Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits

Tükel, Hüseyin Can; Dağlıoğlu, Yusuf Kenan; Tatlı, Ufuk; Gundogdu, Leman Sencar; Kürkçü, Mehmet; Benlidayı, Mehmet Emre

doi:10.1016/j.joms.2020.06.001

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…In a case series by Shilt et al, botulinum toxin was utilized in 5 male patients to achieve controlled immobilization and prevention of tendon repair failure following proximal hamstring avulsion repair [ 22 ]. In animal models, botulinum toxin has been used to improve fracture healing when injected into surrounding muscles in femoral and mandibular fractures [ 16 , 18 ]. Conversely, Hao et al demonstrated that botulinum toxin injections in the quadriceps muscles of rats with femur fractures resulted in muscle atrophy and instability that impaired callous maturation and union at 8 weeks postoperatively [ 30 ] ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Botulinum toxin injection has been previously described as a potential immobilization technique for fractures when injections are made into muscles that cross the fracture site or those that could produce excessive strain forces on the fracture if not adequately immobilized. Previous literature has shown favorable outcomes following botulinum toxin-induced immobilization in numerous fractures, including those of the clavicle, mandible, scapula, and femur [ 16 – 23 ]. To the best of our knowledge, this is the first report of botulinum toxin assisted immobilization of a distal humerus fracture in a PD patient with psychosis.…”

Section: Introductionmentioning

confidence: 99%

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Botulinum Toxin for Immobilization of a Surgically Managed Distal Humerus Fracture in Parkinson’s Disease-Associated Psychosis: A Case Report

et al. 2023

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Patient: Female, 75-year-old Final Diagnosis: Healing fracture Symptoms: Deformity • pain Clinical Procedure: Open reduction and internal fixation of the right humerus • revision of open reduction and internal fixation of the right humerus Specialty: Orthopedics and Traumatology Objective: Unusual clinical course Background: Attainment of extremity immobilization in orthopedic trauma patients experiencing psychosis is often uniquely challenging. Many fractures, including those of the distal humerus, require a period of immobilization postoperatively to optimize fracture healing. Patients with Parkinson’s disease have also been shown to have lower rates of union after fracture compared to the general population. The combination of Parkinson’s disease and associated psychosis requires heightened attention to those parameters that may hinder fracture healing, such as inadequate immobilization of the fracture. Botulinum toxin has previously been described as a potential adjunctive therapy for fracture immobilization but has not yet been described in the setting of distal humerus fractures. Case Report: A 75-year-old woman with Parkinson’s disease-associated psychosis presented 2 weeks after open reduction and internal fixation of a distal third humeral shaft fracture due to failure of fixation and episodes of violent hallucinations. The patient underwent irrigation and debridement, and revision open reduction and internal fixation. Given her uncontrolled hallucinations, intramuscular botulinum toxin injections were given to the right triceps, biceps, and brachialis muscles to aid in the immobilization of the right extremity and protect the surgical site during the perioperative period. The patient subsequently followed up at the clinic 3 months postoperatively with ongoing fracture healing, evidenced by bridging callous and bone formation on radiographs, as well as a return of motion to the extremity. Conclusions: Botulinum toxin may be a safe and effective adjunct for fracture immobilization in patients who are difficult to immobilize and have high fixation failure risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Botulinum Toxin for Immobilization of a Surgically Managed Distal Humerus Fracture in Parkinson’s Disease-Associated Psychosis: A Case Report

et al. 2023

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“…Compared to the no treatment group, those who received botulinum toxin A in their masseter muscle had significantly fewer plate fractures [ 12 ]. Similarly, an experimental study in rabbit mandibular fractures demonstrated significantly greater bone healing scores, bone volume-total volume values, and trabecular diameter values in the botulinum toxin A study group compared to a placebo group [ 13 ]. In another animal study, rat femur fractures experienced increased biomechanical and histopathologic healing when treated with botulinum toxin A compared to no treatment, though the fracture callus diameter was smaller [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Botulinum toxin as adjunct therapy in surgical management of a periprosthetic scapular spine fracture: a case report

White

Brusalis

Wellman

et al. 2022

Clin Shoulder Elbow

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Six months after undergoing reverse total shoulder arthroplasty (RSA) a 73-year-old woman sustained a periprosthetic scapular spine fracture following a fall. She was treated with open reduction and internal fixation (ORIF), followed by botulinum toxin injection into the deltoid muscle to temporarily minimize strain at the fracture. Fracture union was achieved by three months, with excellent clinical function more than one year following fracture fixation and full resolution of deltoid function. Scapular spine fracture following RSA can be treated with ORIF and temporary deltoid paralysis using botulinum toxin in the immediate postoperative period to safely support fracture healing.

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“…Zusammenfassend sollte bei bei einer ausbleibender Knochenheilung trotz suffizienter interner Fixierung, genügender Durchblutung und Ausschluss relevanter anderer Faktoren an die Kräfte der anliegenden Muskulatur als Auslöser von Mikrobewegungen gedacht werden. Alternativ könnte allenfalls durch die Ausschaltung der vermuteten Muskeln mit Botulinumtoxin 3 12 eine Tenotomie vermieden werden.…”

Section: Diskussionunclassified

Einheit ist Stärke – die unterschätzte Kraft der Sehnen bei einer Pseudarthrose

Fuest

Noser

Bignion

et al. 2022

Handchir Mikrochir Plast Chir

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FallberichtBei einem Sturz beim Fußballspielen zog sich der gesunde, damals 38 Jahre alte Patient eine skapholunäre (SL-) Bandläsion links zu. In Folge waren innerhalb von sieben Jahren insgesamt 13 operative Eingriffe nötig, bis eine vollständige Konsolidation der zuletzt angestrebten Skapho-Trapezio-Trapezoidal-(STT)-Arthrodese erreicht wurde. 5 Jahre nach der Verletzung auf der linken Seite kam es im Rahmen eines Distorsionstraumas rechts ebenfalls zu einer SL-Bandverletzung bei dem Patienten. Bei einem Stadium Geissler III wurde in einem auswärtigen Spital eine dynamische Stabilisierung mit einer ECRL-Sehnenplastik durchgeführt. Bei zunehmender SL-Dissoziation wurde aufgrund der Erfahrung mit der gleichen Problematik links schlussendlich eine Panarthrodese des rechten Handgelenkes vorgenommen.

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Effect of Botulinum Toxin Type A on Mandibular Fracture Healing: An Experimental Study in Rabbits

Cited by 6 publications

References 24 publications

Botulinum Toxin for Immobilization of a Surgically Managed Distal Humerus Fracture in Parkinson’s Disease-Associated Psychosis: A Case Report

Botulinum Toxin for Immobilization of a Surgically Managed Distal Humerus Fracture in Parkinson’s Disease-Associated Psychosis: A Case Report

Botulinum toxin as adjunct therapy in surgical management of a periprosthetic scapular spine fracture: a case report

Einheit ist Stärke – die unterschätzte Kraft der Sehnen bei einer Pseudarthrose

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