Effect of Body Weight on Testosterone/Estradiol Ratio in Oligozoospermic Patients

Fejes, Imola; Koloszár, S; Závaczki, Zoltán; J, Daru; Szöllősi, János; Pál, A.

doi:10.1080/01485010500315479

Cited by 124 publications

(87 citation statements)

References 18 publications

(19 reference statements)

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“…Aromatase is expressed in the intercellular septa of fat tissue and converts testosterone to 17β-estradiol. 10 Obesity is one of the causes of secondary hypogonadism (Box 1). In obese men, increased adipose tissue results in increased aromatase activity and a relative elevation in estradiol levels, which inhibits gonadotropin secretion from the pituitary.…”

Section: Discussion Of Diagnosismentioning

confidence: 99%

Treatment of male infertility secondary to morbid obesity

2008

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SUMMARYBackground-A 29-year-old man presented to a clinic with infertility and hypogonadism in the setting of morbid obesity. On presentation, he had notable gynecomastia and a low testicular volume. The patient's weight was 154 kg and his height was 168 cm (BMI 54.5 kg/m 2 ). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels.

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Section: Discussion Of Diagnosismentioning

confidence: 99%

Treatment of male infertility secondary to morbid obesity

2008

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“…It has been shown that the elevated BMI of men results in decreased fecundity (Sallmen et al, 2006;Ramlau-Hansen et al, 2007). To interpret the reduced fertility of obese men, studies have investigated the relationship between obesity and semen quality (Fejes et al, 2005;Levitas et al, 2007;Hammoud et al, 2008;Pauli et al, 2008;Martini et al, 2010;McDonald et al, 2010). The results are conflicting.…”

Section: Introductionmentioning

confidence: 87%

The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome

et al. 2012

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It has been reported that increased body mass index (BMI) of men influences fecundity but it is not clear if it impacts on sperm parameters. Whether or not BMI of men influence sperm parameters and subsequently in vitro fertilization (IVF) result remains to be clarified. The aim of the present study was primarily to investigate the relationship between the BMI of men and sperm parameters (volume, concentration and motility) and whether or not it impacts on embryo quality and IVF outcome. Secondly, to investigate the impact of BMI of both men and women, in combination with their age, on IVF result. Three hundred and one couples were categorized according to their BMI. Group 1 (n = 64, both men and women had BMI l 25 kg/m 2 ), group 2 (n = 79, both men and . Overall (n = 301) BMI and age of men did not correlate with sperm parameters. Group 1 and group 4, regardless of the BMI of their women, demonstrated the highest quality of embryos and consequently the highest percentage of pregnancy. Furthermore, the score of the combination of both BMI and age of both men and women resulted in a threshold level of less than 800 with a relative high per cent of pregnancy. BMI of men does not correlate with sperm parameters, but influences the quality of produced embryos in such a way that impacts on pregnancy rate.

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“…When it comes to endocrine factors, the following are linked to components of the metabolic syndrome: hyperinsulinaemia, 13 an increased level of oestradiol, 30 a reduced level of testosterone, 31,32 a reduced testosterone/oestradiol quotient 33 and a reduced level of SHBG. 34 All these endocrine aberrations, with the exception of a reduced testosterone level, which did not reach statistical significance, were linked to BPH as measured by the total prostate gland volume in the present report.…”

Section: Discussionmentioning

confidence: 99%

Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia

Hammarsten

Damber

Karlsson

et al. 2008

Prostate Cancer Prostatic Dis

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The aetiology of benign prostatic hyperplasia (BPH) remains unclear. The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH. The design was a risk factor analysis of BPH in which the total prostate gland volume was related to endocrine and anthropometric factors. The participants studied were 184 representative men, aged 72-76 years, residing in Gö teborg, Sweden. Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (b ¼ 0.200, P ¼ 0.028), free oestradiol (b ¼ 0.233, P ¼ 0.008) and lean body mass (b ¼ 0.257, P ¼ 0.034). Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses. Our findings also seem to confirm the metabolic syndrome hypothesis. The metabolic syndrome and its major endocrine aberration, hyperinsulinaemia, are possible primary events in BPH.

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Effect of Body Weight on Testosterone/Estradiol Ratio in Oligozoospermic Patients

Cited by 124 publications

References 18 publications

Treatment of male infertility secondary to morbid obesity

Treatment of male infertility secondary to morbid obesity

The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome

Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia

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