Effect of Bowel Cleansing on Colonic Transit Time Measurement in Children with Chronic Constipation

Quitadamo, Paolo; Thapar, Nikhil; Staiano, Annamaria; Tambucci, Renato; Saliakellis, Efstratios; Pescarin, Matilde; Coluccio, Chiara; Lindley, Keith; Borrelli, Osvaldo

doi:10.1016/j.jpeds.2015.09.035

Cited by 13 publications

(14 citation statements)

References 12 publications

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“…They are satisfied with the condition of postoperative evacuation. It was pointed out that colonic transit study using radio-opaque marker showed slow colonic transit in patients with short types of severe Hypo and IND 9) . These patients show poor outcome after ARM.…”

Section: Results After Arm In Patients With the Other Causes Of Chronmentioning

confidence: 99%

“…In internal medicine, chronic constipation is defined by Rome III. On the other hand, in surgeon for surgical procedure, chronic constipation has been divided into groups with colonic inertia and with outlet obstruction by transit study, defecography, anorectal manometry, and electromyography 1,2,[5][6][7][8][9] . Defecography is useful for the diagnosis and evaluation of the morphological and functional abnormalities (especially outlet obstruction type of chronic constipation; anisumus, puborectalis syndrome) in the anorectal region.…”

Section: Introductionmentioning

confidence: 99%

“…Defecography is useful for the diagnosis and evaluation of the morphological and functional abnormalities (especially outlet obstruction type of chronic constipation; anisumus, puborectalis syndrome) in the anorectal region. On the other hand, transit study is very useful to detect slow transit type of chronic constipation type (colonic inertia) 9) . Anorectal myectomy (ARM) is appropriate for treatment in patients with outlet obstruction including ultrashort or short-type of Hirschsprung's disease (HD; aganglionosis), the allied disorders of HD such as hypoganglionosis (Hypo) and intestinal neuronal dysplasia (IND), and patients with high internal anal sphincter pressure [10][11][12][13][14][15][16] and encouraging results have been reported in children with short-type of HD and its allied disorders [17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

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Is Anorectal Myectomy useful for Hirschsprung’s Disease and its Allied Disorders?

Ryouichi

2017

Nichidai Igaku Zasshi

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The author reviewed the clinical features of children with Hirschsprung's disease (HD) and its allied disorders [hypoganglionosis (Hypo) and intestinal neuronal dysplasia (IND)] before and after anorectal myectomy (ARM). The incidence was greater in males than in females (1.5:1). The patients were between 0 and 15 years of age and more than half were less than 6 years old. Neurohistochemical examination showed Hypo [mild type (3/5 or more ganglion cells per ganglia compared with normal ganglia), severe type (less than 2/5 ganglion cells per ganglia compared with normal ganglia), IND, and HD (aganglionosis). Mild Hypo was the most common, compared with HD and NID. Abdominal pain was the most common symptom, followed by soiling and anal pain. Spontaneous evacuation without the need for laxatives was noted in 70~75% patients with a good outcome, and 30~40% of those with a satisfactory outcome after ARM. Patients with a poor outcome still required laxatives and other medical treatment. Related causes of constipation, i.e., colonic inertia, psychological or central nervous disorders, occurred at a higher incidence in those with a poor outcome. The most common related cause of constipation after ARM was colonic inertia, i.e., redundant colon. Additional operations (subtotal colectomy and ileorectal anastomosis) were performed for the patients with a poor outcome. These patients were satisfied with the postoperative state of evacuation. In conclusion, the abnormal distribution of ganglia, i.e. Hypo, IND, and HD could be largely related to the defecation disorders observed in childhood patients with chronic constipation. Patients with severe Hypo, IND, and HD, especially those with long affected colon, psychological or central nervous disorders, may experience significant persistent constipation after ARM. Additional operations should be performed in patients with a poor outcome due to colonic inertia.

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Section: Results After Arm In Patients With the Other Causes Of Chronmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is Anorectal Myectomy useful for Hirschsprung’s Disease and its Allied Disorders?

Ryouichi

2017

Nichidai Igaku Zasshi

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“…Slow transit constipation was defined on the basis of ≤2 defecation per week confirmed using radio‐opaque marker (ROM) study. The latter were performed according to a previously published protocol . Briefly, ROM test consisted of the child ingesting 3 capsules each containing a set of 10 distinctive ROMs in a specified order over 3 days.…”

Section: Methodsmentioning

confidence: 99%

“…The latter were performed according to a previously published protocol. 23 Briefly, ROM test consisted of the child ingesting 3 capsules each containing a set of 10 distinctive ROMs in a specified order over 3 days. Each child ingested individual capsules at 9 a.m. with breakfast on 3 consecutive days.…”

Section: Patientsmentioning

confidence: 99%