1997
DOI: 10.3109/00207459708988470
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Effect of Brain Acetylcholine Depletion on Bicuculline-Induced Cardiovascular and Locomotor Responses

Abstract: Both GABAergic and cholinergic systems are involved in central cardiovascular regulation. Previous studies have shown that GABAA receptor antagonists cause increases in blood pressure, heart rate and locomotor activity. In this study, we examined the role of the depletion of brain acetylcholine on the cardiovascular responses and locomotor activity induced by bicuculline methiodide in conscious Sprague-Dawley rats. The doses of 0.3 and 0.5 nmol of intracerebroventricular bicuculline methiodide produced increas… Show more

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Cited by 5 publications
(6 citation statements)
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“…39 In animals, stimulating the amygdala increases SNS-related responding (blood pressure, heart rate). 102 Conversely, lesioning the amygdala, which renders the region ineffective, reduces stressor-evoked SNS-related responding. 103,104 Similarly, greater amygdala activity to acute stressors is associated with greater increases in blood pressure 105 and greater increases in IL-6, a key proinflammatory cytokine and measure of immune system activity, in humans.…”
Section: Giving Support and Healthmentioning
confidence: 99%
See 1 more Smart Citation
“…39 In animals, stimulating the amygdala increases SNS-related responding (blood pressure, heart rate). 102 Conversely, lesioning the amygdala, which renders the region ineffective, reduces stressor-evoked SNS-related responding. 103,104 Similarly, greater amygdala activity to acute stressors is associated with greater increases in blood pressure 105 and greater increases in IL-6, a key proinflammatory cytokine and measure of immune system activity, in humans.…”
Section: Giving Support and Healthmentioning
confidence: 99%
“…In addition to its role in parental inhibition, the amygdala is among other limbic forebrain structures that translate and process stressors to influence downstream physiological responding implicated in physical health . In animals, stimulating the amygdala increases SNS‐related responding (blood pressure, heart rate) . Conversely, lesioning the amygdala, which renders the region ineffective, reduces stressor‐evoked SNS‐related responding .…”
Section: Giving Support and Healthmentioning
confidence: 99%
“…The central nucleus of the amgydala controls the expression of threat-related changes in autonomic (SNS) and endocrine responses (cortisol) through projections to the hypothalamus and brainstem areas (46). Stimulating the central nucleus of the amgydala increases blood pressure in rats (58), and greater amgydala activity during fear acquisition in humans is associated with greater SNS activity (skin conductance response; SCR) to a conditioned stimulus (51). Conversely, lesions to the central nucleus of the amygdala can reduce SNS and HPA responses to conditioned stimuli (59,60).…”
Section: Receiving or Perceiving Social Supportmentioning
confidence: 99%
“…Furthermore, one of these regions, the SA, was negatively correlated with amygdala activity when participants gave support. The amygdala is a region well known for its association with threat detection and salience (Adolphs, Tranel, & Damasio, 1995;Anderson & Phelps, 2001;Whalen, 2007) and in animals, leads to increased cardiovascular responses (blood pressure, heart rate) when stimulated (Tellioglu, Aker, Oktay, & Onat, 1997). Similarly, amygdala activation to the Stroop color-word interference task has been linked to increased blood pressure (mean arterial pressure [MAP]) in humans (Gianaros et al, 2008).…”
mentioning
confidence: 99%