Effect of Brain Acetylcholine Depletion on Bicuculline-Induced Cardiovascular and Locomotor Responses

Tellioǧlu, Tahir; Aker, Rezzan; Oktay, S.; Onat, Filiz

doi:10.3109/00207459708988470

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…39 In animals, stimulating the amygdala increases SNS-related responding (blood pressure, heart rate). 102 Conversely, lesioning the amygdala, which renders the region ineffective, reduces stressor-evoked SNS-related responding. 103,104 Similarly, greater amygdala activity to acute stressors is associated with greater increases in blood pressure 105 and greater increases in IL-6, a key proinflammatory cytokine and measure of immune system activity, in humans.…”

Section: Giving Support and Healthmentioning

confidence: 99%

“…In addition to its role in parental inhibition, the amygdala is among other limbic forebrain structures that translate and process stressors to influence downstream physiological responding implicated in physical health . In animals, stimulating the amygdala increases SNS‐related responding (blood pressure, heart rate) . Conversely, lesioning the amygdala, which renders the region ineffective, reduces stressor‐evoked SNS‐related responding .…”

Section: Giving Support and Healthmentioning

confidence: 99%

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Neural mechanisms of the link between giving social support and health

Inagaki

2018

Annals of the New York Academy of Sciences

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Giving social support to others has emerged as an additional route by which social ties influence health. Thus, giving support to others not only influences the health of the individual receiving support, but also the health of the individual giving the support. However, the neural mechanisms by which giving support leads to health are only beginning to be explored. In hopes of consolidating and guiding future research on giving support and health, the current review considers why, how, and when giving support is health promoting. Special emphasis is placed on neural regions known to contribute to parental care in animals that both reinforce giving support behavior (ventral striatum and septal area) and reduce stress-related responding (e.g., amygdala) to facilitate care. Hypothesized links between neural regions involved in giving support and peripheral physiology (sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and related inflammatory responding) are considered as well as the conditions under which giving support should be most beneficial for health. Finally, the implications of the current perspective for understanding how social relationships, more broadly, contribute to health and suggestions for future directions are offered.

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Section: Giving Support and Healthmentioning

confidence: 99%

Section: Giving Support and Healthmentioning

confidence: 99%

Neural mechanisms of the link between giving social support and health

Inagaki

2018

Annals of the New York Academy of Sciences

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“…The central nucleus of the amgydala controls the expression of threat-related changes in autonomic (SNS) and endocrine responses (cortisol) through projections to the hypothalamus and brainstem areas (46). Stimulating the central nucleus of the amgydala increases blood pressure in rats (58), and greater amgydala activity during fear acquisition in humans is associated with greater SNS activity (skin conductance response; SCR) to a conditioned stimulus (51). Conversely, lesions to the central nucleus of the amygdala can reduce SNS and HPA responses to conditioned stimuli (59,60).…”

Section: Receiving or Perceiving Social Supportmentioning

confidence: 99%

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

Eisenberger

2013

Psychosomatic Medicine

161

114

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Decades of research have demonstrated strong links between social ties and health. Although considerable evidence has shown that social support can attenuate downstream physiological stress responses that are relevant to health, the neurocognitive mechanisms that translate perceptions of social ties into altered physiological responses are still not fully understood. This review integrates research from social and affective neuroscience to illuminate some of the neural mechanisms involved in social support processes, which may further our understanding of the ways in which social support influence health. This review focuses on two types of social support that have been shown to relate to health: receiving and giving social support. As the neural basis of receiving support, this article reviews the hypothesis that receiving support may benefit health through the activation of neural regions that respond to safety and inhibit threat-related neural and physiological responding. This article will then review neuroimaging studies in which subjects were primed with or received support during a negative experience as well as studies in which self-reports of perceived support were correlated with neural responses to a negative experience. As the neural basis of giving support, this article reviews the hypothesis that neural regions involved in maternal caregiving behavior may be critical for the health benefits of support-giving through the inhibition of threat-related neural and physiological responding. Neuroimaging studies in which subjects provided support to others or engaged in other related forms of prosocial behavior will then be reviewed. Implications of these findings for furthering our understanding of the relationships between social support and health are discussed.

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“…Furthermore, one of these regions, the SA, was negatively correlated with amygdala activity when participants gave support. The amygdala is a region well known for its association with threat detection and salience (Adolphs, Tranel, & Damasio, 1995;Anderson & Phelps, 2001;Whalen, 2007) and in animals, leads to increased cardiovascular responses (blood pressure, heart rate) when stimulated (Tellioglu, Aker, Oktay, & Onat, 1997). Similarly, amygdala activation to the Stroop color-word interference task has been linked to increased blood pressure (mean arterial pressure [MAP]) in humans (Gianaros et al, 2008).…”

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confidence: 99%

Giving support to others reduces sympathetic nervous system‐related responses to stress

Inagaki

Eisenberger

2015

Psychophysiology

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Social support is a major contributor to the link between social ties and beneficial health outcomes. Research to date has focused on how receiving support from others might be good for us; however, we know less about the health effects of giving support to others. Based on prior work in animals showing that stimulating neural circuitry important for caregiving behavior can reduce sympathetic-related responses to stressors, it is possible that, in humans, giving to others can reduce stressor-evoked sympathetic nervous system responding, which has implications for health outcomes. To test the effect of giving support on the physiological stress response, participants either wrote a supportive note to a friend (support-giving condition) or wrote about their route to school/work (control condition) before undergoing a standard laboratory-based stress task. Physiological responses (heart rate, blood pressure, salivary alpha-amylase, salivary cortisol), and self-reported stress were collected throughout the protocol. In line with hypotheses, support giving (vs. control) reduced sympathetic-related responses (systolic blood pressure and alphaamylase) to the stressor. No effects of support giving were found on self-reported psychological stress or cortisol levels. Results add to existing knowledge of the pathways by which support giving may lead to health benefits and highlight the contribution of giving to others in the broader social support-health link.

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Effect of Brain Acetylcholine Depletion on Bicuculline-Induced Cardiovascular and Locomotor Responses

Cited by 5 publications

References 23 publications

Neural mechanisms of the link between giving social support and health

Neural mechanisms of the link between giving social support and health

An Empirical Review of the Neural Underpinnings of Receiving and Giving Social Support

Giving support to others reduces sympathetic nervous system‐related responses to stress

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