Effect of brain extracts from rats subjected to metrazol kindling on generalized epileptic activity

Analgesic effects of spinal cord peptide factors produced during the establishment and development of generators of pathologically enhanced excitation in the rat spinal cord

“…Thus, when cerebellar nuclei pertaining to an Laboratory for General Pathology of the Nervous System and Laboratory for Pathophysiology or Pain, Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow antiepileptic system were activated, epileptic activity was suppressed or weakened, and substances capable of depressing epileptic activity in recipient animals were then detected in the brain and cerebrospinal fluid of donor animals [7]. Similar substances have been found to appear in animal and human cerebrospinal fluid after an epileptic seizure [3,7]. The present study was designed to determine which substances -pro-or antiepileptic -occur in the spinal cord when a pain syndrome (PS) of spinal origin is developing in rats under the influence of the GPEE formed in the dorsal horns of lumbosacral segments.…”

“…For example, pro-or antiepileptic substances of peptide nature were identified in the brain of tats during the intensification of convulsive activity in the event of kindling [3,6]. Presumably, the emergence of substances of a particular type reflects activation either of the pathological system underlying the disease process or of an antisystem that limits its development.…”