Effect of bovine serum albumin on the stability and antioxidant activity of blueberry anthocyanins during processing and in vitro simulated digestion

Zang, Zhihuan; Chou, Shurui; Si, Xu; Cui, Hong; Tan, Hui Yin; Ding, Yumeng; Liu, Ziyue; Wang, Haotian; Lang, Yuxi; Tang, Siyi; B, Li; Tian, Jinlong

doi:10.1016/j.foodchem.2021.131496

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…Syringic acid was detected and its presence is from the degradation of anthocyanins during colonic fermentation. Similar results were obtained by conjugating blueberry anthocyanins with bovine serum albumin [ 141 ].…”

Section: Absorption Digestion Metabolism and Bioavailability Of Pheno...supporting

confidence: 82%

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties

et al. 2022

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Nowadays, it is largely accepted that the daily intake of fruits, vegetables, herbal products and derivatives is an added value in promoting human health, given their capacity to counteract oxidative stress markers and suppress uncontrolled pro-inflammatory responses. Given that, natural-based products seem to be a promising strategy to attenuate, or even mitigate, the development of chronic diseases, such as diabetes, and to boost the immune system. Among fruits, cherries and blueberries are nutrient-dense fruits that have been a target of many studies and interest given their richness in phenolic compounds and notable biological potential. In fact, research has already demonstrated that these fruits can be considered functional foods, and hence, their use in functional beverages, whose popularity is increasing worldwide, is not surprising and seem to be a promising and useful strategy. Therefore, the present review reinforces the idea that cherries and blueberries can be incorporated into new pharmaceutical products, smart foods, functional beverages, and nutraceuticals and be effective in preventing and/or treating diseases mediated by inflammatory mediators, reactive species, and free radicals.

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Section: Absorption Digestion Metabolism and Bioavailability Of Pheno...supporting

confidence: 82%

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties

et al. 2022

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“…In our present study, Western blot, qRT-PCR and immunohistochemistry analysis show that cold stress-induced Nrf2, HO-1, NQO1, GCLC and GCLM distinctly increased. In addition, the body’s antioxidant capacity as a defense ability is closely related to health degree, and antioxidant substances play an important role in protecting the damage caused by stress [ 41 ]. Among them, enzymes exist widely in eukaryotes and play an irreplaceable role in defending various tissues and organs against oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway

et al. 2022

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The body needs to generate heat to ensure basic life activities when exposed to cold temperatures. The liver, as the largest glycogen storage organ in the body and main heat-producing organ at rest, may play a role in chronic cold exposure. Recent studies suggested that pyroptosis plays a crucial role in liver diseases. However, the role of pyroptosis in cold stress-induced liver injury is not clear. Hence, in this study, we attempted to investigate the effects of chronic cold exposure on liver function, apoptosis, oxidative stress and inflammation in mice by establishing a mouse model of chronic cold exposure, and to investigate whether pyroptosis pathways are involved in the process of chronic cold exposure. In vivo, our results show that inflammatory cell infiltration and other pathological changes in liver cells and the activity of liver enzyme evidently increased in the serum and liver of cold-exposed mice, suggesting cold stress may result in liver injury. Remarkably, increased expression of heat shock protein 70 (HSP70) and HSP90 proteins proved the cold stress model is successfully constructed. Then, elevated levels of apoptosis, inflammation, oxidative stress and pyroptosis related proteins and mRNAs, such as cysteinyl aspartate specific proteinase-3 (Caspase-3), inducible nitric oxide synthase (iNOS), nuclear factor erythroid2-related factor 2 (Nrf2) and gasdermins D (GSDMD), confirmed that cold exposure activated apoptosis, oxidative stress and pyroptosis, and released inflammation cytokines. Meanwhile, in vitro, we got similar results as in vivo. Further, adding an NLR family pyrin domain containing 3 (NLRP3) inhibitors found that suppression expression of NLRP3 results in the essential proteins of pyroptosis and antioxidant evidently reduced, and adding GSDMD inhibitor found that suppression expression of GSDMD accompanies with the level of Nrf2 and heme oxygenase-1 (HO-1) obviously reduced. In summary, these findings provide a new understanding of the underlying mechanisms of the cold stress response, which can inform the development of new strategies to combat the effects of hypothermia.

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“…The content changes of main monomer substances in microcapsules were quantitatively analyzed, as shown in Table 4 and Figure 4. During SOF, the main monomers decreased by 8.50%, 6.91%, 6.70%, 3.34%, 7.36%, 1.34% and 5.50%, respectively, phenolic acids were more stable than flavonoids in SOF (Zang et al, 2022). In SGF stage, the seven monomers' changes were 2.6%, 34.03%, 37.21%, 61.53%, 12.47%, 45.39% and 18.37%, respectively, and the two monomers with the highest content of rutin and chlorogenic acid were significantly decreased.…”

Section: Discussionmentioning

confidence: 90%

Structural characterization and stability of microencapsulated flavonoids from Lycium barbarum L. leaves

et al. 2023

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Effect of bovine serum albumin on the stability and antioxidant activity of blueberry anthocyanins during processing and in vitro simulated digestion

Cited by 22 publications

References 30 publications

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties

Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway

Structural characterization and stability of microencapsulated flavonoids from Lycium barbarum L. leaves

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