Effect of Bone Marrow Aspirate in Denervation-Induced Skeletal Muscle Atrophy

Lysak, A.S.; Savosko, Serhii I; Страфун, С.С.; Utko, N.; Makarenko, Olexandr

doi:10.36740/wlek202203112

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is still no clear understanding of how stem cell therapy can be implemented in clinical practice. There are experimental (Abbas et al., 2019; Farjah et al., 2018; Lysak et al., 2022; Strafun et al., 2020) and clinical studies (Hogendoorn et al., 2014) that show the benefits in muscle preservation after injection of concentrated autologous red bone marrow aspirate into denervated muscles. Concurrently, several scientists also describe a failure in attempts to manipulate resident muscle stem cells to facilitate muscle regeneration (Tavakoli et al., 2023).…”

Section: Regenerative Medicinementioning

confidence: 99%

Muscle preservation in proximal nerve injuries: a current update

Lysak,

Farnebo,

Geuna

et al. 2024

J Hand Surg Eur Vol

Self Cite

View full text Add to dashboard Cite

Optimal recovery of muscle function after proximal nerve injuries remains a complex and challenging problem. After a nerve injury, alterations in the affected muscles lead to atrophy, and later degeneration and replacement by fat-fibrous tissues. At present, several different strategies for the preservation of skeletal muscle have been reported, including various sets of physical exercises, muscle massage, physical methods (e.g. electrical stimulation, magnetic field and laser stimulation, low-intensity pulsed ultrasound), medicines (e.g. nutrients, natural and chemical agents, anti-inflammatory and antioxidants, hormones, enzymes and enzyme inhibitors), regenerative medicine (e.g. growth factors, stem cells and microbiota) and surgical procedures (e.g. supercharge end-to-side neurotization). The present review will focus on methods that aimed to minimize the damage to muscles after denervation based on our present knowledge.

show abstract

Section: Regenerative Medicinementioning

confidence: 99%

Muscle preservation in proximal nerve injuries: a current update

Lysak,

Farnebo,

Geuna

et al. 2024

J Hand Surg Eur Vol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although muscle size may not change, a promising sign is the emergence of new fibers, especially within 6 months [63]. Unfortunately, long-term reinnervation after severe nerve injury often lacks regenerative effects substantial enough to compensate for muscle atrophy [64]. There are still no standardized neuromuscular rehabilitation protocols available to rescue muscles or restore their size in SCI patients, particularly those with motor neuron denervation of the lower limbs [65].…”

Section: Pathophysiology Of Spinal Cord Injuriesmentioning

confidence: 99%

Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries

Lana,

Navani,

Jeyaraman

et al. 2024

Bioengineering

View full text Add to dashboard Cite

Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading to significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, and surgical interventions, often fall short in fully addressing the underlying pathophysiology and resultant disabilities. Emerging research in the field of regenerative medicine has introduced innovative approaches such as autologous orthobiologic therapies, with bone marrow aspirate (BMA) being particularly notable for its regenerative and anti-inflammatory properties. This review focuses on the potential of BMA to modulate inflammatory pathways, enhance tissue regeneration, and restore neurological function disrupted by SCI. We hypothesize that BMA’s bioactive components may stimulate reparative processes at the cellular level, particularly when applied at strategic sites like the sacral hiatus to influence lumbar centers and higher neurological structures. By exploring the mechanisms through which BMA influences spinal repair, this review aims to establish a foundation for its application in clinical settings, potentially offering a transformative approach to SCI management that extends beyond symptomatic relief to promoting functional recovery.

show abstract

Retrospective analysis of hand and foot function after application of cellular technologies in patients with post–traumatic ischemic and denervation–reinervation injuries of limb muscles

Polyachenko,

Kostrub,

Dolgopolov

et al. 2024

UJCS

View full text Add to dashboard Cite

Objective. To determine the effect of cell therapy on the function of the hand and foot in patients with ischemic and denervation–reinervation injuries of the limb muscles. Materials and methods. Over 9 years (2014 – early 2023), 47 patients with posttraumatic ischaemia and/or peripheral nerve damage were treated at the Institute of Traumatology and Orthopedics. Cell therapy, namely the injection of bone marrow aspirate and adipose tissue suspension (cell substrates) into the target muscles, was used in 32 (68.1%) patients (main group), while 15 (31.9%) patients did not undergo cell therapy (control group). In 16 (50%) patients, cell therapy was applied to the upper limb, and in 16 (50%) – to the lower limb. Patients in the control and intervention groups were divided into three subgroups: with ischaemic contracture, peripheral nerve damage, and a combination of these pathologies. Results. The treatment with the use of cellular technology in patients with ischaemic and denervation–reinervation injuries of the muscles of the hand and foot had a statistically significant positive effect. In patients with ischaemic contracture of the hand 12 months after the introduction of cell substrates, the loss of its function decreased to less than 30%. Conclusions. Cell therapy helps to restore hand and foot function in patients with ischemic and/or denervation–reinervation injury of the limb muscles.

show abstract

Effect of Bone Marrow Aspirate in Denervation-Induced Skeletal Muscle Atrophy

Cited by 4 publications

References 15 publications

Muscle preservation in proximal nerve injuries: a current update

Muscle preservation in proximal nerve injuries: a current update

Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries

Retrospective analysis of hand and foot function after application of cellular technologies in patients with post–traumatic ischemic and denervation–reinervation injuries of limb muscles

Contact Info

Product

Resources

About