Effect of bovine seminal ribonuclease and bovine pancreatic ribonuclease A on bovine oocyte maturation

The Ribonuclease A superfamily includes an extensive network of distinct and divergent gene lineages. Although all ribonucleases of this superfamily share invariant structural and catalytic elements and some degree of enzymatic activity, the primary sequences have diverged significantly, ostensibly to promote novel function. We will review the literature on the evolution and biology of the RNase A ribonuclease lineages that have been characterized specifically as involved in host defense including: (1) RNases 2 and RNases 3, also known as the eosinophil ribonucleases, which are rapidly-evolving cationic proteins released from eosinophilic leukocytes, (2) RNase 7, an anti-pathogen ribonuclease identified in human skin, and (3) RNase 5, also known as angiogenin, another rapidly-evolving ribonuclease known to promote blood vessel growth with recently-discovered antibacterial activity. Interestingly, some of the characterized anti-pathogen activities do not depend on ribonuclease activity per se. We discuss the ways in which the anti-pathogen activities characterized in vitro might translate into experimental confirmation in vivo. We will also consider the possibility that other ribonucleases, such as the dimeric bovine seminal ribonuclease and the frog oocyte ribonucleases, may have host defense functions and therapeutic value that remain to be explored. (190 words).

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Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease

Matoušek

Souček

Slavík

et al. 2003

Comparative Biochemistry and Physiology Part C: Toxicology &

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Effect of bovine seminal ribonuclease and bovine pancreatic ribonuclease A on bovine oocyte maturation

Cited by 7 publications

References 35 publications

Bovine Seminal Ribonuclease and Its Special Features: When Two is Better Than One

Bovine Seminal Ribonuclease and Its Special Features: When Two is Better Than One

The RNase a superfamily: Generation of diversity and innate host defense

Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease

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