Effect of bowel obstruction on stage IV colorectal cancer

Chen, Wei; Tan, Xiaoping; Ye, Jun‐Wen; Q, Liu; Zeng, Qingli; Wang, Lei; Wang, Jianping

doi:10.3892/mco.2014.240

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…Other clinical factors, such as perforation and obstruction, were not studied because these factors were not available from the SEER database. However, these factors adversely impact outcomes and may affect the survival of CRC patients [ 35 , 36 ]. The SEER database includes only the US population, and the results of this study may not be transferred to all other countries.…”

Section: Discussionmentioning

confidence: 99%

Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

et al. 2021

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Background The identification of the homogeneous and heterogeneous risk factors for different types of metastases in colorectal cancer (CRC) may shed light on the aetiology and help individualize prophylactic treatment. The present study characterized the incidence differences and identified the homogeneous and heterogeneous risk factors associated with distant metastases in CRC. Methods CRC patients registered in the SEER database between 2010 and 2016 were included in this study. Logistic regression was used to analyse homogeneous and heterogeneous risk factors for the occurrence of different types of metastases. Nomograms were constructed to predict the risk for developing metastases, and the performance was quantitatively assessed using the receiver operating characteristics (ROC) curve and calibration curve. Results A total of 204,595 eligible CRC patients were included in our study, and 17.07% of them had distant metastases. The overall incidences of liver metastases, lung metastases, bone metastases, and brain metastases were 15.34%, 5.22%, 1.26%, and 0.29%, respectively. The incidence of distant metastases differed by age, gender, and the original CRC sites. Poorly differentiated grade, more lymphatic metastasis, higher carcinoembryonic antigen (CEA), and different metastatic organs were all positively associated with four patterns of metastases. In contrast, age, sex, race, insurance status, position, and T stage were heterogeneously associated with metastases. The calibration and ROC curves exhibited good performance for predicting distant metastases. Conclusions The incidence of distant metastases in CRC exhibited distinct differences, and the patients had homogeneous and heterogeneous associated risk factors. Although limited risk factors were included in the present study, the established nomogram showed good prediction performance.

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Section: Discussionmentioning

confidence: 99%

Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

et al. 2021

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“…The prognosis was even worse among patients who presented with intestinal obstruction and advanced-stage cancer. Several studies have demonstrated that the survival period for such patients ranges from a few weeks to several months [ 14 - 16 ]. For instance, Chen et al [ 16 ] studied the survival duration of patients with stage IV colorectal cancer complicated with bowel obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that the survival period for such patients ranges from a few weeks to several months [ 14 - 16 ]. For instance, Chen et al [ 16 ] studied the survival duration of patients with stage IV colorectal cancer complicated with bowel obstruction. Among 381 patients who had been diagnosed with stage IV disease, 295 patients had intestinal obstruction.…”

Section: Discussionmentioning

confidence: 99%

Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma?

Suan¹,

Tan²,

Soelar³

et al. 2015

Epidemiol Health

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OBJECTIVES:The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.METHODS:Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.RESULTS:Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).CONCLUSIONS:The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.

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“…There was significant heterogeneity (Cochran Q, P = 0.009; I 2 = 74.0%). When one study was omitted through sensitivity analysis [49], there was less significant heterogeneity (Cochran Q, P = 0.098; I 2 = 56.9%), with no noticeable influence on the pooled result.…”

Section: Obstructionmentioning

confidence: 97%

“…Four studies [22,[47][48][49], including data on 2799 patients (167 metachronous pmCRC, 2632 non-pmCRC) regarding malignant bowel obstruction, were included in the meta-analysis. The pooled analysis indicated that obstruction was positively associated with metachronous PM (OR 4.467; 95% CI 1.919-10.398; P = 0.001) (Figure 4a).…”

Section: Obstructionmentioning

confidence: 99%

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

et al. 2021

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Aim: Proactive detection and treatment strategies have achieved encouraging survival outcomes for patients with early peritoneal metastases (PM), but these costly and invasive approaches can only be applied to selected high-risk patients. This meta-analysis aimed to identify the risk factors for metachronous PM after curative surgery for colorectal cancer (CRC). Method:The study was registered at PROSPERO (CRD42020219187). Databases were searched for studies comparing clinical and histopathological characteristics between patients with metachronous peritoneal metastases from colorectal cancer (pmCRC) and patients without (non-pmCRC).Results:Thirtysix studies were included. Metachronous PM were positively associated

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Effect of bowel obstruction on stage IV colorectal cancer

Cited by 9 publications

References 26 publications

Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

Nomogram based on homogeneous and heterogeneous associated factors for predicting distant metastases in patients with colorectal cancer

Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma?

Risk factors for developing peritoneal metastases after curative surgery for colorectal cancer: A systematic review and meta‐analysis

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