Effect of Body Weight on Sperm Concentration in Normozoospermic Males

Koloszár, S; Fejes, Imola; Závaczki, Zoltán; J, Daru; Szöllősi, János; A, Pal

doi:10.1080/01485010590919701

Cited by 76 publications

(45 citation statements)

References 10 publications

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“…This results in agreement with previous studies [9][10][11][12][13][14].A possible association between metabolic syndrome (MS) and male infertility has been hypothesized. Male obesity and (MS) are associated with hypogonadism [27].…”

Section: Discussionsupporting

confidence: 83%

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Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

2017

ijs

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The objective of the present study was to investigate the effect of body mass index (BMI) on semen parameters, level of sex hormone and sperm DNA integrity. Semen samples were collected from (85) infertile men and (40) healthy fertile men with range of age (38.191 ± 0.84) years during their attendance at High Institute of Infertility Diagnosis and ART, Al-Nahrain University from March to June 2016. Semen samples were obtained by masturbation after 72 hours of abstinence. Seminal fluid analyses included semen volume, sperm concentration, percent sperm motility, percent sperm morphology, and sperm chromatin integrity DNA fragmentation index (DFI]). Serum samples were collected from each subject for determination the level of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL), and Testosterone by ELISA method. The results revealed a highly significant (P≤ 0.01) increase in BMI and immotile sperm (%), and significant(P≤ 0.05) increase in semen liquefaction time, nonprogressive motility (%), round cells counts and sperm DNA fragmentation in infertile men as compared to control group, while there was a highly significant (P≤ 0.01) decrease in progressive motility (%), and a significant (P< 0.05) decrease in the sperm concentration, sperm motility (%) and normal sperm morphology (%). The results showed statistically significant (P< 0.05) positive correlations between body mass index and sperm motility, progressive motility, non-progressive motility, immotile sperm, normal sperm morphology and sperm DNA fragmentation. No significant correlations were observed between body mass index and semen liquefaction time, semen PH, sperm concentration, round cells counts and age. In respect with level of serum hormones a significant (P< 0.05) decrease in level of FSH ,LH and testosterone was found ,while the level of prolactin showed a significant (P< 0.05) increase in infertile men when compared with control group. Significant (P< 0.05) negative correlation was observed between body mass index and serum level of prolactin and testosterone, while nonsignificant correlations were observed between body mass index and serum level of FSH and LH. In conclusion, this study has shown that body mass index has major effect on semen characteristics and sex hormones. Science, 2017, Vol. 58, No.3B, pp: 1428-1236 ‫الجنسية.‬ ‫اليورمونات‬ ‫و‬ ‫النطف‬ ‫معايير‬ ‫عمى‬ ‫كبير‬ IntroductionObesity is a medical condition in which excess body fat, or white adipose tissue, accumulates in the body to the extent that the excess fat adversely affects health, the fundamental cause of obesity and overweight is an energy imbalance, where the energy consumed exceeds the energy expended. Global increases in overweight and obesity are attributable to a number of factors, including a shift in diet toward increased intake of energy-dense foods that are high in fat and sugars, and a trend toward decreased physical activity [1]. Body mass index (BMI) defined as the weight in kilograms divided by the square of the height in meters...

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Section: Discussionsupporting

confidence: 83%

“…Total body fat, intra-abdominal fat, and subcutaneous fat have all been associated with low levels of total and free testosterone [8]. Body mass index has been associated with alterations in sperm parameters in several reports [9][10][11]. Many studies have…”

Section: Introductionmentioning

confidence: 99%

Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

2017

ijs

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“…There is a negative impact of male obesity on standard semen parameters, including motility, count, and hormone abundance, such as testosterone and inhibin B (1,5,16,18,21,22,32,35,37,45,47,52,62,69,85). Further studies have reported reduced pregnancy success and live birth outcomes after IVF treatment in overweight and obese men (9, 42).…”

mentioning

confidence: 99%

“…Consequently, the rates of male obesity in reproductive age men has nearly tripled since the 1970s (33). Recent studies in both humans and other species shows that male obesity impairs male reproductive potential, affecting both the molecular and physical structure of sperm (1,10,16,20,21,34,35,38,45,47,50,63,75,79) and the health of the developing fetus and subsequent offspring (9,24,42,55,59). …”

mentioning

confidence: 99%

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

Palmer¹,

Bakos

Owens³

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

194

181

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Palmer NO, Bakos HW, Owens JA, Setchell BP, Lane M. Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. Am J Physiol Endocrinol Metab 302: E768 -E780, 2012. First published January 17, 2012; doi:10.1152/ajpendo.00401.2011.-Male obesity is associated with reduced sperm motility and morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied. Therefore, the aim of this study was to assess the reversibility of obesity and its associated sperm physiology and function in mice in response to weight loss through diet and exercise. C57BL6 male mice (n ϭ 40) were fed either a control diet (CD; 6% fat) or a high-fat diet (HFD; 21% fat) for 10 wk before allocation to either diet and/or swimming exercise interventions for 8 wk. Diet alone reduced adiposity (1.6-fold) and serum cholesterol levels (1.7-fold, P Ͻ 0.05), while exercise alone did not alter these, but exercise plus diet also improved glucose tolerance (1.3-fold, P Ͻ 0.05). Diet and/or exercise improved sperm motility (1.2-fold) and morphology (1.1-fold, P Ͻ 0.05), and reduced sperm DNA damage (1.5-fold), reactive oxygen species (1.1-fold), and mitochondrial membrane potential (1.2-fold, P Ͻ 0.05) and increased sperm binding (1.4-fold) (P Ͻ 0.05). Sperm parameters were highly correlated with measures of glycemia, insulin action, and serum cholesterol (all P Ͻ 0.05) regardless of adiposity or intervention, suggesting a link between systemic metabolic status and sperm function. This is the first study to show that the abnormal sperm physiology resulting from obesity can be reversed through diet and exercise, even in the presence of ongoing obesity, suggesting that diet and lifestyle interventions could be a combined approach to target subfertility in overweight and obese men. lifestyle interventions; fertility and metabolism OBESITY IS A GLOBAL HEALTH PROBLEM that is reaching epidemic proportions, with 1.6 billion adults classified as overweight and 400 million adults classified as obese worldwide (60). Consequently, the rates of male obesity in reproductive age men has nearly tripled since the 1970s (33). Recent studies in both humans and other species shows that male obesity impairs male reproductive potential, affecting both the molecular and physical structure of sperm (1,10,16,20,21,34,35,38,45,47,50,63,75,79) and the health of the developing fetus and subsequent offspring (9,24,42,55,59).Although fertility is not always impaired in obese men, almost 80% of men that present to fertility clinics are classified as either overweight or obese, suggestive of an interaction between obesity and sperm function (9). There is a negative impact of male obesity on standard semen parameters, including motility, count, and hormone abundance, such as testosterone and inhibin B (1,5,16,18,21,22,32,35,37,45,47,52,62,69,85). Further studies have reported reduced pregnancy success and live birth outcomes after IVF treatment in overweight and...

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“…In a follow up study in couples enrolled in the agricultural health study in USA [23] found a dose-response relationship between infertility and male BMI and that association was similar for older or younger men. Other authors have found that semen parameters are affected in men BMI above or below normal levels [24][25][26][27][28][29] . Maternal BMI may also have effect on the semen quality in sons of overweight mothers.…”

Section: Obesitymentioning

confidence: 99%

Role of Life Style Factors with Respect to Semen Quality and ART

Maggavi¹

2017

JMSCR

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Effect of Body Weight on Sperm Concentration in Normozoospermic Males

Cited by 76 publications

References 10 publications

Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

Role of Life Style Factors with Respect to Semen Quality and ART

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