their significance; SLC6A19 mutations are associated with metabolic Hartnup disorder, whereas altered expression of SLC6A15 has been associated with a depression/stress-related disorders.Mutations of SLC6A18-SLCA20 cause iminoglycinuria and/or hyperglycinuria. SLC6A18-SLC6A20 to reach the cellular membrane require an ancillary unit ACE2 that is a molecular target for the spike protein of the SARS-CoV-2 virus. SLC6A19 has been proposed as a molecular target for the treatment of metabolic disorders resembling gastric surgery bypass. Inhibition of SLC6A15 appears to have a promising outcome in the treatment of psychiatric disorders. SLC6A19 and SLC6A20 have been suggested as potential targets in the treatment of COVID-19. In this review, we gathered recent advances on orphan transporters, their structure, functions, related disorders, and diseases, and in particular their relevance as therapeutic targets.

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“…In an HFD-induced mouse model of obesity, BCAA improved glucose tolerance, reduced hepatic steatosis, and attenuated adipose tissue inflammation [ 35 ]. Several studies suggest that BCAA may affect the hormonal regulators of satiety, resulting in decreased appetite after BCAA consumption [ 36 ]. In addition, BCAA can directly cross the blood–brain barrier via the same carrier systems as tryptophan—the precursor of serotonin [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice

et al. 2023

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Exercise and dietary interventions are promising approaches to tackle obesity and its obesogenic effects on the brain. We investigated the impact of exercise and possible synergistic effects of exercise and branched-chain amino acids (BCAA) supplementation on the brain and behavior in high-fat-diet (HFD)-induced obese Ldlr−/−.Leiden mice. Baseline measurements were performed in chow-fed Ldlr−/−.Leiden mice to assess metabolic risk factors, cognition, and brain structure using magnetic resonance imaging. Thereafter, a subgroup was sacrificed, serving as a healthy reference. The remaining mice were fed an HFD and divided into three groups: (i) no exercise, (ii) exercise, or (iii) exercise and dietary BCAA. Mice were followed for 6 months and aforementioned tests were repeated. We found that exercise alone changed cerebral blood flow, attenuated white matter loss, and reduced neuroinflammation compared to non-exercising HFD-fed mice. Contrarily, no favorable effects of exercise on the brain were found in combination with BCAA, and neuroinflammation was increased. However, cognition was slightly improved in exercising mice on BCAA. Moreover, BCAA and exercise increased the percentage of epididymal white adipose tissue and muscle weight, decreased body weight and fasting insulin levels, improved the circadian rhythm, and transiently improved grip strength. In conclusion, BCAA should be supplemented with caution, although beneficial effects on metabolism, behavior, and cognition were observed.

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Effect of branched-chain amino acids on food intake and indicators of hunger and satiety- a narrative summary

Cited by 8 publications

References 101 publications

Effect of camel milk and pistachio-based product on cancer-induced sarcopenia in Sprague Dawley rats

Effect of camel milk and pistachio-based product on cancer-induced sarcopenia in Sprague Dawley rats

The SLC6A15–SLC6A20 Neutral Amino Acid Transporter Subfamily: Functions, Diseases, and Their Therapeutic Relevance

The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice

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